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Cardiac Pathology pp 163–181Cite as

Transplant Pathology

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Abstract

This chapter provides a general overview of the diagnosis of acute cellular rejection, antibody-mediated rejection, and chronic vascular rejection (graft vasculopathy) and how to differentiate from the mimics of rejection. Also described are other entities encountered in cardiac transplant recipients including peritransplant injury both in endomyocardial biopsies and failed allografts, infections, and post-transplant lymphoproliferative disorders. The examination of a failed allograft is discussed.

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References

  1. Hamour IM, Khaghani A, Kanagala PK, Mitchell AG, Banner NR. Current outcome of heart transplantation: a 10-year single centre perspective and review. QJM. 2010;104:335–43.

    Article  PubMed  Google Scholar 

  2. Crespo-Leiro MG, Barge-Caballero E, Marzoa-Rivas R, Paniagua-Martin MJ. Heart transplantation. Curr Opin Organ Transplant. 2010;15:633–8.

    Article  PubMed  Google Scholar 

  3. Tan CD, Baldwin III WM, Rodriguez ER. Update on cardiac transplantation pathology. Arch Pathol Lab Med. 2007;131:1169–91.

    PubMed  Google Scholar 

  4. Billingham ME. Some recent advances in cardiac pathology. Hum Pathol. 1979;10:367–86.

    Article  PubMed  CAS  Google Scholar 

  5. Billingham ME, Cary NR, Hammond ME. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant. 1990;9:587–93.

    PubMed  CAS  Google Scholar 

  6. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710–20.

    Article  PubMed  Google Scholar 

  7. Spiegelhalter DJ, Stovin PG. An analysis of repeated biopsies following cardiac transplantation. Stat Med. 1983;2:33–40.

    Article  PubMed  CAS  Google Scholar 

  8. Sharples LD, Cary NR, Large SR, Wallwork J. Error rates with which endomyocardial biopsy specimens are graded for rejection after cardiac transplantation. Am J Cardiol. 1992;70:527–30.

    Article  PubMed  CAS  Google Scholar 

  9. Kobashigawa J, Crespo-Leiro MG, Ensminger SM, et al. Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2011;30:252–69.

    Article  PubMed  Google Scholar 

  10. Berry G, Angelini A, Burke M, et al. The ISHLT working formulation for pathological diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005–2011). J Heart Lung Transplant. 2011;30(6):601–11.

    Google Scholar 

  11. Behr TM, Feucht HE, Richter K, et al. Detection of humoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies. J Heart Lung Transplant. 1999;18:904–12.

    Article  PubMed  CAS  Google Scholar 

  12. Feucht HE, Schneeberger H, Hillebrand G, et al. Capillary deposition of C4d complement fragment and early renal graft loss. Kidney Int. 1993;43:1333–8.

    Article  PubMed  CAS  Google Scholar 

  13. Rodriguez ER, Skojec DV, Tan CD, et al. Antibody-mediated rejection in human cardiac allografts: evaluation of immunoglobulins and complement activation products C4d and C3d as markers. Am J Transplant. 2005;5:2778–85.

    Article  PubMed  CAS  Google Scholar 

  14. Reed EF, Demetris AJ, Hammond E, et al. Acute antibody-mediated rejection of cardiac transplants. J Heart Lung Transplant. 2006;25:153–9.

    Article  PubMed  Google Scholar 

  15. Stewart S, Cary NRB. The pathology of heart and lung transplantation. Curr Diagn Pathol. 1996;3:69–79.

    Article  CAS  Google Scholar 

  16. Suvarna SK, Kennedy A, Ciulli F, Locke TJ. Revision of the 1990 working formulation for cardiac allograft rejection: the Sheffield experience. Heart. 1998;79:432–6.

    PubMed  CAS  Google Scholar 

  17. Maleszewski JJ, Kucirka LM, Segev DL, Halushka MK. Survey of current practice related to grading of rejection in cardiac transplant recipients in North America. Cardiovasc Pathol. 2011;20:261–5.

    Article  PubMed  Google Scholar 

  18. Hook S, Caple JF, McMahon JT, Myles JL, Ratliff NB. Comparison of myocardial cell injury in acute cellular rejection versus acute vascular rejection in cyclosporine-treated heart transplants. J Heart Lung Transplant. 1995;14:351–8.

