Clinical Use of SPET Imaging in Psychiatric and Neurological Disease

  • Mark S. George
  • Howard A. Ring
  • Durval C. Costa
  • Peter J. Ell
  • Kypros Kouris
  • Peter H. Jarritt

Abstract

Recent advances in SPET technology have produced increased sensitivity and resolution of SPET systems (see Chaps. 2 and 3), allowing the technique to be applied in new and exciting ways to the understanding of clinical disease, particularly in the expanding fields of neurology and psychiatry. Functional neuroimaging has allowed clinicians to ‘bypass the skull’ and examine the active human brain in health and disease. SPET can aid doctors as never before as they make complex clinical decisions about patients.

Keywords

Cholesterol Dopamine Meningitis Triad Carbamazepine 

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References

  1. Adams RJ, Victor M (1986) The principles of neurology. McGraw-Hill, New YorkGoogle Scholar
  2. Bajc M, Medved V, Basic M et al. (1989) Acute effect of electroconvulsive therapy on brain perfusion assessed by 99mTc-hexamethylpropylene-amineoxime and single photon emission tomography. Acta Psychiatr Scand 80:421–126PubMedCrossRefGoogle Scholar
  3. Battistella PA, Ruffilli R, Pozza FD et al. (1990) 99Tc-HMPAO SPET in pediatric migraine. Headache 30:646–649PubMedCrossRefGoogle Scholar
  4. Baxter LR, Schwartz JM, Mazziotta JC et al. (1988) Cerebral glucose metabolic rates in non-depressed patients with obsessive-compulsive disorder. Am J Psychiatry 145:1560–1563PubMedGoogle Scholar
  5. Schwartz JM, Guze BH, Bergman K, Szuba MP (1990) PET imaging in obsessive compulsive disorder with and without depression. J Clin Psychiatry 51:61–69PubMedGoogle Scholar
  6. Brickner RM, Rosner AA, Munro R (1940) Physiological aspects of the obsessive state. Psychosom Med 2:369–383Google Scholar
  7. Buell U, Braun H, Ferbert A et al. (1988) Combined SPECT imaging of regional cerebral blood flow and blood volume to assess regional cerebral perfusion reserve in patients with cerebrovascular disease. Nucl Med 27:51–56Google Scholar
  8. Buell U, Reiche W, Weiller C et al. (1990) Binswanger’s disease (BD): results of brain SPET (flow-volume) compared to MRI. Eur J Nucl Med 16:419 (abstr)Google Scholar
  9. Burns A, Philpott MP, Costa DC et al. (1989) The investigation of Alzheimer’s disease with single photon emission tomography. J Neurol Neurosurg Psychiatry 52:248–253PubMedCrossRefGoogle Scholar
  10. Cambier J. Masson C, Benammou S, Robine B (1988) La graphomanie, activité graphique compulsive manifestation d’un gliome fronto-calleux. Rev Neur 144:158–164Google Scholar
  11. Cohen MB, Lake RR, Graham LS et al. (1989) Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia. J Nucl Med 30:1616–1620PubMedGoogle Scholar
  12. Costa DC, Ell RJ, Burns A, Philpot M, Levy R (1988) rCBF tomograms and Tc-HMPAO in patientswith dementia (Alzheimer’s type and HIV) and Parkinson’s disease: initial results. J Cereb Blood Flow 8:109–115CrossRefGoogle Scholar
  13. Courchesne E, Yeung-Courchesne R, Press GA, Hesselink JR, Jernigan TL (1988) Hypoplasia of cerebellar vermal lobules VI and VII in autism. N Engl J Med 318:1349–1354PubMedCrossRefGoogle Scholar
  14. Deisenhammer E, Reisecker F, Leblhuber F, Holl K, Markut H, Trenkler J, Schneider I (1989) Single photon emission-computed tomography in the differential diagnosis of dementia. Dtsch Med Wochenschr 114:1639–1644PubMedCrossRefGoogle Scholar
  15. Denays R, Tondeur M, Foulon M et al. (1989) Regional brain blood flow in congenital dysphasia: studies with technetium-99m-HMPAO SPECT. J Nucl Med 30:1825–1829PubMedGoogle Scholar
  16. Denays R, Tondeur M, Toppet V et al. (1990) Cerebral palsy: initial experience with Tc-99mHMPAO SPECT of the brain. Radiology 175:111–116PubMedGoogle Scholar
  17. Duncan R, Patterson J, Hadley DM et al. (1990) CT, MR and SPECT imaging in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 53:11–15PubMedCrossRefGoogle Scholar
  18. Ell PJ, Cullum I, Costa DC (1985) Regional cerebral blood flow mapping with a new Tc-99m-labelled compound. Lancet ii:50–51CrossRefGoogle Scholar
