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Clinical Use of SPET Imaging in Psychiatric and Neurological Disease

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Book cover Neuroactivation and Neuroimaging with SPET

Abstract

Recent advances in SPET technology have produced increased sensitivity and resolution of SPET systems (see Chaps. 2 and 3), allowing the technique to be applied in new and exciting ways to the understanding of clinical disease, particularly in the expanding fields of neurology and psychiatry. Functional neuroimaging has allowed clinicians to ‘bypass the skull’ and examine the active human brain in health and disease. SPET can aid doctors as never before as they make complex clinical decisions about patients.

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References

  • Adams RJ, Victor M (1986) The principles of neurology. McGraw-Hill, New York

    Google Scholar 

  • Bajc M, Medved V, Basic M et al. (1989) Acute effect of electroconvulsive therapy on brain perfusion assessed by 99mTc-hexamethylpropylene-amineoxime and single photon emission tomography. Acta Psychiatr Scand 80:421–126

    Article  PubMed  CAS  Google Scholar 

  • Battistella PA, Ruffilli R, Pozza FD et al. (1990) 99Tc-HMPAO SPET in pediatric migraine. Headache 30:646–649

    Article  PubMed  CAS  Google Scholar 

  • Baxter LR, Schwartz JM, Mazziotta JC et al. (1988) Cerebral glucose metabolic rates in non-depressed patients with obsessive-compulsive disorder. Am J Psychiatry 145:1560–1563

    PubMed  Google Scholar 

  • Schwartz JM, Guze BH, Bergman K, Szuba MP (1990) PET imaging in obsessive compulsive disorder with and without depression. J Clin Psychiatry 51:61–69

    PubMed  Google Scholar 

  • Brickner RM, Rosner AA, Munro R (1940) Physiological aspects of the obsessive state. Psychosom Med 2:369–383

    Google Scholar 

  • Buell U, Braun H, Ferbert A et al. (1988) Combined SPECT imaging of regional cerebral blood flow and blood volume to assess regional cerebral perfusion reserve in patients with cerebrovascular disease. Nucl Med 27:51–56

    CAS  Google Scholar 

  • Buell U, Reiche W, Weiller C et al. (1990) Binswanger’s disease (BD): results of brain SPET (flow-volume) compared to MRI. Eur J Nucl Med 16:419 (abstr)

    Google Scholar 

  • Burns A, Philpott MP, Costa DC et al. (1989) The investigation of Alzheimer’s disease with single photon emission tomography. J Neurol Neurosurg Psychiatry 52:248–253

    Article  PubMed  CAS  Google Scholar 

  • Cambier J. Masson C, Benammou S, Robine B (1988) La graphomanie, activité graphique compulsive manifestation d’un gliome fronto-calleux. Rev Neur 144:158–164

    CAS  Google Scholar 

  • Cohen MB, Lake RR, Graham LS et al. (1989) Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia. J Nucl Med 30:1616–1620

    PubMed  CAS  Google Scholar 

  • Costa DC, Ell RJ, Burns A, Philpot M, Levy R (1988) rCBF tomograms and Tc-HMPAO in patientswith dementia (Alzheimer’s type and HIV) and Parkinson’s disease: initial results. J Cereb Blood Flow 8:109–115

    Article  Google Scholar 

  • Courchesne E, Yeung-Courchesne R, Press GA, Hesselink JR, Jernigan TL (1988) Hypoplasia of cerebellar vermal lobules VI and VII in autism. N Engl J Med 318:1349–1354

    Article  PubMed  CAS  Google Scholar 

  • Deisenhammer E, Reisecker F, Leblhuber F, Holl K, Markut H, Trenkler J, Schneider I (1989) Single photon emission-computed tomography in the differential diagnosis of dementia. Dtsch Med Wochenschr 114:1639–1644

    Article  PubMed  CAS  Google Scholar 

  • Denays R, Tondeur M, Foulon M et al. (1989) Regional brain blood flow in congenital dysphasia: studies with technetium-99m-HMPAO SPECT. J Nucl Med 30:1825–1829

    PubMed  CAS  Google Scholar 

  • Denays R, Tondeur M, Toppet V et al. (1990) Cerebral palsy: initial experience with Tc-99mHMPAO SPECT of the brain. Radiology 175:111–116

    PubMed  CAS  Google Scholar 

  • Duncan R, Patterson J, Hadley DM et al. (1990) CT, MR and SPECT imaging in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 53:11–15

    Article  PubMed  CAS  Google Scholar 

  • Ell PJ, Cullum I, Costa DC (1985) Regional cerebral blood flow mapping with a new Tc-99m-labelled compound. Lancet ii:50–51

    Article  Google Scholar 

  • Gaffney GR, Kuperman S, Tsai LY, Minchin S (1989) Forebrain structures in infantile autism. J Am Acad Child Adolesc Psychiatry 28:534–537

