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Peripheral Nerve and Muscle Disease in HIV Infection

  • Chapter
The Neuropathology of HIV Infection

Abstract

Peripheral neuropathies were among the first neurological conditions to be described in AIDS (Snider et al, 1983). In the intervening 8 years, much has been learned of the pathogenesis of AIDS and many of its neurological complications. The demonstration of the direct involvement of HIV in central nervous system (CNS) conditions (discussed in Chapters 6 and 7) has led many workers to seek a similar role for HIV in the peripheral nervous system (PNS). No conclusive evidence has yet been found for this. The neuropathology of AIDS in the PNS is less well documented than in the CNS, and peripheral nerve syndromes are frequently without neuropathological correlates.

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References

  • Bailey RO, Turok DI, Jaufmann BP et al. (1987) Myositis and acquired immunodeficiency syndrome. Hum Pathol 18:749–51.

    Article  PubMed  CAS  Google Scholar 

  • Bailey RO, Baltch AL, Venkatesh R et al. (1988) Sensory motor neuropathy associated with AIDS. Neurology 38:886–91.

    PubMed  CAS  Google Scholar 

  • Behar R, Wiley C, McCutchan JA. (1981) Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome. Neurology 37:557–61.

    Google Scholar 

  • Bélec L, Gherardi R, Georges AJ et al. (1989) Peripheral facial paralysis and HIV infection: report of four African cases and review of the literature. J Neurol 236:411–14.

    Article  PubMed  Google Scholar 

  • Beral V, Peterman T, Berkelman R. (1989) Epidemiology of AIDS-associated lymphomas: United States. In: Fifth International Conference on AIDS, Montreal, Canada (1989), Abstract WAP 17, IDRC: Ottowa, p. 17.

    Google Scholar 

  • Bessen LJ, Greene JB, Louie E et al. (1988) Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC. N Engl J Med 318:708.

    PubMed  CAS  Google Scholar 

  • Bishopric G, Bruner J, Butler J et al. (1985) Guillain-Barre syndrome with cytomegalovirus infection of peripheral nerves. Arch Pathol Lab Med 109:1106–8.

    PubMed  CAS  Google Scholar 

  • Brown MM, Thompson A, Goh BT et al. (1988) Bell’s palsy and HIV infection. J Neurol Neurosurg Psychiatry 51:425–6.

    Article  PubMed  CAS  Google Scholar 

  • Cabello A, Martinez-Martin P, Guierrez-Rivas E et al. (1990) Myopathy with nemaline structures associated with HIV infection. J Neurol 237:64–8.

    Article  PubMed  CAS  Google Scholar 

  • Calabrese LH, Proffitt MR, Levin Yen-Lieberman B et al. (1987) Acute infection with the human immunodeficiency virus (HIV) associated with acute brachial neuritis and erythematous rash. Ann Intern Med 107:849–51.

    PubMed  CAS  Google Scholar 

  • Campbell MJ, Paty DW. (1974) Carcinomatous neuromyopathy: 1. Electrophysiological studies. J Neurol Neurosurg Psychiatry 37:131–41.

    Article  PubMed  CAS  Google Scholar 

  • Carne CA, Stibe C, Brokenhurst A et al. (1989) Subclinical neurological and neuropsychological effect of infection with HIV. Genitourin Med 65:151–6.

    PubMed  CAS  Google Scholar 

  • Centers for Disease Control. (1986) CDC classification system for human T-Iymphotropic virus type III/lymphadenopathyassociated virus infections. MMWR 35:334–9.

    Google Scholar 

  • Chaunu MP, Ratinahirana H, Raphael M et al. (1989) The spectrum of changes on 20 nerve biopsies in patients with HIV infection. Muscle Nerve 12:452–9.

    Article  PubMed  CAS  Google Scholar 

  • Cooper DA, Gold J, Maclean P. (1985) Acute AIDS retrovirus infection. Definition of a clinical illness associated with seroconversion. Lancet i:537–40.

    Article  Google Scholar 

  • Cornblath DR, McArthur JC. (1988) Predominantly sensory neuropathy in patients with AIDS and AIDS related complex. Neurology 38:794–6.

    PubMed  CAS  Google Scholar 

  • Cornblath DR, McArthur JC, Kennedy PGE. (1987) Inflammatory demyelinating peripheral neuropathies associated with human T-cell lymphotropic virus type III infection. Ann Neurol 21:32–40.

