Abstract
Antacids (Maalox aluminumhydroxide/magnesium hydroxide) can reduce the oral bioavailability of gabapentin by 20 %. To avoid problems, administration of gabapentin and antacids should be separated by at least 2 h [1].
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References
Busch JA, Radulovic LL, Bockbrader HN, Underwood BA, Sedman AJ, Chang T. Effect of Maalox TC on single-dose pharmacokinetics of gabapentin capsules in healthy subjects. Pharm Res. 1992;9 (Suppl 2):S315.
Sternieri E, Coccio CPR, Pinetti D, Guerzoni S, Ferrari A. Pharmacokinetics and interactions of headache medications, part II: prophylactic treatments. Expert Opin Drug Metab Toxicol. 2006;2:981–1007.
Lal R, Sukbuntherng J, Luo W, Vicente V, Blumenthal R, Ho J, Cundy KC. Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transporter prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010;69:498–507.
Busch JA, Bockbrader HN, Randinitis EJ, Chang T, Welling PG, Reece PA, Underwood B, Sedman AJ, Vollmer KO, Turck D. Lack of clinically significant drug interactions with Neurontin (Gabapentin). In: 20th international epilepsy congress, Oslo, July 1993, Abstract 013958.
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Patsalos, P.N. (2013). Gabapentin. In: Antiepileptic Drug Interactions. Springer, London. https://doi.org/10.1007/978-1-4471-2434-4_35
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DOI: https://doi.org/10.1007/978-1-4471-2434-4_35
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