  19. Gaffney GR, Kuperman S, Tsai LY, Minchin S (1989) Forebrain structures in infantile autism. J Am Acad Child Adolesc Psychiatry 28:534–537PubMedCrossRefGoogle Scholar
  20. Gemmell HG, Sharp PF, Besson JA et al. (1987) Differential diagnosis in dementia using the cerebral blood flow agent 99mTc-HMPAO: a SPECT study. J Comput Assist Tomogr 11:398–402PubMedCrossRefGoogle Scholar
  21. George MS, Costa DC, Kouris K, Ring H, Ell PJ (1991a) 99Tcm-HMPAO abnormalities in infantile autism. Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)Google Scholar
  22. George MS, Robertson MM, Costa DC, Trimble MR, Ell PJ (1991b) HMPAO SPECT scans of co-morbid OCD/GTS patients. Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)Google Scholar
  23. George MS, Melvin JA, Kellner CH (1991c) Obsessive-compulsive symptoms in neurologic disease. Beh Neurol (in press)Google Scholar
  24. George MS, Robertson MM, Costa DC, Ell PJ (1991d) D2 receptor activity in Tourette syndrome (GTS). Proceedings of the American Psychiatric Association Annual Meeting (abstr) (in press)Google Scholar
  25. Gibbs JM, Wise RJS, Lenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet ii:310–314CrossRefGoogle Scholar
  26. Hamlin CL, Swayne LC, Liebowitz MR (1989) Striatal IMP-SPECT decrease in obsessive-compulsive disorder, normalized by pharmacotherapy. Neuropsychia, Neuropsychol Beh Neurol 2:290–300Google Scholar
  27. Hashimoto T, Tayama M, Mori K, Fujino K, Miyazaki M, Kuroda Y (1989) Magnetic resonance imaging in autism: preliminary report. Neuropediatrics 20:143–146CrossRefGoogle Scholar
  28. Hawton K, Shepstone B, Soper N, Reznek L (1990) Single-photon emission computerized tomography (SPECT) in schizophrenia. Br J Psychiatry 156:425–427PubMedCrossRefGoogle Scholar
  29. Heh CW, Smith R, Wu J et al. (1989) Positron emission tomography of the cerebellum in autism. Am J Psychiatry 146:242–245PubMedGoogle Scholar
  30. Herold S, Frackowiak RS, Le Couteur A, Rutter M, Howlin P (1988) Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychol Med 18:823–831PubMedCrossRefGoogle Scholar
  31. Holman BL (1986) Perfusion and receptor SPECT in the dementias. J Nucl Med 27:855–860PubMedGoogle Scholar
  32. Holman BL, Tumeh SS (1990) Single-photon emission computed tomography (SPECT). JAMA 263:561–564PubMedCrossRefGoogle Scholar
  33. Horwitz B, Rumsey JM, Grady CL, Rapoport SI (1988) The cerebral metabolic landscape in autism: intercorrelations of regional glucose utilization. Arch Neurol 45:749–755PubMedGoogle Scholar
  34. Johnson KA, Holman BL, Rosen TJ, Nagel JS, English RJ, Growdon JH (1991) I-123 IMP SPECT is accurate in the diagnosis of Alzheimer’s disease. Arch Intern Med (in press)Google Scholar
  35. Katz A, Bose A, Lind SJ, Spencer SS (1990) SPECT in patients with epilepsia partialis continua. Neurology 40:1848–1850PubMedGoogle Scholar
  36. Kim KT, Black KL, Marciano D et al. (1990) Thallium-201 SPECT imaging of brain tumors: methods and results. J Nucl Med 31:965–969PubMedGoogle Scholar
  37. Knapp WH, Kummer R, Kubler W (1986) Imaging of cerebral blood flow-to-volume distribution using SPECT. J Nucl Med 27: 465–470PubMedGoogle Scholar
  38. Kung HF, Alavi A, Chang W et al. (1990) In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans. J Nucl Med 31:573–579PubMedGoogle Scholar
  39. Langen KJ, Coenen HH, Roosen N et al. (1990) SPECT studies of brain tumors with L-3-[123I]iodo-alpha-methyl tyrosine: comparison with PET, 124IMT and first clinical results. J Nucl Med 31:281–286PubMedGoogle Scholar
  40. Laplane D, Widlocher D, Pillon B, Baulac M, Binoux F (1981) Comportement compulsif d’allure obsessionnelle par necrose circonscrite bilaterale pallido-striatale. Rev Neurol 137:269–276PubMedGoogle Scholar
  41. Laplane D, Levasseur M, Pillon B et al. (1989) Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. Brain 112:699–725PubMedCrossRefGoogle Scholar
  42. Lauritzen M, Olsen TS, Lassen NA, Paulson OB (1983) Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 13:633–641PubMedCrossRefGoogle Scholar
  43. Levine SR, Welch KMA, Ewing JR, Robertson WM (1987) Asymmetric cerebral blood flow patterns in migraine. Cephalagia 7:245–248CrossRefGoogle Scholar