    PubMed  CAS  Google Scholar 

  19. Howie AJ. C9 immunohistology in detection of myocardial infarction. J Pathol. 2001;193:421.

    Article  PubMed  CAS  Google Scholar 

  20. Robert-Offerman SR, Leers MP, van Suylen RJ, Nap M, Daemen MJ, Theunissen PH. Evaluation of the membrane attack complex of complement for the detection of a recent myocardial infarction in man. J Pathol. 2000;191:48–53.

    Article  PubMed  CAS  Google Scholar 

  21. Yasojima K, Schwab C, McGeer EG, McGeer PL. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circ Res. 1998;83:860–9.

    Article  PubMed  CAS  Google Scholar 

  22. Fishbein MC, Kobashigawa J. Biopsy-negative cardiac transplant rejection: etiology, diagnosis, and therapy. Curr Opin Cardiol. 2004;19:166–9.

    Article  PubMed  Google Scholar 

  23. Hammond EH, Hansen JK, Spencer LS, Jensen A, Yowell RL. Immunofluorescence of endomyocardial biopsy specimens: methods and interpretation. J Heart Lung Transplant. 1993;12:S113–24.

    PubMed  CAS  Google Scholar 

  24. Hammond EH, Yowell RL, Nunoda S, et al. Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. J Heart Transplant. 1989;8:430–43.

    PubMed  CAS  Google Scholar 

  25. Olsen SL, Wagoner LE, Hammond EH, et al. Vascular rejection in heart transplantation: clinical correlation, treatment options, and future considerations. J Heart Lung Transplant. 1993;12:S135–42.

    PubMed  CAS  Google Scholar 

  26. Bonnaud EN, Lewis NP, Masek MA, Billingham ME. Reliability and usefulness of immunofluorescence in heart transplantation. J Heart Lung Transplant. 1995;14:163–71.

    PubMed  CAS  Google Scholar 

  27. Crespo M, Pascual M, Tolkoff-Rubin N. Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics. Transplantation. 2001;71:652–8.

    Article  PubMed  CAS  Google Scholar 

  28. Chantranuwat C, Qiao JH, Kobashigawa J, Hong L, Shintaku P, Fishbein MC. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft endomyocardial biopsies: comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol. 2004;12:166–71.

    PubMed  Google Scholar 

  29. Miller DV, Roden AC, Gamez JD, Tazelaar HD. Detection of C4d deposition in cardiac allografts: a comparative study of immunofluorescence and immunoperoxidase methods. Arch Pathol Lab Med. 2010;134:1679–84.

    PubMed  Google Scholar 

  30. Lones MA, Czer LS, Trento A, Harasty D, Miller JM, Fishbein MC. Clinical-pathologic features of humoral rejection in cardiac allografts: a study in 81 consecutive patients. J Heart Lung Transplant. 1995;14:151–62.

    PubMed  CAS  Google Scholar 

  31. Ratliff NB, McMahon JT. Activation of intravascular macrophages within myocardial small vessels is a feature of acute vascular rejection in human heart transplants. J Heart Lung Transplant. 1995;14:338–45.

    PubMed  CAS  Google Scholar 

  32. Takemoto SK, Zeevi A, Feng S, et al. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant. 2004;4:1033–41.

    Article  PubMed  CAS  Google Scholar 

  33. Wu GW, Kobashigawa JA, Fishbein MC, et al. Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes. J Heart Lung Transplant. 2009;28:417–22.

    Article  PubMed  Google Scholar 

  34. Tan CD, Sokos GG, Pidwell DJ, et al. Correlation of donor-specific antibodies, complement and its regulators with graft dysfunction in cardiac antibody-mediated rejection. Am J Transplant. 2009;9:2075–84.

    Article  PubMed  CAS  Google Scholar 

  35. Kfoury AG, Hammond ME, Snow GL, et al. Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejection. J Heart Lung Transplant. 2009;28:781–4.

    Article  PubMed  Google Scholar 

  36. Forbes RD, Rowan RA, Billingham ME. Endocardial infiltrates in human heart transplants: a serial biopsy analysis comparing four immunosuppression protocols. Hum Pathol. 1990;21:850–5.

