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Overview of HIV in the Nervous System

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The Neuropathology of HIV Infection
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Abstract

My intention in this chapter is to summarize some of the salient features of HIV in the nervous system, and in particular to highlight important areas of uncertainty which require further investigation. Although precise figures for nervous system involvement in HIV infection are not available, nevertheless it is abundantly clear that neurologists are seeing an increasing number of HIV-related neurological conditions as the number of individuals infected with HIV steadily increases. The pace of this increase is difficult to predict, but it is a sobering thought that the actual worldwide total of AIDS cases may well be in the region of 500000. At the end of December 1990 there were 4098 cases of AIDS in the UK, with 2256 deaths (Latest AIDS figures, 1990). Statistical predictions suggest that there will be 279000 cases of AIDS with 179 000 deaths in the USA by 1991, but the long-term effects of changes in sexual practices on statistical predictions remain to be seen.

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References

  • Anonymous. (1990) Zidovudine for symptomless HIV infection. Lancet 335:821–2.

    Article  Google Scholar 

  • Berger JR, Kaszovitz B, Post JD et al. (1987) Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection: a review of the literature with a report of sixteen cases. Ann Intern Med 107:78–87.

    PubMed  CAS  Google Scholar 

  • Budka H, Costanzi G, Cristina S et al. (1987) Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol 75: 185–98.

    Article  PubMed  CAS  Google Scholar 

  • Dalgleish AG, Beverley PCL, Clapham PR et al. (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763–7.

    Article  PubMed  CAS  Google Scholar 

  • De Clecq E. (1990) Targets and strategies for the antiviral Overview of HIV in the Nervous System chemotherapy of AIDS. TiPS 1990; 11:198–205.

    Google Scholar 

  • Eilbott DJ, Peress N, Burger H et al. (1989) Human immunodeficiency virus Type I in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. Proc Natl Acad Sci USA 86:3337–41.

    Article  PubMed  CAS  Google Scholar 

  • Epstein LG, Sharer LR. (1988) Neurology of human immunodeficiency virus infection in children. In: Rosenblum ML, Levy RM, Bredesen DE, ed. AIDS and the nervous system. Raven Press: New York, 79–101.

    Google Scholar 

  • Epstein LG, Sharer LR, Oleske JM et al. (1986) Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics 78:678–87.

    PubMed  CAS  Google Scholar 

  • Funke I, Hahn A, Rieber EP et al. (1987) The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain. J Exp Med 165:1230–5.

    Article  PubMed  CAS  Google Scholar 

  • Gendelman HE, Narayan O, Molineaux S et al. (1985) Slow persistent replication of lentiviruses: role of macrophages and macrophage-precursors in bone marrow. Proc Natl Acad Sci USA 82:7086–90.

    Article  PubMed  CAS  Google Scholar 

  • Gendelman HE, Leonard JM, Dutko FJ et al. (1988) Immunopathogenesis of human immunodeficiency virus infection in the central nervous system. Ann Neurol 23 (suppl):s78–81.

    Article  PubMed  Google Scholar 

  • Gonda MA, Brown MJ, Clements JE et al. (1985) Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science 227: 173–7.

    Article  PubMed  CAS  Google Scholar 

  • Gray F, Gherardi R, Scaravilli F. (1988) The neuropathology of the acquired immune deficiency syndrome (AIDS). Brain 111:245–66.

    Article  PubMed  Google Scholar 

  • Ho D, Rota T, Schooley R, et al (1985) Isolation of HTLVIII from cerebrospinal fluid and neural tissues of patients with neurological syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 313:1493–503.

    Article  PubMed  CAS  Google Scholar 

  • Hosie MJ, Robertson C, Jarrett O. (1989) Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Vet Rec 128:293–7.

    Article  Google Scholar 

  • Kennedy PGE. (1988a) Human immunodeficiency virus infections of the nervous system. Curr Opin Neurol Neurosurg 1:147–52.

    Google Scholar 

  • Kennedy PGE. (1988b) Neurological complications of human immunodeficiency virus infection. Postgrad Med J 164:180–7.

    Article  Google Scholar 

  • Kennedy PGE. (1989) Human immunodeficiency virus infection of the nervous system. Curr Opin Neurol Neurosurg 2:191–4.

    Google Scholar 

  • Lane MC, Masur H, Edgar LC et al (1983) Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 309: 453–8.

    Article  PubMed  CAS  Google Scholar 

  • Lantos PL, McLaughlin JE, Scholtz CL et al. (1989) Neuropathology of the brain in HIV infection. Lancet i:309–11. Latest AIDS Figures. (1990) Lancet 335:119.

    Google Scholar 

  • Letvin NL, Daniel MD, Sehgal PK et al. (1986) Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 230:71–3.

    Article  Google Scholar 

  • Levy RM, Bredesen DE, Rosenblum ML. (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and a review of the literature. J Neurosurg 62:475–95.