    Article  PubMed  CAS  Google Scholar 

  • Gemmell HG, Sharp PF, Besson JA et al. (1987) Differential diagnosis in dementia using the cerebral blood flow agent 99mTc-HMPAO: a SPECT study. J Comput Assist Tomogr 11:398–402

    Article  PubMed  CAS  Google Scholar 

  • George MS, Costa DC, Kouris K, Ring H, Ell PJ (1991a) 99Tcm-HMPAO abnormalities in infantile autism. Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)

    Google Scholar 

  • George MS, Robertson MM, Costa DC, Trimble MR, Ell PJ (1991b) HMPAO SPECT scans of co-morbid OCD/GTS patients. Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)

    Google Scholar 

  • George MS, Melvin JA, Kellner CH (1991c) Obsessive-compulsive symptoms in neurologic disease. Beh Neurol (in press)

    Google Scholar 

  • George MS, Robertson MM, Costa DC, Ell PJ (1991d) D2 receptor activity in Tourette syndrome (GTS). Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)

    Google Scholar 

  • Gibbs JM, Wise RJS, Lenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet ii:310–314

    Article  Google Scholar 

  • Hamlin CL, Swayne LC, Liebowitz MR (1989) Striatal IMP-SPECT decrease in obsessive-compulsive disorder, normalized by pharmacotherapy. Neuropsychia, Neuropsychol Beh Neurol 2:290–300

    Google Scholar 

  • Hashimoto T, Tayama M, Mori K, Fujino K, Miyazaki M, Kuroda Y (1989) Magnetic resonance imaging in autism: preliminary report. Neuropediatrics 20:143–146

    Article  Google Scholar 

  • Hawton K, Shepstone B, Soper N, Reznek L (1990) Single-photon emission computerized tomography (SPECT) in schizophrenia. Br J Psychiatry 156:425–427

    Article  PubMed  CAS  Google Scholar 

  • Heh CW, Smith R, Wu J et al. (1989) Positron emission tomography of the cerebellum in autism. Am J Psychiatry 146:242–245

    PubMed  CAS  Google Scholar 

  • Herold S, Frackowiak RS, Le Couteur A, Rutter M, Howlin P (1988) Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychol Med 18:823–831

    Article  PubMed  CAS  Google Scholar 

  • Holman BL (1986) Perfusion and receptor SPECT in the dementias. J Nucl Med 27:855–860

    PubMed  CAS  Google Scholar 

  • Holman BL, Tumeh SS (1990) Single-photon emission computed tomography (SPECT). JAMA 263:561–564

    Article  PubMed  CAS  Google Scholar 

  • Horwitz B, Rumsey JM, Grady CL, Rapoport SI (1988) The cerebral metabolic landscape in autism: intercorrelations of regional glucose utilization. Arch Neurol 45:749–755

    PubMed  CAS  Google Scholar 

  • Johnson KA, Holman BL, Rosen TJ, Nagel JS, English RJ, Growdon JH (1991) I-123 IMP SPECT is accurate in the diagnosis of Alzheimer’s disease. Arch Intern Med (in press)

    Google Scholar 

  • Katz A, Bose A, Lind SJ, Spencer SS (1990) SPECT in patients with epilepsia partialis continua. Neurology 40:1848–1850

    PubMed  CAS  Google Scholar 

  • Kim KT, Black KL, Marciano D et al. (1990) Thallium-201 SPECT imaging of brain tumors: methods and results. J Nucl Med 31:965–969

    PubMed  CAS  Google Scholar 

  • Knapp WH, Kummer R, Kubler W (1986) Imaging of cerebral blood flow-to-volume distribution using SPECT. J Nucl Med 27: 465–470

    PubMed  CAS  Google Scholar 

  • Kung HF, Alavi A, Chang W et al. (1990) In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans. J Nucl Med 31:573–579

    PubMed  CAS  Google Scholar 

  • Langen KJ, Coenen HH, Roosen N et al. (1990) SPECT studies of brain tumors with L-3-[123I]iodo-alpha-methyl tyrosine: comparison with PET, 124IMT and first clinical results. J Nucl Med 31:281–286

    PubMed  CAS  Google Scholar 

  • Laplane D, Widlocher D, Pillon B, Baulac M, Binoux F (1981) Comportement compulsif d’allure obsessionnelle par necrose circonscrite bilaterale pallido-striatale. Rev Neurol 137:269–276

    PubMed  CAS  Google Scholar 

  • Laplane D, Levasseur M, Pillon B et al. (1989) Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. Brain 112:699–725

    Article  PubMed  Google Scholar 

  • Lauritzen M, Olsen TS, Lassen NA, Paulson OB (1983) Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 13:633–641

