Abstract
Morphologic diagnosis of skin lesions is traditionally performed with punch biopsies or incisional biopsies. Skin nodules are excised for both curative and diagnostic purposes. Fine-needle aspiration cytology (FNA) offers the possibility of avoiding surgical biopsy and provides rapid diagnosis.
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References
Layfield LJ, Glasgow BJ. Aspiration biopsy cytology of primary cutaneous tumors. Acta Cytol. 1993;37:679–88.
Bansal R, Patel T, Sarin J, et al. Cutaneous and subcutaneous metastases from internal malignancies: an analysis of cases diagnosed by fine needle aspiration. Diagn Cytopathol. 2011;39:882–7.
Daskalopoulou D, Galanopoulou A, Statiropoulou P, et al. Cytologically interesting cases of primary skin tumors and tumor-like conditions identified by fine-needle aspiration biopsy. Diagn Cytopathol. 1998;19:17–28.
Daskalopoulou D, Maounis N, Kokalis G, et al. The role of fine needle aspiration cytology in the diagnosis of primary skin tumors. Arch Anat Cytol Pathol. 1993;41:75–81.
Bardales RH, Baker SJ, Mukunyadzi P. Fine-needle aspiration cytology findings in 214 cases of nonparotid lesions of the head. Diagn Cytopathol. 2000;22:211–7.
Spitz DJ, Reddy V, Selvaggi SM, et al. Fine-needle aspiration of scalp lesions. Diagn Cytopathol. 2000;23:35–8.
Bansal R, Naik R. A study of 70 cases of cutaneous metastases from internal carcinoma. J Indian Med Assoc. 1998;96:10–2.
Baloch ZW, Sack MJ, Yu GH, Gupta PK. Papillary formations in metastatic melanoma. Diagn Cytopathol. 1999;20:148–51.
Bhanot UK, Rauniyar SK, Mital VP. Fine needle aspiration cytology of metastatic skin nodules. A report of 2 cases. Acta Cytol. 2007;51:95–8.
Pánczél G, Liszkay G, Borbola K, et al. The importance of fine needle aspiration cytology in the management of recurrent and metastatic melanoma. Orv Hetil. 2012;153:1419–23.
Hosseinzadeh M, Omidifar N, Lohrasb MH. Use of fine needle aspiration cytology in the diagnosis of cutaneous leishmaniasis: a comparison with the conventional scraping method. Trop Doct. 2012;42:112–3.
Kar S, Krishnan A, Gangane N, Preetha K. Scrofuloderma—a case series from rural India. Indian J Tuberc. 2011;58:189–95.
Arghya B, Kaushik M, Mimi G, Subrata C. Cytodiagnosis of cutaneous histoplasmosis in HIV positive patient initially presenting with multiple umbilicated disseminated skin nodules. Diagn Cytopathol. 2013;41(5):459–62. doi:10.1002/dc.21814.
Mehdi G, Maheshwari V, Ansari HA, et al. Modified fine-needle aspiration technique for diagnosis of granulomatous skin lesions with special reference to leprosy and cutaneous tuberculosis. Diagn Cytopathol. 2010;38:391–6.
Eddyani M, Fraga AG, Schmitt F, et al. Fine-needle aspiration, an efficient sampling technique for bacteriological diagnosis of nonulcerative Buruli ulcer. J Clin Microbiol. 2009;47:1700–4.
Amita K, Shankar SV, Hazarika A, Roopa A. Fine needle aspiration cytology of unilesional mycosis fungoides d’emblee. J Cytol. 2012;29:54–6.
Wadhwa N, Batra M, Singh B. Nonhealing ulcer—a rare initial presentation of chronic myeloid leukemia diagnosed on aspiration cytology. Diagn Cytopathol. 2011;39:135–7.
Balachandran I, Walker Jr JW, Broman J. Fine needle aspiration cytology of ALK1(−), CD30+ anaplastic large cell lymphoma post renal transplantation: a case report and literature review. Diagn Cytopathol. 2010;38:213–6.
Zhao J, Han B, Shen T, et al. Primary cutaneous diffuse large B-cell lymphoma (leg type) after renal allograft: case report and review of the literature. Int J Hematol. 2009;89:113–7.
Song K, Das K. Cutaneous sarcoidosis in a woman with chronic hepatitis C and interferon therapy: a case report. Acta Cytol. 2010;54:863–6.
