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Effects of Metabolic Syndrome on Atherosclerosis in Childhood

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Pediatric Metabolic Syndrome

Abstract

Atherosclerosis is a chronic disease of the arterial wall that starts in childhood but does not usually manifest clinically until adulthood. Its progression depends on several risk factors, most of which are components of metabolic syndrome. In this chapter, we summarize the evidence of pediatric onset of atherosclerosis and discuss its pathogenesis. We also review the effects of various components of metabolic syndrome on the development of atherosclerosis and the strategies for stratifying and reducing the risk of atherosclerosis. A substantial amount of data confirms the early initiation of atherosclerosis. Therefore, earlier efforts to identify, prevent, and treat metabolic syndrome may improve the quality and length of life.

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Authors and Affiliations

  1. Division of Pediatric Cardiology, Department of Pediatrics, University of Miami/Jackson Memorial Hospital, Miami, FL, USA

    Muhammad Yasir Qureshi M.D.

  2. Division of Pediatric Clinical Research, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA

    Sarah E. Messiah M.D.

  3. Division of Pediatric Clinical Research, Department of Pediatrics, University of Miami Miller School of Medicine, Batchelor Children’s Research Institute, Miami, FL, USA

    Tracie L. Miller M.D.

  4. Department of Pediatrics, University of Miami Miller School of Medicine, 1601 NW 12th Avenue, 9th Floor, Miami, FL, 33136, USA

    Steven E. Lipshultz M.D.

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  1. Muhammad Yasir Qureshi M.D.
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  1. , Pediatrics, Miller School of Medicine, D820, Miami, 33101-6820, Florida, USA

    Steven E. Lipshultz

  2. , Pediatrics, Miller School of Medicine, 1580 NW 10th Avenue, Miami, 33130, USA

    Sarah E. Messiah

  3. , Pediatrics, Miller School of Medicine, 1580 NW 10th Avenue #123, Miami, 33101, USA

    Tracie L. Miller

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Qureshi, M.Y., Messiah, S.E., Miller, T.L., Lipshultz, S.E. (2012). Effects of Metabolic Syndrome on Atherosclerosis in Childhood. In: Lipshultz, S., Messiah, S., Miller, T. (eds) Pediatric Metabolic Syndrome. Springer, London. https://doi.org/10.1007/978-1-4471-2366-8_5

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