    Article  PubMed  CAS  Google Scholar 

  • Levine SR, Welch KMA, Ewing JR, Robertson WM (1987) Asymmetric cerebral blood flow patterns in migraine. Cephalagia 7:245–248

    Article  CAS  Google Scholar 

  • Lou HC, Henriksen L, Bruhn P (1990) Focal cerebral dysfunction in developmental learning disabilities. Lancet 335:8–11

    Article  PubMed  CAS  Google Scholar 

  • Mazziotta JC (1989) Huntington’s disease: studies with structural imaging techniques and positron emission tomography. Semin Neurol 9:360–369

    Article  PubMed  CAS  Google Scholar 

  • Maurer AH, Siegel JA, Comerota AJ, Morgan WA, Johnson MH (1990) SPECT quantification of cerebral ischemia before and after carotid endarterectomy. J Nucl Med 31:1412–1420

    PubMed  CAS  Google Scholar 

  • McKeon J, McGuffin P, Robinson P (1984) Obsessive-compulsive neurosis following head injury: a report of four cases. Br J Psychiatry 144:190–192

    Article  PubMed  CAS  Google Scholar 

  • Montaldi D, Brooks DN, McColl JH et al. (1990) Measurements of regional cerebral blood flow and cognitive performance in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 53:33–38 Mountz JM, Modell JG, Foster NL et al. (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. J Nucl Med 31:61–66

    Article  PubMed  CAS  Google Scholar 

  • Mountz JM, Modell JG, Foster NL et al. (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. J Nucl Med 31:61–66

    PubMed  CAS  Google Scholar 

  • Murakami JW, Courchesne E, Press GA, Yeung-Courchesne R, Hesselink JR (1989) Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia. Arch Neurol 46:689–694

    PubMed  CAS  Google Scholar 

  • Neary D, Snowden JS, Mann DMA, Northen B, Goulding JP, Macdermott N (1990) Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry 53:23–32

    Article  PubMed  CAS  Google Scholar 

  • Nordahl TE, Benkelfat C, Semple WE et al. (1989) Cerebral glucose metabolic rates in obsessive-compulsive disorder. Neuropsychopharmacology 2:23–28 (abstr)

    Article  PubMed  CAS  Google Scholar 

  • O’Connel RA, Van Heertum RL, Billick SB, Holt AR, Gonzalez A, Notardonato H, Luck D, King LN (1989) Single photon emission computed tomography (SPECT) with IMP in the differential diagnosis of psychiatric disorders. J Neuropsychiatry 1:145–153

    Google Scholar 

  • Oleson J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9:344–352

    Article  Google Scholar 

  • Paulman RG, Devous MD, Gregory RR et al. (1990) Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function. Biol Psychiatry 27:377–399

    Article  PubMed  CAS  Google Scholar 

  • Penfield W, Rasmussen T (1950) The cerebral cortex of man. Macmillan, New York

    Google Scholar 

  • Piven J, Berthier ML, Starkstein SE, Nehme E, Pearlson G, Folstein S (1990) Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. Am J Psychiatry 147:734–739

    PubMed  CAS  Google Scholar 

  • Plioplys AV, Hemmens SE, Regan CM (1990) Expression of a neural cell adhesion molecule serum fragment is depressed in autism. J Neuropsychiatry 2:413–417

    CAS  Google Scholar 

  • Podreka I, Suess E, Goldenberg G et al. (1987) Initial experience with technetium-99m-HM-PAO brain SPECT. J Nucl Med 28:1657–1666

    PubMed  CAS  Google Scholar 

  • Rango M, Candelise L, Perani D et al. (1989) Cortical pathophysiology and clinical neurologic abnormalities in acute cerebral ischemia. A serial study with single photon emission computed tomography. Arch Neurol 46:1318–1322

    Google Scholar 

  • Reed BR, Jagust WJ, Seab JP, Ober BA (1989) Memory and regional cerebral blood flow in mildly symptomatic Alzheimer’s disease. Neurology 39:1537–1539

    PubMed  CAS  Google Scholar 

  • Rubinstein M, Denays R, Ham HR (1989) Functional imaging of brain maturation in humans using iodine-123-iodoamphetamine and SPECT. J Nucl Med 30:1982–1985

    PubMed  CAS  Google Scholar 

  • Rumsey JM, Duara R, Grady C et al. (1985) Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. Arch Gen Psych 42:488–455

    Google Scholar 

  • Sakai F, Nakazawa K, Tazaki Y et al. (1985) Regional cerebral blood volume and hematocrit measured in normal human volunteers by SPECT. J Cerebr Blood Flow Metab 5:207–213

    Article  CAS  Google Scholar 

  • Schilder P (1938) The organic background of obsessions and compulsions. Am J Psychiatry 95:1397–1413