  44. Lou HC, Henriksen L, Bruhn P (1990) Focal cerebral dysfunction in developmental learning disabilities. Lancet 335:8–11PubMedCrossRefGoogle Scholar
  45. Mazziotta JC (1989) Huntington’s disease: studies with structural imaging techniques and positron emission tomography. Semin Neurol 9:360–369PubMedCrossRefGoogle Scholar
  46. Maurer AH, Siegel JA, Comerota AJ, Morgan WA, Johnson MH (1990) SPECT quantification of cerebral ischemia before and after carotid endarterectomy. J Nucl Med 31:1412–1420PubMedGoogle Scholar
  47. McKeon J, McGuffin P, Robinson P (1984) Obsessive-compulsive neurosis following head injury: a report of four cases. Br J Psychiatry 144:190–192PubMedCrossRefGoogle Scholar
  48. Montaldi D, Brooks DN, McColl JH et al. (1990) Measurements of regional cerebral blood flow and cognitive performance in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 53:33–38 Mountz JM, Modell JG, Foster NL et al. (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. J Nucl Med 31:61–66PubMedCrossRefGoogle Scholar
  49. Mountz JM, Modell JG, Foster NL et al. (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. J Nucl Med 31:61–66PubMedGoogle Scholar
  50. Murakami JW, Courchesne E, Press GA, Yeung-Courchesne R, Hesselink JR (1989) Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia. Arch Neurol 46:689–694PubMedGoogle Scholar
  51. Neary D, Snowden JS, Mann DMA, Northen B, Goulding JP, Macdermott N (1990) Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry 53:23–32PubMedCrossRefGoogle Scholar
  52. Nordahl TE, Benkelfat C, Semple WE et al. (1989) Cerebral glucose metabolic rates in obsessive-compulsive disorder. Neuropsychopharmacology 2:23–28 (abstr)PubMedCrossRefGoogle Scholar
  53. O’Connel RA, Van Heertum RL, Billick SB, Holt AR, Gonzalez A, Notardonato H, Luck D, King LN (1989) Single photon emission computed tomography (SPECT) with IMP in the differential diagnosis of psychiatric disorders. J Neuropsychiatry 1:145–153Google Scholar
  54. Oleson J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9:344–352CrossRefGoogle Scholar
  55. Paulman RG, Devous MD, Gregory RR et al. (1990) Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function. Biol Psychiatry 27:377–399PubMedCrossRefGoogle Scholar
  56. Penfield W, Rasmussen T (1950) The cerebral cortex of man. Macmillan, New YorkGoogle Scholar
  57. Piven J, Berthier ML, Starkstein SE, Nehme E, Pearlson G, Folstein S (1990) Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. Am J Psychiatry 147:734–739PubMedGoogle Scholar
  58. Plioplys AV, Hemmens SE, Regan CM (1990) Expression of a neural cell adhesion molecule serum fragment is depressed in autism. J Neuropsychiatry 2:413–417Google Scholar
  59. Podreka I, Suess E, Goldenberg G et al. (1987) Initial experience with technetium-99m-HM-PAO brain SPECT. J Nucl Med 28:1657–1666PubMedGoogle Scholar
  60. Rango M, Candelise L, Perani D et al. (1989) Cortical pathophysiology and clinical neurologic abnormalities in acute cerebral ischemia. A serial study with single photon emission computed tomography. Arch Neurol 46:1318–1322Google Scholar
  61. Reed BR, Jagust WJ, Seab JP, Ober BA (1989) Memory and regional cerebral blood flow in mildly symptomatic Alzheimer’s disease. Neurology 39:1537–1539PubMedGoogle Scholar
  62. Rubinstein M, Denays R, Ham HR (1989) Functional imaging of brain maturation in humans using iodine-123-iodoamphetamine and SPECT. J Nucl Med 30:1982–1985PubMedGoogle Scholar
  63. Rumsey JM, Duara R, Grady C et al. (1985) Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. Arch Gen Psych 42:488–455Google Scholar
  64. Sakai F, Nakazawa K, Tazaki Y et al. (1985) Regional cerebral blood volume and hematocrit measured in normal human volunteers by SPECT. J Cerebr Blood Flow Metab 5:207–213CrossRefGoogle Scholar
  65. Schilder P (1938) The organic background of obsessions and compulsions. Am J Psychiatry 95:1397–1413Google Scholar
  66. Schlake HP, Bottger IG, Grotemeyer KH, Husstedt IW (1989) Brain imaging with 123I-IMP SPECT in migraine between attacks. Headache 29:344–349PubMedCrossRefGoogle Scholar
