Cellular Origin of Grade II Gliomas

  • Pierre-Olivier Guichet
  • Jean-Philippe HugnotEmail author


Low-grade, diffuse gliomas comprise a heterogeneous group of tumors that display different phenotypes, genetic alterations, and clinical features. Important advances made over the past decade have significantly contributed to clarifying the cellular origin of these tumors. The identification of new markers for cells derived from the neural lineage combined with the detailed characterization of stem cell and progenitor cell populations that reside in the adult brain has fueled the development of original approaches to identify the cell type from which these tumors are derived. In this chapter, we will summarize our current knowledge in this dynamic field of research.


Oligodendroglioma Neural stem cells Oligodendrocyte progenitors Transgenic mice Low-grade diffuse gliomas Glia 


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.INSERM U1051, Université Montpellier 2, Institute for Neurosciences of Montpellier, Hôpital Saint EloiMontpellierFrance
  2. 2.Team “Brain Plasticity, Stem Cells and Glial Tumor”UM2-UM1-INSERM U1051, Institute of Neurosciences of MontpellierMontpellierFrance

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