Infertility pp 263-278 | Cite as

Extracorporeal Development of Immature Ovarian Follicles

  • R. G. Gosden
  • N. I. Boland

Abstract

The number of oocytes stored in the ovarian cortex at the beginning of reproductive life greatly exceeds that required for a lifetime of ovulatory cycles. It is, however, the number of mature cells rather than the much more abundant primordial and growing oocytes that is important for all practical purposes, such as treatment of infertility, animal production technology and investigative work. The oocytes available generally fall far short of needs.

Keywords

Permeability Toxicity Carbohydrate Adenosine Germinal 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Blandau RJ, Warrick E, Rumery RE. In vitro cultivation of fetal mouse ovaries. Fertil Steril 1965; 16: 705–15.PubMedGoogle Scholar
  2. 2.
    Blandau RJ, Odor DL. Observations on the behaviour of oogonia and oocytes in tissue and organ culture. In: Biggers JD, Schuetz AW, eds. Oogenesis. Baltimore: University Park Press, 1972; 301–20.Google Scholar
  3. 3.
    Baker TG, Neal P. Oogenesis in human fetal ovaries maintained in organ culture. J Anat 1974; 117: 591–604.PubMedGoogle Scholar
  4. 4.
    Freshney RI. Culture of animal cells–a manual of basic technique. New York: AR Liss, 1983; 225–8.Google Scholar
  5. 5.
    Wolff EK, Zondek B. Die Kultur menschlichen Ovarial-and Amniongewebes. Virchows Arch [A] 1925; 254: 1–16.Google Scholar
  6. 6.
    Martinovitch PN. The development in vitro of the mammalian gonad–ovary and ovogenesis Proc R Soc Lond B 1938; 125: 232–49.Google Scholar
  7. 7.
    Baker TG, Neal P. Gonadotrophin-induced maturation of mouse Graafian follicles in organ culture. In: Biggers JD, Schuetz AW, eds. Oogenesis. Baltimore: University Park Press, 1972; 377–96.Google Scholar
  8. 8.
    Ryle M. Morphological responses to pituitary gonadotrophins by mouse ovaries in vitro. J Reprod Fertil 1969; 20: 307–12.PubMedCrossRefGoogle Scholar
  9. 9.
    Lambertsen CJ, Greenbaum DF, Wright KH, Wallach EE. In vitro studies of ovulation in the perfused rabbit ovary. Fertil Steril 1976; 27: 178–87.PubMedGoogle Scholar
  10. 10.
    Gosden RG, Byatt-Smith JG. Oxygen concentration gradient across the ovarian follicular epithelium: models, predictions and implications. Hum Reprod 1986; 1: 65–8.PubMedGoogle Scholar
  11. 11.
    Moor RM, Hay MF, McIntosh JEA, Caldwell BV. Effect of gonadotrophins on the production of steroids by sheep ovarian follicles cultured in vitro. J Endocrinol 1973; 58: 599–611.PubMedCrossRefGoogle Scholar
  12. 12.
    Baker TG, Neal P. Organ culture of cortical fragments and Graafian follicles from human ovaries. J Anat 1974; 117: 361–71.PubMedGoogle Scholar
  13. 13.
    Baker TG, Hunter RHF, Neal P. Studies on the maintenance of porcine Graafian follicles in organ culture. Experientia 1975; 31: 133–5.PubMedCrossRefGoogle Scholar
  14. 14.
    Qvist R, Blackwell LF, Bourne H, Brown JB. Development of mouse ovarian follicles from primary to preovulatory stages in vitro. J Reprod Fertil 1990; 89: 169–80.PubMedCrossRefGoogle Scholar
  15. 15.
    Nayudu PL, Osborn SM. In vitro studies of factors influencing the rate of preantral and antral growth of isolated mouse ovarian follicles. J Reprod Fertil 1992 (in press).Google Scholar
  16. 16.
    Boland NI, Humpherson PG, Leese HJ, Gosden RG. Carbohydrate metabolism by mouse ovarian follicles. J Reprod Fertil (Abstr Ser) 1991; 8: 8.Google Scholar
  17. 17.
    Gosden RG, Hunter RHF, Telfer E, Torrance C, Brown JB. Physiological factors underlying the formation of ovarian follicular fluid. J Reprod Fertil 1988; 82: 813–25.PubMedCrossRefGoogle Scholar
  18. 18.
    Hillier SG. Sex steroid metabolism and follicular development in the ovary. Oxford Rev Reprod Biol 1985; 7: 168–222.Google Scholar
  19. 19.
    Spears N, Boland N, Murray A, Gosden R. Thecal colonization of mouse ovarian follicles. J Reprod Fertil (Abstr Ser) 1991; 7: 55.Google Scholar
  20. 20.
