Inflammatory processes affecting the pancreas present clinically as two distinct entities: acute and chronic pancreatitis. Although both exhibit characteristic morphological features, there is a certain overlap, in particular in the pathology of a common complication of both diseases, the pancreatic pseudocyst. In recent years, new types of chronic pancreatitis have been characterized, and attempts are made at using a more etiology-based terminology, such as hereditary chronic pancreatitis, obstructive chronic pancreatitis, and autoimmune pancreatitis. Diagnostic algorithms, consensus guidelines, and practical guidance on the assessment of IgG4 immunohistochemistry are included in the discussion of autoimmune pancreatitis and its differential diagnoses. In addition to the prototypical acute and chronic pancreatitis, other inflammatory processes which may affect the pancreas, either primarily or, more often, as part of a multiorgan or systemic disease (e.g., collagen vascular disease or sarcoidosis), are also included in this chapter.
KeywordsAcute Pancreatitis Chronic Pancreatitis Pancreatic Duct Severe Acute Pancreatitis Autoimmune Pancreatitis
- 1.Andrén-Sandberg Å. Chap 7: Classification of pancreatitis. In: Löhr M, Andrén-Sandberg Å, editors. Pancreatitis – diagnosis and therapy. Bremen/London/Boston: Uni-Med Verlag AG; 2011. p. 73–81.Google Scholar
- 2.Sharma S, Green KB. The pancreatic duct and its arteriovenous relationship. An underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens. Am J Surg Pathol. 2004;28:613–20.PubMedCrossRefGoogle Scholar
- 14.Mizukami H, Yajima N, Wada R, Matsumoto K, Kojima M, Klöppel G, et al. Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis. Virchows Arch. 2006;448:552–60.PubMedCrossRefGoogle Scholar
- 22.Lewin DNB. Systemic illnesses involving the GI tract. In: Odze RD, Goldblum JR, Crawford JM, editors. Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders; 2004. p. 73–6, chapter 5.Google Scholar