    Article  PubMed  CAS  Google Scholar 

  37. Gajjar NA, Kobashigawa JA, Laks H, Espejo-Vassilakis M, Fishbein MC. FK506 vs. cyclosporin. Pathologic findings in 1067 endomyocardial biopsies. Cardiovasc Pathol. 2003;12:73–6.

    Article  PubMed  CAS  Google Scholar 

  38. Barone JH, Fishbein MC, Czer LS, Blanche C, Trento A, Luthringer DJ. Absence of endocardial lymphoid infiltrates (Quilty lesions) in nonheart transplant recipients treated with cyclosporine. J Heart Lung Transplant. 1997;16:600–3.

    PubMed  CAS  Google Scholar 

  39. Sattar HA, Husain AN, Kim AY, Krausz T. The presence of a CD21+ follicular dendritic cell network distinguishes invasive Quilty lesions from cardiac acute cellular rejection. Am J Surg Pathol. 2006;30:1008–13.

    Article  PubMed  Google Scholar 

  40. Di Carlo E, D’Antuono T, Contento S, Di NM, Ballone E, Sorrentino C. Quilty effect has the features of lymphoid neogenesis and shares CXCL13-CXCR5 pathway with recurrent acute cardiac rejections. Am J Transplant. 2007;7:201–10.

    Article  PubMed  CAS  Google Scholar 

  41. Marboe CC, Billingham M, Eisen H, et al. Nodular endocardial infiltrates (Quilty lesions) cause significant variability in diagnosis of ISHLT Grade 2 and 3A rejection in cardiac allograft recipients. J Heart Lung Transplant. 2005;24:S219–26.

    Article  PubMed  Google Scholar 

  42. Hiemann NE, Knosalla C, Wellnhofer E, Lehmkuhl HB, Hetzer R, Meyer R. Quilty in biopsy is associated with poor prognosis after heart transplantation. Transpl Immunol. 2008;19:209–14.

    Article  PubMed  CAS  Google Scholar 

  43. Hiemann NE, Knosalla C, Wellnhofer E, Lehmkuhl HB, Hetzer R, Meyer R. Quilty indicates increased risk for microvasculopathy and poor survival after heart transplantation. J Heart Lung Transplant. 2008;27:289–96.

    Article  PubMed  Google Scholar 

  44. Chantranuwat C, Blakey JD, Kobashigawa JA, et al. Sudden, unexpected death in cardiac transplant recipients: an autopsy study. J Heart Lung Transplant. 2004;23:683–9.

    Article  PubMed  Google Scholar 

  45. Yamani MH, Ratliff NB, Starling RC, et al. Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of coronary vasculopathy. J Heart Lung Transplant. 2003;22:687–90.

    Article  PubMed  Google Scholar 

  46. Zakliczynski M, Nozynski J, Konecka-Mrowka D, et al. Quilty effect correlates with biopsy-proven acute cellular rejection but does not predict transplanted heart coronary artery vasculopathy. J Heart Lung Transplant. 2009;28:255–9.

    Article  PubMed  Google Scholar 

  47. Sibley RK, Olivari MT, Ring WS, Bolman RM. Endomyocardial biopsy in the cardiac allograft recipient. A review of 570 biopsies. Ann Surg. 1986;203:177–87.

    Article  PubMed  CAS  Google Scholar 

  48. Connor RC. Heart damage associated with intracranial lesions. Br Med J. 1968;3:29–31.

    Article  PubMed  CAS  Google Scholar 

  49. Connor RC. Focal myocytolysis and fuchsinophilic degeneration of the myocardium of patients dying with various brain lesions. Ann N Y Acad Sci. 1969;156:261–70.

    Article  PubMed  CAS  Google Scholar 

  50. Connor RC. Myocardial damage secondary to brain lesions. Am Heart J. 1969;78:145–8.

    Article  PubMed  CAS  Google Scholar 

  51. Connor RC. Fuchsinophilic degeneration of myocardium in patients with intracranial lesions. Br Heart J. 1970;32:81–4.

    Article  PubMed  CAS  Google Scholar 

  52. Haddad F, Deuse T, Pham M, et al. Changing trends in infectious disease in heart transplantation. J Heart Lung Transplant. 2010;29:306–15.

