Antacids containing magnesium trisilicate can decrease the oral bioavailability of sulthiame by up to 73 %, while antacids containing bismuth oxycarbonate and magnesium oxide can decrease the oral bioavailability of sulthiame by <105 %. To avoid problems, administration of sulthiame and antacids should be separated by at least 2 h .
Public Health Oral Bioavailability Magnesium Trisilicate
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