    Article  PubMed  CAS  Google Scholar 

  • Craddock C, Pasrol G, Bull R et al. (1987) Cardiorespiratory arrest and autonomic neuropathy in AIDS. Lancet 2: 16–18.

    Article  PubMed  CAS  Google Scholar 

  • Dahan P, Haettich B, Le Parc JM. (1988) Meningoradiculitis due to herpes simplex virus disclosing HIV infection. Ann Rheum Dis 47:440.

    Article  PubMed  CAS  Google Scholar 

  • Dalakas MC, Pezeshkpour GH. (1988) Neuromuscular diseases associated with human immunodeficiency virus infection. Ann Neurol 23 (suppl):s38–48.

    Article  PubMed  Google Scholar 

  • Dalakas MC, Pezeshkpour GH, Gravell M et al. (1986) Polymyositis associated with AIDS retrovirus. JAMA 256:2381–3.

    Article  PubMed  CAS  Google Scholar 

  • Dalakas MC, Wichman A, Sever JL. (1989) AIDS and the nervous system. JAMA 261:2396–2399.

    Article  PubMed  CAS  Google Scholar 

  • Dalakas MC, Ilia I, Pezeshkpour GH et al. (1990) Mitochondrial myopathy caused by long-term zidovudine therapy. N Engl J Med 322: 1095–1105.

    Article  Google Scholar 

  • Dubinsky RM, Yarchoan R, Dalakas M et al. (1989) Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2’3’-dideoxycytidine (ddC). Muscle Nerve 12:856–60.

    Article  PubMed  CAS  Google Scholar 

  • Eldelberg D, Sotrel A, Vogel H et al. (1986) Progressive polyradiculopathy in acquired immune deficiency syndrome. Neurology 36:912–16.

    Google Scholar 

  • Engel WK, Resnick JS. (1966) Late-onset rod myopathy: a newly recognised, acquired and progressive disease. Neurology 16:308–9.

    Google Scholar 

  • Freeman MS, Friedman LS, Broadbridge C. (1990) Autonomic function in human immunodeficiency virus infection. Neurology 40:575–80.

    PubMed  CAS  Google Scholar 

  • Fuller GN, Jacobs JM. (1989) Cytomembranous inclusions in the peripheral nerve in AIDS. Acta Neuropathol (Berl) 79:336–9.

    Article  CAS  Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1989) Association of painful peripheral neuropathy in AIDS with cytomegalovirus infection. Lancet ii:937–41.

    Article  Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1990a) Incidence and classification of peripheral nerve syndromes in HIV infection. A prospective study. J Neurol Neurosurg Psychiatry 54:751.

    Google Scholar 

  • Fuller GN, Greco C, Miller RG. (1990b) Cytomegalovirus and mononeuropathy multiplex in AIDS. Neurology 40 (suppl 1):301.

    Google Scholar 

  • Fuller GN, Gill SK, Guiloff RJ et al. (1990c) Ganciclovir for lumbosacral polyradiculopathy in AIDS. Lancet i:48–9.

    Article  Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1990d) Axonal atrophy in the painful neuropathy in AIDS. Acta Neuropathol (Berl) 81: 198–203.

    Article  CAS  Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1990e) Non-painful distal symmetrical peripheral neuropathies in AIDS. J Neurol Neurosurg Psychiatry 54:755.

    Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1991a) Subclinical peripheral nerve involvement in AIDS: an electrophysiological and pathological study. J Neurol Neurosurg Psychiatry 54:318–24.

    Article  PubMed  CAS  Google Scholar 

  • Fuller GN, Jacobs JM, Guiloff RJ. (1991b) Thalidomide, peripheral neuropathy and AIDS. Int J STD AIDS 2:369–370.

    PubMed  CAS  Google Scholar 

  • Gastaut JA, Gastaut JL, Pellissier JF et al. (1987) Neuropathie périphérique et infection par Ie retrovirus HIV. Presse Méd 16:1057.

    PubMed  CAS  Google Scholar 

  • Gherardi R, Lebargy F, Gaulard P et al. (1989) Necrotizing vasculitis and HIV replication in peripheral nerves. N Engl J Med 321:685–6.

    PubMed  CAS  Google Scholar 

  • Gold JE, Jimenez E, Zalusky R. (1988) Human immunodeficiency virus-related Iymphoreticular malignancies and peripheral neurologic disease: a report of four cases. Cancer 61:2318–24.

