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Leiomyosarcoma

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Mohs Micrographic Surgery

Abstract

Leiomyosarcoma (LMS) is an uncommon soft tissue malignancy that may arise in the skin or subcutis. LMS occurs most frequently on the head and neck followed by the trunk, arms, and legs. LMS is a spindle cell neoplasm with an infiltrative growth pattern that stains positively with immunohistochemistry for vimentin, desmin, smooth muscle actin, and H-caldesmon. LMS is characterized by a high local recurrence rate with conventional wide excision (up to 45%). While metastasis has been reported in up to 30% of subcutaneous tumors, the metastatic potential of superficial cutaneous tumors is thought to be minimal. The overall cure rate of LMS treated by Mohs micrographic surgery is 87% which compares favorably to wide excision and offers the advantage of tissue sparing.

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Authors and Affiliations

  1. Department of Dermatology, Thomas Jefferson University, Philadelphia, PA, USA

    Marc Rubenzik, Boonyapat Limthongkul & Tatyana R. Humphreys

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  1. Marc Rubenzik
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  2. Boonyapat Limthongkul
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  3. Tatyana R. Humphreys
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Correspondence to Tatyana R. Humphreys .

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Editors and Affiliations

  1. Miller School of Medicine, Dept. Dermatology, University of Miami, NW. 10th Ave. 1600, Miami, 33136, Florida, USA

    Keyvan Nouri

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© 2012 Springer-Verlag London Limited

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Rubenzik, M., Limthongkul, B., Humphreys, T.R. (2012). Leiomyosarcoma. In: Nouri, K. (eds) Mohs Micrographic Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-2152-7_23

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  • DOI: https://doi.org/10.1007/978-1-4471-2152-7_23

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2151-0

  • Online ISBN: 978-1-4471-2152-7

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