    Article  PubMed  Google Scholar 

  53. Breinholt JP, Moulik M, Dreyer WJ, et al. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010;29:739–46.

    Article  PubMed  Google Scholar 

  54. Moulik M, Breinholt JP, Dreyer WJ, et al. Viral endomyocardial infection is an independent predictor and potentially treatable risk factor for graft loss and coronary vasculopathy in pediatric cardiac transplant recipients. J Am Coll Cardiol. 2010;56:582–92.

    Article  PubMed  Google Scholar 

  55. Kotton CN. Update on infectious diseases in pediatric solid organ transplantation. Curr Opin Organ Transplant. 2008;13:500–5.

    Article  PubMed  Google Scholar 

  56. Casadei D. Chagas’ disease and solid organ transplantation. Transplant Proc. 2010;42:3354–9.

    Article  PubMed  Google Scholar 

  57. Kotton CN, Lattes R. Parasitic infections in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S234–51.

    Article  PubMed  Google Scholar 

  58. Derouin F, Pelloux H. Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect. 2008;14:1089–101.

    Article  PubMed  CAS  Google Scholar 

  59. Sanchez MA, Debrunner M, Cox E, Caldwell R. Acquired toxoplasmosis after orthotopic heart transplantation in a sulfonamide-allergic patient. Pediatr Cardiol. 2011;32:91–3.

    Article  Google Scholar 

  60. Parker A, Bowles K, Bradley JA, et al. Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients – BCSH and BTS guidelines. Br J Haematol. 2010;149:675–92.

    Article  PubMed  Google Scholar 

  61. Tsao L, Hsi ED. The clinicopathologic spectrum of posttransplantation lymphoproliferative disorders. Arch Pathol Lab Med. 2007;131:1209–18.

    PubMed  Google Scholar 

  62. Grivas PD. Post-transplantation lymphoproliferative disorder (PTLD) twenty years after heart transplantation: a case report and review of the literature. Med Oncol. 2011;28:829–34.

    Article  PubMed  Google Scholar 

  63. Manlhiot C, Pollock-Barziv SM, Holmes C, et al. Post-transplant lymphoproliferative disorder in pediatric heart transplant recipients. J Heart Lung Transplant. 2010;29:648–57.

    Article  PubMed  Google Scholar 

  64. Mucha K, Foroncewicz B, Ziarkiewicz-Wroblewska B, Krawczyk M, Lerut J, Paczek L. Post-transplant lymphoproliferative disorder in view of the new WHO classification: a more rational approach to a protean disease? Nephrol Dial Transplant. 2010;25:2089–98.

    Article  PubMed  Google Scholar 

  65. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: World Health Organization; 2008.

    Google Scholar 

  66. Turillazzi E, Pennella A, Di GG, Neri M, Fineschi V. Post-transplant lymphoproliferative disorder in the heart late after heterotopic transplantation: autopsy findings. J Heart Lung Transplant. 2010;29:904–6.

    Article  PubMed  Google Scholar 

  67. Luk A, Metawee M, Ahn E, Gustafsson F, Ross H, Butany J. Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy. Can J Cardiol. 2009;25:e48–54.

    Article  PubMed  Google Scholar 

  68. Neil D. Recurrent and de novo disease in kidney, heart, lung, pancreas and intestinal transplants. Curr Opin Organ Transpl. 2006;11:289–95.

    Article  Google Scholar 

  69. Alloni A, Pellegrini C, Ragni T, et al. Heart transplantation in patients with amyloidosis: single-center experience. Transplant Proc. 2004;36:643–4.

    Article  PubMed  CAS  Google Scholar 

  70. Dubrey SW, Burke MM, Hawkins PN, Banner NR. Cardiac transplantation for amyloid heart disease: the United Kingdom experience. J Heart Lung Transplant. 2004;23:1142–53.

    Article  PubMed  Google Scholar 

  71. Kristen AV, Meyer FJ, Perz JB, et al. Risk stratification in cardiac amyloidosis: novel approaches. Transplantation. 2005;80:S151–5.

    Article  PubMed  Google Scholar 

  72. Kristen AV, Sack FU, Schonland SO, et al. Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis. Eur J Heart Fail. 2009;11:1014–20.

    Article  PubMed  CAS  Google Scholar 

  73. Mignot A, Varnous S, Redonnet M, et al. Heart transplantation in systemic (AL) amyloidosis: A retrospective study of eight French patients. Arch Cardiovasc Dis. 2008;101:523–32.