  67. Schwartz JM, Speed NM, Mountz JM, Gross MD, Modell JG, Kuhl DE (1990) 99mTc-hexamethyl-propyleneamine oxime single photon emission CT in poststroke depression. Am J Psychiatry 147:242–244PubMedGoogle Scholar
  68. Schwartz JM, Baxter LR, Mazziotta JC et al. (1987) The differential diagnosis of depression: relevance of positron emission tomography studies of cerebral glucose metabolism to the bipolar-unipolar dichotomy. JAMA 258:1368–1374PubMedCrossRefGoogle Scholar
  69. Seibyl JP, Krystal JH, Goodman WK, Price LH (1989) Obsessive-compulsive symptoms in a patient with a right frontal lobe lesion. Neuropsychia, Neuropsychol Beh Neurol 1:295–299Google Scholar
  70. Shahar E, Gilday DL, Hwang PA, Cohen EK, Lambert R (1990) Pediatric cerebrovascular disease: alterations of regional cerebral blood flow detected by 99mTc-HMPAO SPECT. Arch Neurol 47:578–584PubMedGoogle Scholar
  71. Shen W, Lee BI, Park HM et al. (1990) HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. J Nucl Med 31:1280–1284PubMedGoogle Scholar
  72. Sherman M, Nass R, Shapiro T (1984) Regional cerebral blood flow in infantile autism. J Autism Dev Dis 4:438–440Google Scholar
  73. Smith DF, Smith FW, Knight RS, Roberts RC, Gemmell HG (1989) 99Tcm-HMPAO single photon emission computed tomography in partial epilepsy: a preliminary report. Br J Radiol 62:970– 973PubMedCrossRefGoogle Scholar
  74. Smith FW, Gemmell HG, Sharp PF, Besson JA (1988) Technetium-99m HMPAO imaging in patients with basal ganglia disease. Br J Radiol 61:914–920PubMedCrossRefGoogle Scholar
  75. Stilhard G, Landis T, Schiess R, Regard M, Sialer G (1990) Bitemporal hypoperfusion in transient global amnesia: 99mTc-HM-PAO SPECT and neuropsychological findings during and after an attack. J Neurol Neurosurg Psychiatry 53:339–342CrossRefGoogle Scholar
  76. Stuss DT, Benson DF (1986) The frontal lobes. Raven Press, New YorkGoogle Scholar
  77. Suddath RL, Christison GW, Torrey EF, Casanova M, Weinberger DR (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 322:789–794PubMedCrossRefGoogle Scholar
  78. Swedo SE, Schapiro MB, Grady CL (1989a) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psych 46:518–523Google Scholar
  79. Swedo SE, Rapoport JL, Cheslow DL et al. (1989b) High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea. Am J Psychiatry 146:246–249Google Scholar
  80. Talairach J, Bancaud J, Geier S et al. (1973) The cingulate gyrus and human behaviour. Electroencephalogr Clin Neurol 34:45–52CrossRefGoogle Scholar
  81. Terry RD, Katzman R (1983) Senile dementia of the Alzheimer’s type. Ann Neurol 14:497–506PubMedCrossRefGoogle Scholar
  82. Tonkonogy J, Barreira P (1989) Obsessive-compulsive disorder and caudate-frontal lesion.Neuropsychia, Neuropsychol Beh Neurol 2:203–209Google Scholar
  83. Trimble MR (1991) The psychoses of epilepsy. Raven Press, New YorkGoogle Scholar
  84. Weilburg JB, Mesulam M, Weintraub S, Buonanno F, Jenike M, Stakes JW (1989) Focal striatal abnormalities in a patient with obsessive-compulsive disorder. Arch Neurol 46:233–235Google Scholar
  85. Wohlfart G, Ingvar DH, Hellberg A (1961) Compulsory shouting (Benedek’s ‘klazomania’) associated with oculogyric spasms in chronic epidemic encephalitis. Acta Psychiatr Scand 36:369–377PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1991

Authors and Affiliations

  • Mark S. George
    • 1
    • 2
  • Howard A. Ring
    • 3
  • Durval C. Costa
    • 4
  • Peter J. Ell
    • 5
  • Kypros Kouris
    • 6
    • 7
  • Peter H. Jarritt
    • 8
  1. 1.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  2. 2.Department of Psychiatry and Behavioral SciencesMedical University of South CarolinaCharlestonUSA
  3. 3.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  4. 4.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  5. 5.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  6. 6.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  7. 7.University of KuwaitKuwait CityKuwait
  8. 8.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland

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