    Article  PubMed  CAS  Google Scholar 

  • Gonzales MF, Olney RK, Yuen TS et al. (1988) Subacute The Neuropathology of HIV Infection structural myopathy associated with human immunodeficiency virus infection. Arch Neurol 45:585–7.

    Article  PubMed  CAS  Google Scholar 

  • Gorard DA, Henry K, Guiloff RJ. (1988) Necrotising myopathy and zidovudine. Lancet i:1050.

    Google Scholar 

  • Grafe MR, Wiley CA. (1989) Spinal cord and peripheral nerve pathology in AIDS: the roles of cytomegalovirus and human immunodeficiency virus. Ann Neurol 25:561–6.

    Article  PubMed  CAS  Google Scholar 

  • Guiloff RJ, Fuller GN, Roberts A et al. (1988) Nature, incidence and prognosis of neurological involvement in the acquired immunodeficiency syndrome in Central London. Postgrad Med J 64:919–25.

    Article  PubMed  CAS  Google Scholar 

  • Hagberg L, Malmvall B-E, Svennerholm L et al. (1986) Guillain-Barre syndrome as an early manifestation of HIV central nervous system infection. Scand J Infect Dis 18:591–2.

    Article  PubMed  CAS  Google Scholar 

  • Harriman GR, Smith PD, Horne MK. (1989) Vitamin B12 malabsorption in patients with acquired immunodeficiency syndrome. Arch Intern Med 149:2039–41.

    Article  PubMed  CAS  Google Scholar 

  • Ho DD, Sarngadharan MG, Resnick L et al. (1985a) Primary human T-Iymphotropic virus type III infection. Ann Intern Med 103:880–3.

    PubMed  CAS  Google Scholar 

  • Ho DD, Rota TR, Schooley RT et al (1985b) Isolation of HTLV-III from cerebrospinal fluid and neural tissue of patients with neurological syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 313: 1493–8.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman PM, Festoff BW, Giron LT et al. (1985) Isolation of LAV/HTLV-III from a patient with amyotrophic lateral sclerosis. N Engl J Med 313:324–5.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson MA, Mills J, Rush J et al. (1988) Failure of antiviral therapy for acquired immunodeficiency syndrome-related cytomegalovirus myelitis, Arch Neurol 45: 1090–2.

    Article  PubMed  CAS  Google Scholar 

  • Jeantils V, Lemaitre MO, Robert J et al. (1986) Subacute polyneuropathy with encephalopathy in AIDS with human cytomegalovirus pathogenicity. Lancet ii: 1039.

    Article  Google Scholar 

  • Jellinger K, Radiaszkiewicz T. (1976) Involvement of the central nervous system in malignant lymphomas. Virchows Arch[A] 370:345–62.

    CAS  Google Scholar 

  • Kinlen LJ, Sheil AGR, Peto J et al. (1979) Collaborative United Kingdom-Australian study of cancer in patients treated with immunosuppressive drugs. Br Med J 2: 1461–6.

    Article  PubMed  CAS  Google Scholar 

  • Lagueny A, Rommel A, Vignolly et al. (1986) Thalidomide neuropathy: an electrophysiologic study. Muscle Nerve 9:837–44.

    Article  PubMed  CAS  Google Scholar 

  • Lange DJ, Britton CB, Younger DS et al. (1988) The neuromuscular manifestations of human immunodeficiency virus infections. Arch Neural 45: 1084–8.

    Article  CAS  Google Scholar 

  • Lanska MJ, Lanska DJ, Schmidley JW. (1988) Syphilitic polyradiculopathy in an HIV-positive man. Neurology 38: 1297–1301.

    PubMed  CAS  Google Scholar 

  • Léger JM, Bouche P, Bolgert F et al. (1989) The spectrum of polyneuropathies in patients infected with HIV. J Neurol Neurosurg Psychiatry 52: 1369–74.

    Article  PubMed  Google Scholar 

  • Le Quesne PM. (1984) Neuropathy due to drugs. In: Dyck PJ, Thomas PK, Lambert EH et al, ed. Peripheral Neuropathy, 2nd edn. WB Saunders: Philadelphia, 2162–79.

    Google Scholar 

  • Lipkin WI, Parry G, Kiprov D et al. (1985) Inflammatory neuropathy in homosexual men with lymphadenopathy. Neurology 35: 1479–83.

    PubMed  CAS  Google Scholar 

  • Lohmoller G, Matuschke A, Goebel FD. (1987) Testing for neurological involvement in HIV infection. Lancet ii: 1532.