    Article  PubMed  Google Scholar 

  74. Sattianayagam PT, Gibbs SD, Pinney JH, et al. Solid organ transplantation in AL amyloidosis. Am J Transplant. 2010;10:2124–31.

    Article  PubMed  CAS  Google Scholar 

  75. Moloney ED, Egan JJ, Kelly P, Wood AE, Cooper Jr LT. Transplantation for myocarditis: a controversy revisited. J Heart Lung Transplant. 2005;24:1103–10.

    Article  PubMed  Google Scholar 

  76. Luk A, Lee A, Ahn E, Soor GS, Ross HJ, Butany J. Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. Can J Cardiol. 2010;26:e273–5.

    Article  PubMed  Google Scholar 

  77. Oni AA, Hershberger RE, Norman DJ, et al. Recurrence of sarcoidosis in a cardiac allograft: control with augmented corticosteroids. J Heart Lung Transplant. 1992;11:367–9.

    PubMed  CAS  Google Scholar 

  78. Strecker T, Zimmermann I, Wiest GH. Pulmonary and cardiac recurrence of sarcoidosis in a heart transplant recipient. Dtsch Med Wochenschr. 2007;132:1159–62.

    Article  PubMed  Google Scholar 

  79. Yager JE, Hernandez AF, Steenbergen C, et al. Recurrence of cardiac sarcoidosis in a heart transplant recipient. J Heart Lung Transplant. 2005;24:1988–90.

    Article  PubMed  Google Scholar 

  80. Vassalli G, Gallino A, Weis M, et al. Alloimmunity and nonimmunologic risk factors in cardiac allograft vasculopathy. Eur Heart J. 2003;24:1180–8.

    Article  PubMed  CAS  Google Scholar 

  81. Demetris AJ, Zerbe T, Banner B. Morphology of solid organ allograft arteriopathy: identification of proliferating intimal cell populations. Transplant Proc. 1989;21:3667–9.

    PubMed  CAS  Google Scholar 

  82. Billingham ME. Cardiac transplant atherosclerosis. Transplant Proc. 1987;19:19–25.

    PubMed  CAS  Google Scholar 

  83. Billingham ME. Graft coronary disease: the lesions and the patients. Transplant Proc. 1989;21:3665–6.

    PubMed  CAS  Google Scholar 

  84. Eisen HJ. Pathogenesis and management of cardiac allograft vasculopathy. Curr Opin Organ Transpl. 2004;9:448–52.

    Article  Google Scholar 

  85. Pratschke J, Volk HD. Brain death-associated ischemia and reperfusion injury. Curr Opin Organ Transpl. 2004;9:153–8.

    Article  Google Scholar 

  86. Mehra MR, Uber PA, Ventura HO, Scott RL, Park MH. The impact of mode of donor brain death on cardiac allograft vasculopathy: an intravascular ultrasound study. J Am Coll Cardiol. 2004;43:806–10.

    Article  PubMed  Google Scholar 

  87. Cohen O, De La Zerda DJ, Beygui R, Hekmat D, Laks H. Donor brain death mechanisms and outcomes after heart transplantation. Transplant Proc. 2007;39:2964–9.

    Article  PubMed  CAS  Google Scholar 

  88. Neil DA, Lynch SV, Hardie IR, Effeney DJ. Cold storage preservation and warm ischaemic injury to isolated arterial segments: endothelial cell injury. Am J Transplant. 2002;2:400–9.

    Article  PubMed  Google Scholar 

  89. Neil DA, Maguire SH, Walsh M, Lynch SV, Hardie IR, Effeney DJ. Progression of changes in arteries following cold storage preservation in UW and Collins solution in a syngeneic aortic transplant model. Transplant Proc. 1997;29:2561–2.

    Article  PubMed  CAS  Google Scholar 

  90. Hiemann NE, Musci M, Wellnhofer E, Meyer R, Hetzer R. Light microscopic biopsy findings after heart transplantation and possible links to development of graft vessel disease. Transplant Proc. 1999;31:149–51.