    Eppig JJ. Mouse oocyte development in vitro with various culture systems. Dev Biol 1977; 60: 371–88.PubMedCrossRefGoogle Scholar
  21. 21.
    Torrance C, Telfer E, Gosden RG. Quantitative study of the development of isolated mouse pre-antral follicles in collagen gel culture. J Reprod Fertil 1989; 87: 367–74.PubMedCrossRefGoogle Scholar
  22. 22.
    Telfer E, Torrance C, Gosden RG. Morphological study of cultured preantral ovarian follicles of mice after transplantation under the kidney capsule. J Reprod Fertil 1990; 89: 565–71.PubMedCrossRefGoogle Scholar
  23. 23.
    Carroll J, Whittingham DG, Wood MJ, Telfer E, Gosden RG. Extraovarian production of mature viable mouse oocytes from frozen primary follicles. J Reprod Fertil 1990; 90: 321–7.PubMedCrossRefGoogle Scholar
  24. 24.
    Eppig JJ, Schroeder AC. Capacity of mouse oocytes from preantral follicles to undergo embryogenesis and development to live young after growth, maturation and fertilization in vitro. Biol Reprod 1989; 41: 268–76.PubMedCrossRefGoogle Scholar
  25. 25.
    Daniel SAJ, Armstrong DT, Gore-Langton RE. Growth and development of rat oocytes in vitro. Gamete Res 1989; 24: 109–21.PubMedCrossRefGoogle Scholar
  26. 26.
    Eppig JJ, Schroeder AC, van de Sandt JJM, Ziomek CA, Bavister BD. Developmental capacity of mouse oocytes that grow and mature in culture: the effect of modification of the protocol. Theriogenology 1990; 33: 89–100.CrossRefGoogle Scholar
  27. 27.
    Eppig JJ. Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed in vitro from preantral follicles. Biol Reprod 1991; 45: 824–30.PubMedCrossRefGoogle Scholar
  28. 28.
    Bachvarova R, Baran MM, Tejblum A. Development of naked growing mouse oocytes in vitro. J Exp Zool 1980; 211: 159–69.PubMedCrossRefGoogle Scholar
  29. 29.
    Canipari R, Palombi F, Riminucci M, Mangia F. Early programming of maturation competence in mouse oogenesis. Dev Biol 1984; 102: 519–24.PubMedCrossRefGoogle Scholar
  30. 30.
    Moor RM, Smith MW, Dawson RMC. Measurement of intercellular coupling between oocytes and cumulus cells using intracellular markers. Exp Cell Res 1980; 126: 15–29.PubMedCrossRefGoogle Scholar
  31. 31.
    Hefner DT, Schultz RM. Ribonucleoside metabolism by mouse oocytes: metabolic cooperativity between the fully grown oocyte and cumulus cells. J Exp Zool 1980; 214: 355–64.CrossRefGoogle Scholar
  32. 32.
    Herlands RL, Schultz RM. Regulation of mouse oocyte growth: probable nutritional role for intercellular communication between follicle cells and oocytes in oocyte growth. J Exp Zool 1984; 229: 317–25.PubMedCrossRefGoogle Scholar
  33. 33.
    Wassarman P. The mammalian ovum. In: Knobil E, Neill J, eds. The physiology of reproduction. New York: Raven Press, 1988; 69–102.Google Scholar
  34. 34.
    Biggers JD, Whittingham DG, Donahue RP. The pattern of energy metabolism in the mouse oocyte and zygote. Proc Natl Acad Sci USA 1967; 58: 560–7.PubMedCrossRefGoogle Scholar
  35. 35.
    Bouquet M, Selva J, Auroux M. The incidence of chromosomal abnormalities in frozen-thawed mouse oocytes after in vitro fertilization. Hum Reprod 1992; 7: 76–80.PubMedGoogle Scholar
  36. 36.
    Sirard MA, Parrish JJ, Ware CB, Leibfried-Rutledge ML, First NL. The culture of bovine oocytes to obtain developmentally competent embryos. Biol Reprod 1988; 39: 546–52.PubMedCrossRefGoogle Scholar
  37. 37.
    Cha KY, Koo JJ, Ko JJ, Choi DH, Han SY, Yoon TK. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril 1991; 55: 109–13.PubMedGoogle Scholar
  38. 38.
    Johnston LA, Donoghue AM, O’Brien SJ, Wildt DE. Rescue and maturation in vitro of follicular oocytes collected from nondomestic fetid species. Biol Reprod 1991; 45: 898–906.PubMedCrossRefGoogle Scholar
  39. 39.
    Eppig JJ. Intercommunication between mammalian oocytes and companion somatic cells. BioEssays 1991; 13: 572.CrossRefGoogle Scholar

Copyright information

© Royal College of Obstetricians and Gynaecologists 1992

Authors and Affiliations

  • R. G. Gosden
  • N. I. Boland

There are no affiliations available

Personalised recommendations