    Google Scholar 

  • Mah V, Vartavarian LM, Akers MA et al. (1988) Abnormalities of peripheral nerve in patients with human immunodeficiency virus infection. Ann Neurol 24:713–17.

    Article  PubMed  CAS  Google Scholar 

  • Mahieux F, Gray F, Fenelon G et al. (1989) Acute myeloradiculitis due to cytomegalovirus as the initial manifestation of AIDS. J Neurol Neurosurg Psychiatry 52:270–4.

    Article  PubMed  CAS  Google Scholar 

  • Marolda M, De Mercato R, Camporeale FS et al. (1989) Myopathy associated with AIDS. Ital J Neurol Sci 10:423–7.

    Article  PubMed  CAS  Google Scholar 

  • McArthur JC. (1987) Neurologic manifestations of AIDS. Medicine 66:407–37.

    Article  PubMed  CAS  Google Scholar 

  • Merigan TC, Skowron G, Bozzette SA et al. (1989) Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. Ann Intern Med 110: 189–94.

    PubMed  CAS  Google Scholar 

  • Miller RG, Parry GJ, Pfaeffl W et al. (1988) The spectrum of peripheral neuropathy associated with ARC and AIDS. Muscle Nerve 11:857–63.

    Article  PubMed  CAS  Google Scholar 

  • Miller RG, Storey RG, Greco C. (1989) Successful treatment of progressive polyradiculopathy in AIDS patients. Neurology 39 (suppl 1):271.

    Google Scholar 

  • Monte de la SM, Gabuzda DH, Ho DO et al. (1988) Peripheral neuropathy in the acquired immunodeficiency syndrome. Ann Neurol 23:485–92.

    Article  PubMed  Google Scholar 

  • Moskowitz LB, Gregorios JB, Hensley GT et al. (1984) CMV induced demyelination associated with AIDS. Arch Pathol Lab Med 108:873–7.

    PubMed  CAS  Google Scholar 

  • Novak IS, Trujillo JR, Rivera VM et al. (1989) Ganciclovir in the treatment of CMV infection in AIDS patients with neurologic complications. Neurology 39 (suppl 1):379–80.

    Google Scholar 

  • Panegyres PK, Papadimitriou JM, Hollingsworth JA et al. (1990) Vesicular change in the myopathies of AIDS. Ultrastructural observations and their relationship to zidovudine treatment. J Neurol Neurosurg Psychiatry 53:649–55.

    Article  PubMed  CAS  Google Scholar 

  • Parry GJ. (1988) Peripheral neuropathies associated with human immunodeficiency virus infection. Ann Neurol 23 (suppl):s49–53.

    Article  PubMed  Google Scholar 

  • Paul T, Katiyar BC, Misra S. (1978) Carcinomatous neuromuscular syndromes: a clinical and quantitative electrophysiological study. Brain 101:53–63.

    Article  PubMed  CAS  Google Scholar 

  • Pepose JS, Newman C, Bach MC et al. (1987) Pathologic features of cytomegalovirus retinopathy after treatment with the agent ganciclovir. Ophthalmology 94:414.

    PubMed  CAS  Google Scholar 

  • Piette AM, Tusseau F, Vignon D et al. (1986) Acute neuropathy coincident with seroconversion for anti-LAV/HTLV-III. Lancet i:852.

    Article  Google Scholar 

  • Rance NE, McArthur JC, Cornblath DR et al. (1988) Gracile tract degeneration in patients with sensory neuropathy in AIDS. Neurology 38:265–71.

    PubMed  CAS  Google Scholar 

  • Richman DO, Fischl MA, Grieco MH et al. (1987) The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A doubleblind, placebo-controlled trial. N Engl J Med 317: 192–7.

    Article  PubMed  CAS  Google Scholar 

  • Riggs JE, Rogers JS II, Schochet SS Jr et al. (1987) AIDS-related neuropathy. W V Med J 83:167–9.

    PubMed  CAS  Google Scholar 

  • Robert ME, Geraghty JJ, Miles SA et al. (1989) Severe neuropathy in a patient with acquired immune deficiency syndrome: evidence for widespread cytomegalovirus infection of peripheral nerve and human immunodeficiency virus-like immunoreactivity of anterior horn cells. Acta Neuropathol (Berl) 79:255–61.