Raddaoui E, Ameeri S. Abdominal wall endometriosis: a report of 2 cases with primary diagnosis by fine needle aspiration. Acta Cytol. 2010;54:214–6.
Bhambhani S, Das DK, Luthra UK. Fine needle aspiration cytology in the diagnosis of sinuses and ulcers of the body surface (skin and tongue). Acta Cytol. 1991;35:320–4.
García-Rojo B, García-Solano J, Sánchez-Sánchez C, et al. On the utility of fine-needle aspiration in the diagnosis of primary scalp lesions. Diagn Cytopathol. 2001;24:104–11.
Gupta RK, Naran S. Fine needle aspiration cytology of cutaneous and subcutaneous metastatic deposits from epithelial malignancies. An analysis of 146 cases. Acta Cytol. 1999;43:126–30.
Shin HJ, Sneige N, Staerkel GA. Utility of punch biopsy for lesions that are hard to aspirate by conventional fine-needle aspiration. Cancer. 1999;87:149–54.
Fang X, Ma B. Fine needle aspiration cytology of basal cell carcinoma of the skin: a clinical and cytopathological appraisal. J Dermatol. 1999;26:640–6.
Dey P, Das A, Radhika S, Nijhawan R. Cytology of primary skin tumors. Acta Cytol. 1996;40:708–13.
Agrawal P, Banik T, Dey P. Calcinosis cutis: diagnosis by fine needle aspiration cytology–a rare case report. Diagn Cytopathol. 2011;39:917–8.
Solans EP, Bakhos R, Castelli MJ, Gattuso P. Fine needle aspiration biopsy of calcinosis cutis. A case report. Acta Cytol. 1997;41:590–2.
Halloush RA, Lavrovskaya E, Mody DR, et al. Diagnosis and typing of systemic amyloidosis: the role of abdominal fat pad fine needle aspiration biopsy. Cytojournal. 2010;6:24.
Shidham VB, Hunt B, Jardeh SS, et al. Performing and processing FNA of anterior fat pad for amyloid. J Vis Exp. 2010;(44):1747. doi:10.3791/1747.
Bhavsar T, Vincent G, Durra H, et al. Primary amyloidosis involving mesenteric lymph nodes: diagnosis by fine-needle aspiration cytology. Acta Cytol. 2011;55:296–301.
Kim JY, Kwon JE, Kim HJ, Park K. Fine-needle aspiration cytology of abdominal wall endometriosis: a study of 10 cases. Diagn Cytopathol. 2013;41(2):115–9. doi:10.1002/dc.21779.
Pathan SK, Kapila K, Haji BE, et al. Cytomorphological spectrum in scar endometriosis: a study of eight cases. Cytopathology. 2005;16:94–9.
Tabbara SO, Covell JL, Abbitt PL. Diagnosis of endometriosis by fine-needle aspiration cytology. Diagn Cytopathol. 1991;7:606–10.
Kim HS, Joo M, Chang SH. FNA cytology of subcutaneous panniculitis-like T-cell lymphoma with granulomas: a diagnostic pitfall. Cytopathology. 2011;22:63–4.
Cobb CJ, Greaves TS, Raza AS. Fine needle aspiration cytology and diagnostic pitfalls in Warthin’s tumor with necrotizing granulomatous inflammation and facial nerve paralysis: a case report. Acta Cytol. 2009;53:431–4.
Bruijnesteijn Van Coppenraet ES, Lindeboom JA, Prins JM, et al. Real-time PCR assay using fine-needle aspirates and tissue biopsy specimens for rapid diagnosis of mycobacterial lymphadenitis in children. J Clin Microbiol. 2004;42:2644–50.
Chantranuwat C. Polymerase chain reaction for detection of Mycobacterium tuberculosis in papanicolaou-stained fine needle aspirated smears for diagnosis of cervical tuberculous lymphadenitis. Southeast Asian J Trop Med Public Health. 2006;37:940–7.
Marks RA, Cramer HM, Wu HH. Fine-needle aspiration cytology of basaloid squamous cell carcinoma and small cell carcinoma—a comparison study. Diagn Cytopathol. 2013;41:81–4.
Christensen E, Bofin A, Gudmundsdóttir I, Skogvoll E. Cytological diagnosis of basal cell carcinoma and actinic keratosis, using Papanicolaou and May-Grünwald-Giemsa stained cutaneous tissue smear. Cytopathology. 2008;19:316–22.