    Google Scholar 

  • Schlake HP, Bottger IG, Grotemeyer KH, Husstedt IW (1989) Brain imaging with 123I-IMP SPECT in migraine between attacks. Headache 29:344–349

    Article  PubMed  CAS  Google Scholar 

  • Schwartz JM, Speed NM, Mountz JM, Gross MD, Modell JG, Kuhl DE (1990) 99mTc-hexamethyl-propyleneamine oxime single photon emission CT in poststroke depression. Am J Psychiatry 147:242–244

    PubMed  CAS  Google Scholar 

  • Schwartz JM, Baxter LR, Mazziotta JC et al. (1987) The differential diagnosis of depression: relevance of positron emission tomography studies of cerebral glucose metabolism to the bipolar-unipolar dichotomy. JAMA 258:1368–1374

    Article  PubMed  CAS  Google Scholar 

  • Seibyl JP, Krystal JH, Goodman WK, Price LH (1989) Obsessive-compulsive symptoms in a patient with a right frontal lobe lesion. Neuropsychia, Neuropsychol Beh Neurol 1:295–299

    Google Scholar 

  • Shahar E, Gilday DL, Hwang PA, Cohen EK, Lambert R (1990) Pediatric cerebrovascular disease: alterations of regional cerebral blood flow detected by 99mTc-HMPAO SPECT. Arch Neurol 47:578–584

    PubMed  CAS  Google Scholar 

  • Shen W, Lee BI, Park HM et al. (1990) HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. J Nucl Med 31:1280–1284

    PubMed  CAS  Google Scholar 

  • Sherman M, Nass R, Shapiro T (1984) Regional cerebral blood flow in infantile autism. J Autism Dev Dis 4:438–440

    Google Scholar 

  • Smith DF, Smith FW, Knight RS, Roberts RC, Gemmell HG (1989) 99Tcm-HMPAO single photon emission computed tomography in partial epilepsy: a preliminary report. Br J Radiol 62:970– 973

    Article  PubMed  CAS  Google Scholar 

  • Smith FW, Gemmell HG, Sharp PF, Besson JA (1988) Technetium-99m HMPAO imaging in patients with basal ganglia disease. Br J Radiol 61:914–920

    Article  PubMed  CAS  Google Scholar 

  • Stilhard G, Landis T, Schiess R, Regard M, Sialer G (1990) Bitemporal hypoperfusion in transient global amnesia: 99mTc-HM-PAO SPECT and neuropsychological findings during and after an attack. J Neurol Neurosurg Psychiatry 53:339–342

    Article  Google Scholar 

  • Stuss DT, Benson DF (1986) The frontal lobes. Raven Press, New York

    Google Scholar 

  • Suddath RL, Christison GW, Torrey EF, Casanova M, Weinberger DR (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 322:789–794

    Article  PubMed  CAS  Google Scholar 

  • Swedo SE, Schapiro MB, Grady CL (1989a) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psych 46:518–523

    CAS  Google Scholar 

  • Swedo SE, Rapoport JL, Cheslow DL et al. (1989b) High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea. Am J Psychiatry 146:246–249

    CAS  Google Scholar 

  • Talairach J, Bancaud J, Geier S et al. (1973) The cingulate gyrus and human behaviour. Electroencephalogr Clin Neurol 34:45–52

    Article  CAS  Google Scholar 

  • Terry RD, Katzman R (1983) Senile dementia of the Alzheimer’s type. Ann Neurol 14:497–506

    Article  PubMed  CAS  Google Scholar 

  • Tonkonogy J, Barreira P (1989) Obsessive-compulsive disorder and caudate-frontal lesion.Neuropsychia, Neuropsychol Beh Neurol 2:203–209

    Google Scholar 

  • Trimble MR (1991) The psychoses of epilepsy. Raven Press, New York

    Google Scholar 

  • Weilburg JB, Mesulam M, Weintraub S, Buonanno F, Jenike M, Stakes JW (1989) Focal striatal abnormalities in a patient with obsessive-compulsive disorder. Arch Neurol 46:233–235

    Google Scholar 

  • Wohlfart G, Ingvar DH, Hellberg A (1961) Compulsory shouting (Benedek’s ‘klazomania’) associated with oculogyric spasms in chronic epidemic encephalitis. Acta Psychiatr Scand 36:369–377

    Article  PubMed  CAS  Google Scholar 

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George, M.S., Ring, H.A., Costa, D.C., Ell, P.J., Kouris, K., Jarritt, P.H. (1991). Clinical Use of SPET Imaging in Psychiatric and Neurological Disease. In: Neuroactivation and Neuroimaging with SPET. Springer, London. https://doi.org/10.1007/978-1-4471-1901-2_4

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  • DOI: https://doi.org/10.1007/978-1-4471-1901-2_4

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