    Article  PubMed  CAS  Google Scholar 

  • Maier H, Budka H, Lassmann H et al. (1989) Vacuolar myelopathy with multinucleate giant cells in the acquired immunodeficiency syndrome (AIDS). Light and electron microscopic distribution of human immunodeficiency virus (HIV) antigens. Acta Neuropathol 78:497–503.

    Article  PubMed  CAS  Google Scholar 

  • McArthur JC. (1987) Neurologic complications of AIDS. Medicine (Baltimore) 66:407–37.

    CAS  Google Scholar 

  • McDonald WI, Weber J. (1989) Meeting report HIV and the nervous system. MRC-INSERM 19–20 January 1989, Paris, France. AIDS 3:465–7.

    Google Scholar 

  • Monte de la SM, Ho DD, Schooley RT, et al. (1987) Subacute encephalomyelitis of AIDS and its relation to HTLV-Ill infection. Neurology 37:562–9.

    PubMed  Google Scholar 

  • Navia BA, Price RW. (1987) The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immuI10deficiency virus infection. Arch Neuro 144:65–9.

    Article  Google Scholar 

  • Navia BA, Jordan BD, Price RW. (1986a) The AIDS dementia complex: 1. Clinical features. Ann Neurol 19: 517–24.

    Article  PubMed  CAS  Google Scholar 

  • Navia BA, Cho E-S, Petito CK et al. (1986b) The AIDS dementia complex: 2. Neuropathology. Ann Neurol 19: 525–35.

    Google Scholar 

  • Nelson JA, Reynolds-Kohler C, Oldstone MBA et al. (1988) HIV and HCMV coinfect brain cells in patients with AIDS. Virology 165:286–90.

    Article  PubMed  CAS  Google Scholar 

  • Petito CK, Navia BA, Cho E-S et al. (1985) Vacuolar myelopathy pathologically resembling Sllbacute combined degeneration in patients with the Acquired Immunodeficiency Syndrome. N Engl J Med 312:874–9.

    Article  PubMed  CAS  Google Scholar 

  • Petito CK, Cho E-S, Lemann W et al. (1986) Neuropathology of acquired immunodeficiency syndrome (AIDS): an autopsy review. J Neuropathol Exp Neurol 45:635–46.

    Article  PubMed  CAS  Google Scholar 

  • Portegies P, de Gans J, Lange JMA et al. (1989) Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. Br Med J 299:819–21.

    Article  CAS  Google Scholar 

  • Price RW, Navia BA. (1987) Infections in AIDS and in other immunosuppressed patients. In: Kennedy PGE, Johnson RT, ed. Infections of the nervous system. Butterworths: Sevenoaks 248–73.

    Google Scholar 

  • Price RW, Brew B, Sidtis J et al. (1988a) The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239:586–91.

    Article  PubMed  CAS  Google Scholar 

  • Price RW, Sidtis J, Rosenblum M. (1988b) The AIDS dementia complex: some current questions. Ann Neurol 23 (suppl):s27–33.

    Article  PubMed  Google Scholar 

  • Resnick L, Berger JR, Shapshak P et al (1988) Early penetration of the blood-brain-barrier by HIV. Neurology 38:9–14.

    PubMed  CAS  Google Scholar 

  • Shaw GM, Harper ME, Hahn BH et al. (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science 227:177–82.

    Article  PubMed  CAS  Google Scholar 

  • Snider WD, Simpson DM, Nielsen S et al. (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol 14:403–18.

    Article  PubMed  CAS  Google Scholar 

  • Sonnerborg AB, Ehrnst AC, Bergdahl SKM et al. (1988) HIV isolation from cerebrospinal fluid in relation to immunological deficiency and neurological symptoms. AIDS 2: 89–94.

    Article  PubMed  CAS  Google Scholar 

  • Surtees R, Hyland K, Smith I. (1990) Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection. Lancet 335:619–21.

    Article  PubMed  CAS  Google Scholar 

  • Tross S, Price RW, Navia B et al. (1988) Neuropsychological characterization of the AIDS dementia complex: a preliminary report. AIDS 2:81–8.

    Article  PubMed  CAS  Google Scholar 

  • Wiley CA, Schrier RD, Nelson JA et al. (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 83:7089–93.

    Article  PubMed  CAS  Google Scholar 

  • Yarchoan R, Thomas RV, Graffman J et al. (1988) Long-term administration of 3’-azido-2’, 3’-dideoxythymidine to patients with AIDS-related neurological disease. Ann Neuro l23 (suppl):s82–7.

    Article  Google Scholar 

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© 1993 Springer-Verlag London Limited

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Kennedy, P.G.E. (1993). Overview of HIV in the Nervous System. In: Scaravilli, F. (eds) The Neuropathology of HIV Infection. Springer, London. https://doi.org/10.1007/978-1-4471-1957-9_13

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  • DOI: https://doi.org/10.1007/978-1-4471-1957-9_13

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1959-3

  • Online ISBN: 978-1-4471-1957-9

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