Berner A, Soler A, Warloe T. Skin scrape cytology in the diagnosis of nodular basal cell carcinoma for treatment by photodynamic therapy. Acta Derm Venereol. 1999;79:147–9.
Kassi M, Kasi PM, Afghan AK, et al. The role of fine-needle aspiration cytology in the diagnosis of Basal cell carcinoma. ISRN Dermatol. 2012;2012:132196. doi:10.5402/2012/132196.
Derrick EK, Smith R, Melcher DH, et al. The use of cytology in the diagnosis of basal cell carcinoma. Br J Dermatol. 1994;130:561–3.
Lemos MM, Kindblom LG, Meis-Kindblom JM, et al. Fine-needle aspiration features of pilomatrixoma. Cancer. 2001;93:252–6.
Gupta RK, Simpson J, Dowle C. The role of cytology in the diagnosis of Paget’s disease of the nipple. Pathology. 1996;28:248–50.
Vohra P, Ljung BM, Miller TR, et al. Paget’s disease of the breast masquerading as squamous cell carcinoma on cytology: a case report. Diagn Cytopathol. 2012;40:1015–8.
Dubb M, Michelow P. Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol. 2009;53:179–82.
Varsa EW, Jordan SW. Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. Acta Cytol. 1990;34:275–7.
Yu L, Olsen S, Lowe L, et al. Fine-needle aspiration cytology of metastatic eccrine porocarcinoma. Diagn Cytopathol. 2009;37:755–8.
Sirikanjanapong S, Seymour AW, Amin B. Cytologic features of microcystic adnexal carcinoma. Cytojournal. 2011;8:5. doi:10.4103/1742-6413.77285.
Gangane N, Joshi D, Sharma SM. Cytomorphological diagnosis of malignant eccrine tumors: report of two cases. Diagn Cytopathol. 2008;36:801–4.
Jain P, Nanda A, Handa U, et al. FNA diagnosis of recurrent sebaceous carcinoma. Diagn Cytopathol. 2006;34:124–6.
Bonadio J, Armstrong W, Gu M. Eccrine porocarcinoma: report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry. Acta Cytol. 2006;50:476–80.
Kumar N, Verma K. Fine needle aspiration (FNA) cytology of pilomatrixoma. Cytopathology. 1996;7:125–31.
Bhadani PP, Sen R, Bhadani UK, et al. Is fine needle aspiration cytology (FNA) useful in skin adnexal masses? A study on 5 cases of pilomatixoma. Indian J Pathol Microbiol. 2007;50:411–4.
Perez-Guillermo M, Garcia Solano J, Acosta Ortega J. Pilomatrixoma: a diagnostic pitfall in fine-needle aspiration biopsies. A review from a small county hospital. Ann Diagn Pathol. 2005;9:182–3.
Wang J, Cobb CJ, Martin SE, et al. Pilomatrixoma: clinicopathologic study of 51 cases with emphasis on cytologic features. Diagn Cytopathol. 2002;27:167–72.
Viero RM, Tani E, Skoog L. Fine needle aspiration (FNA) cytology of pilomatrixoma: report of 14 cases and review of the literature. Cytopathology. 1999;10:263–9.
Domanski HA, Domanski AM. Cytology of pilomatrixoma (calcifying epithelioma of Malherbe) in fine needle aspirates. Acta Cytol. 1997;41:771–7.
Seili-Bekafigo I, Jonjić N, Stemberger C, Rajković-Molek K. Additional cytomorphological criteria in diagnosis of pilomatricoma—benign tumor with bad reputation. Coll Antropol. 2010;34:117–22.
Dubb M, Michelow P. Fine needle aspiration cytology of pilomatrixoma and differential diagnoses. Acta Cytol. 2009;53:683–8.
Dey P, Jogai S, Amir T, Temim L. Fine-needle aspiration cytology of Merkel cell carcinoma. Diagn Cytopathol. 2004;31:364–5.
Kabukcuoglu F, Sungun A, Polat N, et al. Fine needle aspiration cytology of Merkel cell carcinoma. Acta Cytol. 2003;47:311–3.
Hallman JR, Shaw JA, Geisinger KR, et al. Cytomorphologic features of Merkel cell carcinoma in fine needle aspiration biopsies. A study of two atypical cases. Acta Cytol. 2000;44:185–93.
