A Young Man with Blurred Vision and Foot Drop
POEMS is a rare disease involving a multiplicity of systems, resulting in a unique set of symptoms and signs as illustrated in this case. A high index of suspicion is needed to enable early diagnosis and institution of effective treatment before too much irreversible neurological deficit has accrued. Specialist tests and a specialist centre for treatment may be required.
KeywordsPOEMS VEGF CIDP Paraprotein Lambda light chains
- Kuwabara S, Dispenzieri A, Arimura K, Misawa S, Nakaseko C. Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome. Cochrane Database Syst Rev. 2012;6:CD006828. doi: 10.1002/14651858.CD006828.pub3.