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HIV-Related Dementia: Pathology and Possible Pathogenesis

  • Chapter
The Neuropathology of HIV Infection

Abstract

Soon after HIV-1 was identified as the cause of AIDS, the notion that some neurological disorders described in these patients (Johnson et al, 1988; Michaels et al, 1988a; Price et al, 1988a) could be due to the neurotropism of the virus (Shaw et al, 1985; Price et al, 1988a) became widely accepted. However, viral neurotropism is a concept encompassing the ability to invade and cause disease of the nervous system, as well as the capacity to replicate in neuroectodermal cells (Johnson et al, 1988). With regard to the in vivo situation of HIV infection, the third criterion still awaits confirmation as discussed in detail below.

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  1. H. Budka
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Editors and Affiliations

  1. Institute of Neurology, The National Hospital, Queen Square, WC1N 3BG, London, UK

    Francesco Scaravilli MD, PhD, FRCPath (Reader in Neuropathology) (Reader in Neuropathology)

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Budka, H. (1993). HIV-Related Dementia: Pathology and Possible Pathogenesis. In: Scaravilli, F. (eds) The Neuropathology of HIV Infection. Springer, London. https://doi.org/10.1007/978-1-4471-1957-9_7

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  • DOI: https://doi.org/10.1007/978-1-4471-1957-9_7

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