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HIV Infection: A Cellular Approach

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The Neuropathology of HIV Infection

Abstract

The human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are RNA viruses which belong to the lentivirus group of the retrovirus family (Weiss, 1985). In common with other members of this group which infect animals (visna/maedi virus, equine infectious anaemia virus, caprine arthritis/encephalitis virus), HIV is a non-transforming virus (that is, not directly oncogenic) which replicates through the generation of a proviral DNA intermediate by the action of the retroviral enzyme RNA-directed DNA polymerase (reverse transcriptase, RT). HIV is a virus capable of causing lysis in infected cells. There is a visible cytopathic effect in vitro, which can be used for assays of HIV infectivity. In vivo, a persistent infection is established following integration of proviral DNA into the host genome. Infection lasts for the life of the cell, and after sufficient cells are infected, infection lasts for the life of the host. All retroviral infections appear to be persistent.

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References

  • Bangham CR, McMichael AJ. (1990) Virology: nosing ahead in the cold war. Nature 344: 16.

    Article  PubMed  CAS  Google Scholar 

  • Cheng-Mayer C, Rutka JT, Rosenblum ML et al. (1985) Human immunodeficiency virus can productively infect cultured human glial cells. Proc Natl Acad Sci USA 84: 3526–30.

    Article  Google Scholar 

  • Dalgliesh AG, Beverley PCL, Clapham PR et al. (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:767–8.

    Article  Google Scholar 

  • Daniel MD, Letvin NL, King NW et al. (1985) Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201–4.

    Article  PubMed  CAS  Google Scholar 

  • Daniel MD, Li Y, Naidu YM et al. (1988) Simian immunodeficiency virus from African green monkeys. J Virol 62:4123–8.

    PubMed  CAS  Google Scholar 

  • Debouck C, Gorniak JG, Strickler JE et al. (1987) Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor. Proc Natl Acad Sci USA 84:8903–6.

    Article  PubMed  CAS  Google Scholar 

  • Desrosiers RC. (1988) Simian immunodeficiency viruses. Annu Rev Microbiol 42:607–25.

    Article  PubMed  CAS  Google Scholar 

  • Evans LA, Levy JA. (1989) Characteristics of HIV infection and pathogenesis. Biochim Biophys Acta 989:237–54.

    PubMed  CAS  Google Scholar 

  • Fukasawa M, Miura T, Hasegawa A et al. (1988) Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group. Nature 333:457–61.

    Article  PubMed  CAS  Google Scholar 

  • Gardner MB, Luciw PA. (1988) Simian immunodeficiency viruses and their relationship to the human immunodeficiency viruses. AIDS 2 (suppl 1):s3–10.

    Article  PubMed  Google Scholar 

  • Gelderblom HR, Hausmann EH, Ozel M et al. (1987) Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 156: 171–6.

    Article  PubMed  CAS  Google Scholar 

  • Guy B, Kieny MP, Riviere Y et al. (1987) Nature 330:266–9.

    Article  PubMed  CAS  Google Scholar 

  • Haseltine WA, Wong-Staal F. (1988) The molecular biology of the AIDS virus. Sci Am 259:52–62.

    Article  PubMed  CAS  Google Scholar 

  • Hauber J, Perkins A, Heimer EP et al. (1987) Transactivation of human immunodeficiency virus gene expression is mediated by nuclear events. Proc Natl Acad Sci USA 84:6364–8.

    Article  PubMed  CAS  Google Scholar 

  • Kestler H, Kodama T, Ringer D et al. (1990) Induction of AIDS in rhesus macaques by molecularly cloned SIV. Science 248: 1109–128

    Article  PubMed  CAS  Google Scholar 

  • Klatzmann D, Champagne E, Chamaret S et atl. (1984a) Tlymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312:767–8.

    Article  CAS  Google Scholar 

  • Klatzmann O, Champagne E, Chamaret S et at. (1984b) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 225:59–63.

    CAS  Google Scholar 

  • Luciw PA, ChengMayer C, Levy JA. (1987) Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication. Proc Natl Acad Sci USA 84:1434–8

    Article  PubMed  CAS  Google Scholar 

  • Maddon PJ, Dalgleish AG, McDougal JS et at. (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333–48.