    Article  CAS  Google Scholar 

  • Said G, Lacroix-Ciaudo C, Fujimura H et al. (1988) The peripheral neuropathy of necrotizing arteritis; a clinicopathological study. Ann Neurol 23:461–5.

    Article  PubMed  CAS  Google Scholar 

  • Simpson OM, Bender AN. (1988) Human immunodeficiency virus-associated myopathy: analysis of 11 cases. Ann Neurol 24:79–84.

    Article  PubMed  CAS  Google Scholar 

  • Singh BM, Levine S, Yarrish RL et al. (1986) Spinal cord syndromes in the acquired immune deficiency syndrome. Acta Neurol Scand 73:590–8.

    Article  PubMed  CAS  Google Scholar 

  • Small PM, McPhaul LW, Sooy CD et al. (1989) Cytomegalovirus infection of the laryngeal nerve presenting as hoarseness in patients with acquired immunodeficiency syndrome. Am J Med 86:108–10.

    Article  PubMed  CAS  Google Scholar 

  • Snider WD, Simpson OM, Nielsen S et al. (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol 14:403–18.

    Article  PubMed  CAS  Google Scholar 

  • So YT, Holtzman DM, Abrams DI et al. (1988) Peripheral neuropathy associated with acquired immunodeficiency syndrome: prevalence and clinical features from a population based survey. Arch Neurol 45:945–8.

    Article  PubMed  CAS  Google Scholar 

  • Sotaniemi KA. (1984) Slimmer’s paralysis — peroneal neuropathy during weight reduction. J Neurol Neurosurg Psychiatry 47:564–6.

    Article  PubMed  CAS  Google Scholar 

  • Stern R, Gold J, Dicarlo EF. (1987) Myopathy complicating the acquired immune deficiency syndrome. Muscle Nerve 10:318–22.

    Article  PubMed  CAS  Google Scholar 

  • Tucker T, Dix RD, Katzen C et al. (1985) Cytomegalovirus and herpes simplex virus ascending myelitis in a patient with acquired immune deficiency syndrome. Ann Neurol 18:74–9.

    Article  PubMed  CAS  Google Scholar 

  • Vinters HV, Kwok MK, Ho HW et al. (1989) Cytomegalovirus in the nervous system of patients with the acquired immune deficiency syndrome. Brain 112:245–68.

    Article  PubMed  Google Scholar 

  • Vishnubhakat SM, Beresford R. (1988) Prevalence of peripheral neuropathy in HIV disease: prospective study of 40 patients. Neurology 38 (suppl 1):350.

    Google Scholar 

  • Walsh JC. (1971) Neuropathy associated with lymphoma. J Neurol Neurosurg Psychiatry 34:42–50.

    Article  PubMed  CAS  Google Scholar 

  • Weber CA, Figueroa JP, Calabro JJ et al. (1987) Cooccurrence of the Reiter syndrome and acquired immunodeficiency. Arch Intern Med 107: 112–13.

    CAS  Google Scholar 

  • Winer JB, Hughes RAC, Anderson MJ et al. (1988) A prospective study of acute idiopathic neuropathy. II Antecedent events. J Neurol Neurosurg Psychiatry 51:613–18.

    Article  PubMed  CAS  Google Scholar 

  • Wiselka MJ, Nicholson KG, Ward SC et al. (1987) Acute infection with human immunodeficiency virus associated with facial nerve palsy and neuralgia. J Infect Dis 15: 189–94.

    CAS  Google Scholar 

  • Woolsey RM. (1989) Treatable causes of meningomyelitis in individuals infected with human immunodeficiency virus. Arch Neurol 46:723.

    Article  Google Scholar 

  • Zacks SI, Langfitt TW, Elliot FA. (1964) Herpetic neuritis: a light and electron microscopic study. Neurology 14:744–50.

    PubMed  CAS  Google Scholar 

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Authors
  1. G. N. Fuller
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  2. J. M. Jacobs
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Editors and Affiliations

  1. Institute of Neurology, The National Hospital, Queen Square, WC1N 3BG, London, UK

    Francesco Scaravilli MD, PhD, FRCPath (Reader in Neuropathology) (Reader in Neuropathology)

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Fuller, G.N., Jacobs, J.M. (1993). Peripheral Nerve and Muscle Disease in HIV Infection. In: Scaravilli, F. (eds) The Neuropathology of HIV Infection. Springer, London. https://doi.org/10.1007/978-1-4471-1957-9_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1957-9_10

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