Abstract
This group of pancreatic neoplasms is characterized by a predominant neuroendocrine differentiation. Over the years, the terminology and classification of endocrine neoplasia arising in the pancreas has undergone multiple changes. The most recent alterations were introduced in 2010 by the WHO classification of tumors of the digestive system, 6 years after the WHO classification of tumors of endocrine organs had been published. The rationale for the change in classification and the defining criteria of the various categories are discussed in this chapter. A detailed description of the wide range of microscopic appearances that can be exhibited by pancreatic neuroendocrine neoplasia is provided, and the differential diagnostic considerations thereof are discussed. Separate chapter sections are dedicated to the application of the current staging systems and the indications for the use of immunohistochemistry. Information regarding clinical aspects of functioning and nonfunctioning endocrine tumors, together with the genetic syndromes that include pancreatic neuroendocrine tumors, is also provided.
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Campbell, F., Verbeke, C.S. (2013). Endocrine Neoplasia. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_20
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DOI: https://doi.org/10.1007/978-1-4471-2449-8_20
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