Histological Classification

  • Valérie RigauEmail author


Glial tumors are difficult to classify. The lack of reproducibility between pathologists is proven, with a difference of interpretation between reaction cells and tumor cells, and between astrocytes and oligodendrocytes. This drawback does not exist in any other organ, and so far no immunohistochemical marker can make the distinction. This chapter on neuro-­oncopathology reviews the history of the different histological classifications used over time to try to perform the grading of gliomas, with special emphasis on the WHO classification which is considered as the gold standard but which has however several limitations. Finally, we discuss our experience with diffuse low-grade gliomas with regard to the proposal of a new intermediate grade.


Diffuse low-grade glioma Histological classification 


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Pathology, Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance
  2. 2.Team “Neuronal Death and Epilepsia”IGF CNRS UMR 5023-INSERM U661, UM1-UM2MontpellierFrance
  3. 3.National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Team “Brain Plasticity, Stem Cells and Glial Tumors”, Institute for Neurosciences of MontpellierMontpellier University Medical CenterMontpellierFrance
  4. 4.Cytology and Anatomical Pathology LaboratoryMontpellier University Medical CenterMontpellierFrance

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