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Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas

  • Hugues DuffauEmail author
Chapter

Abstract

Recent technical and conceptual advances in genetics, cognitive neurosciences, imaging, and treatments revolutionized the understanding of diffuse low-grade glioma, leading to the inhibition of dogmas and to the fundamental principle of personalized management.

Moreover, a better knowledge of brain processing enables now to take into consideration interaction between the disease (the glioma) and the host (the brain) and thus to modulate the dynamic therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life - that is, to move toward a “functional neurooncology”. In the era of “evidence-based medicine,” it is crucial to not forget “individual-based medicine.”

Keywords

Diffuse low-grade glioma Personalized management Individual-based medicine Functional neurooncology 

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Neurosurgery, Gui de Chauliac HospitalMontpellier University Medical CenterMontpellier Cedex 5France
  2. 2.National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Team “Brain Plasticity, Stem Cells and Glial Tumors”, Institute for Neurosciences of MontpellierMontpellier University Medical CenterMontpellierFrance

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