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Magnetoencephalography, Functional Connectivity, and Neural Network Topology in Diffuse Low-Grade Gliomas

  • Jan J. HeimansEmail author
  • Jaap C. Reijneveld
  • Cornelis J. Stam
Chapter

Abstract

Structural as well as functional connectivity of the cerebral network may be affected by the presence of a brain tumor. Magnetoencephalography (MEG) is one of the methods to study functional connectivity. Within predefined, classical frequency bands, various resting-state network characteristics can be studied. These characteristics enable us to describe a network in terms of synchronization, clustering coefficient, and so-called small worldness. These phenomena appear to be correlated with cognitive functioning and with the occurrence of epileptic seizures in low-grade glioma patients. A better understanding of the relation between the presence of a glioma and the disruption of the neural network will in the future contribute to the planning of surgery and will make it possible to study neural plasticity.

Keywords

Low-grade glioma Functional connectivity Neural networks Epilepsy Cognitive functioning Magnetoencephalograpy 

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Jan J. Heimans
    • 1
    Email author
  • Jaap C. Reijneveld
    • 1
  • Cornelis J. Stam
    • 2
  1. 1.Department of NeurologyVU University Medical CenterAmsterdamThe Netherlands
  2. 2.Department of Clinical NeurophysiologyVU University Medical CenterAmsterdamThe Netherlands

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