Abstract
Acetaminophen can decrease mean plasma lamotrigine AUC values by 20 % and mean elimination half-life values by 15 % and enhances the urinary elimination of lamotrigine via an unknown mechanism [1].
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References
Depot M, Powell JR, Messenheimer JA, Cloutier G, Dalton MJ. Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine. Clin Pharmacol Ther. 1990;48:346–55.
Haan GJD, Edelbroek P, Bartels C. Changes in lamotrigine pharmacokinetics induced by antitubercular drugs. Epilepsia. 2010;51(Supp. 4):26.
Ebert U, Thong NQ, Oertel R, Kirch W. Effects of rifampicin and cimetidine on pharmacokinetics and pharmacodynamics of Âlamotrigine in healthy volunteers. Eur J Clin Pharmacol. 2000;56:299–304.
Ulivelli M, Rubegni P, Nuti D, Bartalini S, Giannini S, Rossi S. Clinical evidence of fluconazole-induced carbamazepine toxicity. J Neurol. 2004;251:622–3.
Burger DM, Huisman A, van Ewijk N, Neisingh H, van Uden P, Rongen GA, Koopmans P, Bertz RJ. The effect of atazanavir and atazanavir/ritonavir on UDP-glucuronosyltransferase using lamotrigine as a phenotypic probe. Clin Pharmacol Ther. 2008;84:698–703.
Van der Lee MJ, Dawood L, ter Hofstede HJM, de Graaff-Teulen MJA, van Ewijk-Beneken-Kolmer EWJ, Caliskan-Yassen N, Koopmans PP, Burger DM. Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy volunteers. Clin Pharmacol Ther. 2006;80:159–68.
van Luin M, Colbers A, Verwey-van Wissen CPWGM, van Ewijk-Beneken-Kolmer EWJ, van der Kolk M, Hoitsam A, Gomesda Silva H, Gomes da Silva H, Burger DM. The effect of raltegravir on the glucuronidation of lamotrigine. J Clin Pharmacol. 2009;49:1220–7.
Normann C, Hummel B, Scharer LO, Horn M, Grunze H, Walden J. Lamotrigine as adjunctive to paroxetine in acute depression: a Âplacebo-controlled, double-blind study. J Clin Psychiatry. 2002;63:337–44.
Kaufman KR, Gerner R. Lamotrigine toxicity secondary to sertraline. Seizure. 1998;7:163–5.
Schieber FC, Boulton DW, Balch AH, Croop R, Mallikaarjun S, Benson J, Carlson BX. A non-randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady-state pharmacokinetics of lamotrigine in patients with bipolar I disorder. Hum Psychopharmacol. 2009;24:145–52.
Reimers A, Skogvoll E, Sund JK, Spiget O. Drug interaction between lamotrigine and psychoactive drugs: evidence from a therapeutic drug monitoring service. J Clin Psychopharmacol. 2005;25:342–8.
Sidhu J, Job S, Bullman J, Francis E, Abbott R, Asher J, Theis JGW. Pharmacokinetics and tolerability of lamotrigine and olanzapine coadministered to healthy subjects. Br J Clin Pharmacol. 2006;61:420–6.
Sabers A, Ohman I, Christensen J, Tomson T. Oral contraceptives reduce lamotrigine plasma levels. Neurology. 2003;61:570–1.
Odishaw J, Chen C. Effects of steady-state bupropion on the pharmacokinetics of lamotrigine in healthy subjects. Pharmacotherapy. 2000;20:1448–14453.
Bigham S, McGuigan C, MacDonald BK. Reduced absorption of lipophilic anti-epileptic medications when used concomitantly with the anti-obesity drug orlistat. Epilepsia. 2006;47:2207.
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Patsalos, P.N. (2013). Lamotrigine. In: Antiepileptic Drug Interactions. Springer, London. https://doi.org/10.1007/978-1-4471-2434-4_37
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DOI: https://doi.org/10.1007/978-1-4471-2434-4_37
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