Advertisement

Sulthiame

  • P. N. Patsalos
Chapter

Abstract

Antacids containing magnesium trisilicate can decrease the oral bioavailability of sulthiame by up to 73 %, while antacids containing bismuth oxycarbonate and magnesium oxide can decrease the oral bioavailability of sulthiame by <105 %. To avoid problems, administration of sulthiame and antacids should be separated by at least 2 h [1].

Keywords

Public Health Oral Bioavailability Magnesium Trisilicate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    Naggar VF, Khalil SA. The in vitro adsorption of some antiepileptics on antacids. Pharmazie. 1978;33:593–5.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • P. N. Patsalos
    • 1
    • 2
  1. 1.UCL-Institute of Neurology Department of Clinical and Experimental EpilepsyLondonLondon
  2. 2.Epilepsy Society Chalfont Centre for EpilepsyBuckinghamshireUK

Personalised recommendations