Abstract
Most of the mesenchymal neoplasms that occur primarily in soft tissues can arise in the pancreas, but they are extremely rare. The pancreas is much more commonly involved by extrapancreatic mesenchymal neoplasia secondarily involving the pancreas, either by direct invasion or, very occasionally, as a metastasis. It is not always possible to clearly determine the primary origin of a neoplasm on imaging techniques and, therefore, extrapancreatic tumors may be mistaken for primary pancreatic neoplasms on radiology. The morphological features, immunohistochemical profile, and cytogenetics of those mesenchymal tumors that may mimic other pancreatic neoplasms are discussed. Non-Hodgkin lymphomas may also occur in the pancreas although secondary involvement is much more common than primary pancreatic lymphoma. Primary lymphoma is briefly discussed in this chapter.
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References
Bismar TA, Basturk O, Gerald WL, Schwarz K, Adsay NV. Desmoplastic small cell tumor in the pancreas. Am J Surg Pathol. 2004;28:808–12.
Kosmahl M, Pauser U, Peters K, Sipos B, Luttges J, Kremer B, et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch. 2004;445:168–78.
Pauser U, da Silva MT, Placke J, Klimstra DS, Klöppel G. Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Mod Pathol. 2005;18:1211–6.
Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, et al. Granular cell tumor of the pancreas: a case report and review of literature. World J Gastrointest Oncol. 2010;2:121–4.
Yamamoto H, Yamaguchi H, Aishima S, Oda Y, Kohashi K, Oshiro Y, et al. Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. Am J Surg Pathol. 2009;33:1330–40.
Zhang H, Jensen MH, Farnell MB, Smyrk TC, Zhang L. Primary leiomyosarcoma of the pancreas: study of 9 cases and review of literature. Am J Surg Pathol. 2010;34:1849–56.
Lee JY, Seo HI, Park EY, et al. Histologic confirmation of huge pancreatic lipoma: a case report and review of literatures. J Korean Surg Soc. 2011;81:427–30.
Singhi AD, Hruban RH, Fabre M, Imura J, Schulick R, Wolfgang C, et al. Peripancreatic paraganglioma: a potential diagnostic challenge in cytopathology and surgical pathology. Am J Surg Pathol. 2011;35:1498–504.
Movahedi-Lankarani S, Hruban RH, Westra WH, Klimstra DS. Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 2002;26:1040–7.
Doi H, Ichikawa S, Hiraoka A, Ichiryu M, Nakahara H, Ochi H, et al. Primitive neuroectodermal tumor of the pancreas. Intern Med. 2009;48:329–33.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG. Primary pancreatic cystic neoplasms of the pancreas revisited. Part IV: rare cystic neoplasms. Surg Oncol. 2012;21:153–63.
Further Reading
Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas, Atlas of tumor pathology, 4th series, Fascicle 6. Washington, D.C.: Armed Forces Institute of Pathology; 2007. p. 305–24, chapter 13.
Jaffe ES, Muller-Hermelink HK, Delabie J, Ko YH, Nakamura S. Lymphoma of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system, World Health Organization Classification of tumours. Lyon: IARC; 2010. p. 332, chapter 12.
Miettinen M, Fletcher CDM, Kindblom LG, Tsui WMS. Mesenchymal tumours of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system, World Health Organization Classification of tumours. Lyon: IARC; 2010. p. 331, chapter 12.
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Campbell, F., Verbeke, C.S. (2013). Non-epithelial Neoplasia. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_11
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DOI: https://doi.org/10.1007/978-1-4471-2449-8_11
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