• P. N. Patsalos


Antacids containing magnesium trisilicate can decrease the oral bioavailability of sulthiame by up to 73 %, while antacids containing bismuth oxycarbonate and magnesium oxide can decrease the oral bioavailability of sulthiame by <105 %. To avoid problems, administration of sulthiame and antacids should be separated by at least 2 h [1].


Public Health Oral Bioavailability Magnesium Trisilicate 
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  1. 1.
    Naggar VF, Khalil SA. The in vitro adsorption of some antiepileptics on antacids. Pharmazie. 1978;33:593–5.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • P. N. Patsalos
    • 1
    • 2
  1. 1.UCL-Institute of Neurology Department of Clinical and Experimental EpilepsyLondonLondon
  2. 2.Epilepsy Society Chalfont Centre for EpilepsyBuckinghamshireUK

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