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Structure and Evolution of the Apolipoprotein and Lipase Gene Families

  • L. Chan
  • W. Hide
  • Yau-Wen Yang
  • Wen-Hsiung Li
Part of the Argenteuil Symposia book series (ARGENTEUIL)

Abstract

The plasma lipoproteins are the transport vehicles that deliver lipids from the liver and intestine to the peripheral tissues for disposal, and in turn, they capture some of the peripherally derived lipids and return them to the liver, where they are metabolized. Lipoprotein lipase (LPL) and hepatic triglyceride Lipase (HL) are enzymes located on the vascular endothelial surface that modify, through lipid hydrolysis, the circulating lipoprotein particles. On the surface of these particles are the apolipoproteins, the protein constitutents which are essential for the structure and stability of the different lipoprotein classes. In addition to their structural role, the apolipoproteins also serve other diverse functions, e.g. as ligands for specific cell surface receptors (apo E and apo B-100) and enzyme activators (apo C-II and apo A-I).

Keywords

Pancreatic Lipase Human Apolipoprotein Exon Shuffling High Substitution Rate Hepatic Triglyceride Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 1992

Authors and Affiliations

  • L. Chan
  • W. Hide
  • Yau-Wen Yang
  • Wen-Hsiung Li

There are no affiliations available

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