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Vigabatrin

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Antiepileptic Drug Interactions
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Abstract

Vigabatrin (Fig. 1) corresponds chemically to (±)-amino-hex-5-enoic acid with an empirical formula of C6H11NO2 and a molecular weight of 129.2.

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References

  1. Armijo JA, Cuadrado A, Bravo J, Arteaga R. Vigabatrin serum concentration to dosage ratio: influence of age and associated antiepileptic drugs. Ther Drug Monit. 1997;19:491–8.

    Article  PubMed  CAS  Google Scholar 

  2. Brodie MJ, Mumford JP. Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res. 1999;34:199–205.

    Article  Google Scholar 

  3. Reidenberg P, Glue P, Banfield C, Colucci R, Meehan J, Rey E, Radwanski E, Nomeir A, Lim J, Lin C, Guillaume M, Affrime MB. Pharmacokinetic interaction studies between felbamate and vigabatrin. Br J Clin Pharmacol. 1995;40:157–60.

    Article  PubMed  CAS  Google Scholar 

  4. Stolarek I, Blacklaw J, Forrest G, Brodie MJ. Vigabatrin and lamotrigine in refractory epilepsy. J Neurol Neurosurg Psychiatry. 1994;57:921–4.

    Article  PubMed  CAS  Google Scholar 

  5. Perucca E, Baltes E, Ledent E. Levetiracetam: absence of pharmacokinetic interactions with other antiepileptic drugs (AEDs). Epilepsia. 2000;41 (Suppl 6):150.

    Google Scholar 

  6. Spence SJ, Nakagawa J, Sankar R, Shields WD. Phenobarbital interferes with the efficacy of vigabatrin in treating infantile spasms in patients with tuberous sclerosis. Epilepsia. 2000;41 (Suppl 7):189.

    Google Scholar 

  7. Leach JP, Brodie MJ. Synergism with GABAergic drugs in refractory epilepsy. Lancet. 1994;343:1650.

    Article  PubMed  CAS  Google Scholar 

  8. Armijo JA, Arteaga R, Valdizan EM, Herranz JL. Coadministration of vigabatrin and valproate in children with refractory epilepsy. Clin Neuropharmacol. 1992;15:459–69.

    Article  PubMed  CAS  Google Scholar 

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Patsalos, P.N. (2013). Vigabatrin. In: Antiepileptic Drug Interactions. Springer, London. https://doi.org/10.1007/978-1-4471-2434-4_26

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  • DOI: https://doi.org/10.1007/978-1-4471-2434-4_26

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  • Online ISBN: 978-1-4471-2434-4

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