Abstract
Recent physiological experiments have proved that a neuronal dendritic tree in the central nervous system (CNS) possesses the complex spatio-temporal dynamics. The dynamical properties of dendrite are expected to play an important role for the information processing in CNS. From this point of view, we construct a compartment model of an active dendrite in a discrete form in order to investigate its functional significance. The dynamics of the single compartment model is controlled mainly by the following two kinetic variables. One is the membrane potential which involves the several types of currents: T-type Ca 2+, L-type Ca 2+, and Ca2+-activated K +. The other is the intracellular Ca 2+ concentration that is increased by Ca 2+ influx and reduced by the cellular homeostatic system. The single compartment model responds in an oscillatory manner when a maintained current stimulation is applied. Figure 1 shows the relationship between the response firing frequency and the current intensity. There is the threshold and the optimal intensity of stimulus for the oscillatory response.
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© 1993 Springer-Verlag London Limited
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Katayama, N., Nakao, M., Mizutani, Y., Yamamoto, M. (1993). Simulation Study on Calcium-Activated Dynamics of Compartment Dendrite Model. In: Gielen, S., Kappen, B. (eds) ICANN ’93. ICANN 1993. Springer, London. https://doi.org/10.1007/978-1-4471-2063-6_46
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DOI: https://doi.org/10.1007/978-1-4471-2063-6_46
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Online ISBN: 978-1-4471-2063-6
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