    Article  PubMed  CAS  Google Scholar 

  91. Koch A, Bingold TM, Oberlander J, et al. Capillary endothelia and cardiomyocytes differ in vulnerability to ischemia/reperfusion during clinical heart transplantation. Eur J Cardiothorac Surg. 2001;20:996–1001.

    Article  PubMed  CAS  Google Scholar 

  92. Kupiec-Weglinski JW. Ischemia and reperfusion injury. Curr Opin Organ Transpl. 2004;9:130–1.

    Article  Google Scholar 

  93. Logani S, Saltzman HE, Kurnik P, Eisen HJ, Ledley GS. Clinical utility of intravascular ultrasound in the assessment of coronary allograft vasculopathy: a review. J Interv Cardiol. 2011;24:9–14.

    Article  PubMed  Google Scholar 

  94. Stary HC, Blankenhorn DH, Chandler AB. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1992;85:391–405.

    Article  PubMed  CAS  Google Scholar 

  95. Gao SZ, Schroeder JS, Alderman EL, et al. Clinical and laboratory correlates of accelerated coronary artery disease in the cardiac transplant patient. Circulation. 1987;76:V56–61.

    PubMed  CAS  Google Scholar 

  96. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res. 2004;61:461–70.

    Article  PubMed  CAS  Google Scholar 

  97. Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol. 2010;106:360–8.

    Article  PubMed  Google Scholar 

  98. Nijboer WN, Schuurs TA, Van der Hoeven JAB, Ploeg RJ. Effect of brain death and donor treatment on organ inflammatory response and donor organ viability. Curr Opin Organ Transpl. 2004;9:110–5.

    Article  Google Scholar 

  99. Van der Hoeven JAB, Ploeg RJ. Effects of brain death on donor organ viability. Curr Opin Organ Transpl. 2001;6:75–82.

    Article  Google Scholar 

  100. Rodriguez-Sinovas A, Abdallah Y, Piper HM, Garcia-Dorado D. Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction. Heart Fail Rev. 2007;12:207–16.

    Article  PubMed  CAS  Google Scholar 

  101. Inserte J, Garcia-Dorado D, Ruiz-Meana M, et al. Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death. Cardiovasc Res. 2002;55:739–48.

    Article  PubMed  CAS  Google Scholar 

  102. Miller DL, Li P, Dou C, Armstrong WF, Gordon D. Evans blue staining of cardiomyocytes induced by myocardial contrast echocardiography in rats: evidence for necrosis instead of apoptosis. Ultrasound Med Biol. 2007;33:1988–96.

    Article  PubMed  Google Scholar 

  103. Boyle JJ, Rassl DM, Neil D, Suvarna K, Doran H. Heart dissection – explants post cardiac transplantation. In: Boyle JJ, editor. Tissue pathways for cardiovascular pathology. Royal College of Pathologists, London; 2008. http://www.rcpath.org/Resources/RCPath/Migrated%20Resources/Documents/G/g074tpcvsfinal.pdf p. 20–1.

  104. Boyle JJ, Rassl DM, Neil D, Suvarna K, Doran H. Autopsy ­cardiac dissection. In: Boyle JJ, editor. Tissue pathways for cardiovascular pathology. Royal College of Pathologists, London; 2008. http://www.rcpath.org/Resources/RCPath/Migrated%20Resources/Documents/G/g074tpcvsfinal.pdf p. 22–7.

  105. Basso C, Burke M, Fornes P, et al. Guidelines for autopsy investigation of sudden cardiac death. Virchows Arch. 2008;452:11–8.

    Article  PubMed  Google Scholar 

  106. Suvarna SK. National guidelines for adult autopsy cardiac dissection and diagnosis–are they achievable? A personal view. Histopathology. 2008;53:97–112.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cellular Pathology, Level − 1, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, B15 2WB, UK

    Desley A. H. Neil BMedSc, MBBS, Ph.D., FRCPath

  2. Department of Histopathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK

    Desley A. H. Neil BMedSc, MBBS, Ph.D., FRCPath

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Correspondence to Desley A. H. Neil BMedSc, MBBS, Ph.D., FRCPath .

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  1. , Department of Pathology, Northern General Hospital, Herries Road, Sheffield, S5 7AU, United Kingdom

    S. Kim Suvarna

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Neil, D.A.H. (2013). Transplant Pathology. In: Suvarna, S. (eds) Cardiac Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-2407-8_10

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