    Article  PubMed  CAS  Google Scholar 

  • Mulder C. (1988) Human AIDS virus is not from monkeys. Nature 333:396.

    Article  PubMed  CAS  Google Scholar 

  • Nabei G, Baltimore D. (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T-cells. Nature 326:711–13.

    Article  Google Scholar 

  • O’Brien WA, Koyanagi Y, Namazie A et at. (1990) HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp…120 outside the CD4-binding domain. Nature 348:69–73.

    Article  PubMed  Google Scholar 

  • Pang S, Koyanagi Y, Miles S et at. (1990) High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients. Nature 343:85–9.

    Article  PubMed  CAS  Google Scholar 

  • Peeters M, Honore C, Huet T et at. (1989) Isolation and partial characteriz;ation of an HIV related virus occurring naturally in chimpanzees in Gabon. AIDS 3:625–31.

    Article  PubMed  CAS  Google Scholar 

  • Peterlin BM, Luciw PA. (1988) Molecular biology of HIV. AIDS 2 (suppl 1): 829–40.

    Google Scholar 

  • Rosenburg Z, Fauci A. (1990) Cytokine induction of HIV expression. Immunol Today 11:176.

    Article  Google Scholar 

  • Saag MS, Hahn BH, Gibbons J et at. (1988) Extensive The Neuropathology of HIV Infection variation of human immunodeficiency virus type-1 in vivo. Nature 334:440–4.

    Article  PubMed  CAS  Google Scholar 

  • Schneider J, Hunsmann G. (1988) Simian lentiviruses: the SIV group. AIDS 2:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Sodroski J, Rosen C, Wong-Staal F et at. (1985) Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 227: 171–3.

    Article  PubMed  CAS  Google Scholar 

  • Sodroski J, Goh WC, Rosen C et at. (1986) Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Science 231: 1549–53.

    Article  PubMed  CAS  Google Scholar 

  • Strebel K, Klimkait T, Martin MA. (1988) A novel gene of HIV-1, VPU, and its 16-kilodalton product. Science 241: 1221–3.

    Article  PubMed  CAS  Google Scholar 

  • Terwilliger E, Sodroski JG, Rosen CA et at. (1986) Effects of mutations within the 31 orf open reading frame region of human T-cell Iymphotropic virus type III (HTLV-III/LAV on replication and cytopathogenicity. J Virol 60:754–60.

    PubMed  CAS  Google Scholar 

  • Terwilliger E, Berghoff R, Sia R et at. (1987) The art gene product of human immunodeficiency virus is required for replication. J Virol 62:655–8.

    Google Scholar 

  • Wain-Hobson S. (1989) HIV genome variability in vivo. AIDS 3 (suppl 1):s13–18.

    Article  PubMed  Google Scholar 

  • Weber IN, Jeffries DJ. (1990) Humoral immune responses to HIV. In: Gottlieb M, Pinching AJ, Jeffries DJ, eds. Current opinion on HIV. A Wiley; London, 1990.

    Google Scholar 

  • Weber IN, Clapham PR, Weiss RA et at. (1987) Human immunodeficiency virus infection in two cohorts of homosexual men: neutralising sera and association of antigag antibody with prognosis. Lancet i:119–22.

    Article  Google Scholar 

  • Weiss R. (1985) Human T-cell retroviruses. In: Weiss Retai, eds. RNA tumor viruses, 2nd edn, vol 2, Supplements and appendices. Cold Spring Harbor Laboratory: New York, 405–85.

    Google Scholar 

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Authors
  1. J. N. Weber
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Editors and Affiliations

  1. Institute of Neurology, The National Hospital, Queen Square, WC1N 3BG, London, UK

    Francesco Scaravilli MD, PhD, FRCPath (Reader in Neuropathology) (Reader in Neuropathology)

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© 1993 Springer-Verlag London Limited

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Weber, J.N. (1993). HIV Infection: A Cellular Approach. In: Scaravilli, F. (eds) The Neuropathology of HIV Infection. Springer, London. https://doi.org/10.1007/978-1-4471-1957-9_1

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  • DOI: https://doi.org/10.1007/978-1-4471-1957-9_1

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1959-3

  • Online ISBN: 978-1-4471-1957-9

  • eBook Packages: Springer Book Archive

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