Collins BT, Elmberger PG, Tani EM, et al. Fine-needle aspiration of Merkel cell carcinoma of the skin with cytomorphology and immunocytochemical correlation. Diagn Cytopathol. 1998;18:251–7.
Bechert CJ, Schnadig V, Nawgiri R. The Merkel cell carcinoma challenge: a review from the fine needle aspiration service. Cancer Cytopathol. 2013;121(4):179–88. doi:10.1002/cncy.21237.
Righi A, Asioli S, Caliendo V, et al. An ultrasonography–cytology protocol for the diagnostic management of regional nodes in a subset of patients with Merkel cell carcinoma of the skin. Br J Dermatol. 2013;168(3):563–70.
Stoll L, Mudali S, Ali SZ. Merkel cell carcinoma metastatic to the thyroid gland: aspiration findings and differential diagnosis. Diagn Cytopathol. 2010;38:754–7.
Ostović KT, Haris V, Miletić Z, et al. Fine needle aspiration cytology of metastatic Merkel cell carcinoma. Coll Antropol. 2010;34:691–6.
Dim DC, Nugent SL, Darwin P, Peng HQ. Metastatic merkel cell carcinoma of the pancreas mimicking primary pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report. Acta Cytol. 2009;53:223–8.
Suciu V, Botan E, Valent A, et al. The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of Merkel cell carcinoma. Cytopathology. 2008;19:48–51.
Vesoulis Z, Cunliffe C. Fine-needle aspiration biopsy of postradiation epithelioid angiosarcoma of breast. Diagn Cytopathol. 2000;22:172–5.
Boucher LD, Swanson PE, Stanley MW, et al. Cytology of angiosarcoma. Findings in fourteen fine-needle aspiration biopsy specimens and one pleural fluid specimen. Am J Clin Pathol. 2000;114:210–9.
Pohar-Marinsek Z, Lamovec J. Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology. 2010;21:311–9.
Gamborino E, Carrilho C, Ferro J, et al. Fine-needle aspiration diagnosis of Kaposi’s sarcoma in a developing country. Diagn Cytopathol. 2000;23:322–5.
Mallik MK, Das DK, Francis IM, et al. Fine needle aspiration cytology diagnosis of a cutaneous granular cell tumor in a 7-year-old child. A case report. Acta Cytol. 2001;45:263–6.
Wieczorek TJ, Krane JF, Domanski HA, et al. Cytologic findings in granular cell tumors, with emphasis on the diagnosis of malignant granular cell tumor by fine-needle aspiration biopsy. Cancer. 2001;93:398–408.
Klijanienko J, Caillaud JM, Lagace R. Fine-needle aspiration of primary and recurrent benign fibrous histiocytoma: classic, aneurysmal, and myxoid variants. Diagn Cytopathol. 2004;31:387–91.
Stewart CJ, Jackson R, Farquharson M, Richmond J. Fine-needle aspiration cytology of extranodal lymphoma. Diagn Cytopathol. 1998;19:260–6.
Mathiot C, Decaudin D, Klijanienko J, et al. Fine-needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions. Diagn Cytopathol. 2006;34:472–8.
Manosca F, Ariga R, Bengana C, et al. Fine-needle aspiration of subcutaneous panniculitis-like T-cell lymphoma. Diagn Cytopathol. 2004;31:338–9.
Tao J, Wu M, Fuchs A, Wasserman P. Fine-needle aspiration of granulocytic sarcomas: a morphologic and immunophenotypic study of seven cases. Ann Diagn Pathol. 2000;4:17–22.
Nagarajarao HS, Akhtar I, Heard K, Baliga M. Unusual presentation of chronic myelogenous leukemia as multiple skin chloromas: report of a case with clinical and cytologic correlation. Acta Cytol. 2009;53:235–8.
Abu-Hilal M, Newman JS. Sister Mary Joseph and her nodule: historical and clinical perspective. Am J Med Sci. 2009;337:271–3.
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Domanski, H.A., Stanley, D.E. (2014). Skin and Subcutis. In: Domanski, H. (eds) Atlas of Fine Needle Aspiration Cytology. Springer, London. https://doi.org/10.1007/978-1-4471-2446-7_14
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DOI: https://doi.org/10.1007/978-1-4471-2446-7_14
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