Abstract
Through the application of molecular biological techniques to the investigation of tumour biology, an understanding of some of the mechanisms involved in neoplasia is beginning to emerge. In studying tumours, it is important to determine which of the gross or submicroscopic alterations to the genome found in tumour cells are causative, and which are a consequence of transformation. In order to do this it is necessary to look for consistent changes, or changes specifically associated with the type or stage of tumour growth.
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References
Ahyai A (1988) Flow cytometric analysis of cellular DNA content in human astrocytomas and oligodendrogliomas. Neurosurg Rev 11: 177–187
Baker SJ, Fearon ER, Nigro JM et al. (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217–220
Barker D, Wright E, Nguyen K et al. (1987) Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 236: 1100–1102
Bigner SH, Mark J, Burger PC et al. (1988a) Specific chromosomal abnormalities in malignant human gliomas. Cancer Res 88: 405–411
Bigner SH, Burger PC, Wong AJ et al. (1988b) Gene amplification in malignant human gliomas: clinical and histopathologic aspects. J Neuropathol Exp Neurol 47: 191–205
Birchmeier C, Sharma S, Wigler M (1987) Expression and rearrangement of the Rosl gene in human glioblastoma cells. Proc Natl Acad Sci USA 84: 9270–9274
Brodeur GM (1989) Clinical significance of genetic rearrangements in human neuroblastomas. Clin Chem 35(Suppl 7): B38–B42
Cavenee WK, Dryja TP, Phillips RA et al. (1983) Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305: 779–784
Chung R, Farmer G, Anderson K et al. (1989) Distinct deletion on the short arm of chromosome 17 in tumorigenesis of neurofibrosarcomas and astrocytomas. Am J Hum Genet 45: A17
Davies KE, Read AP (1988) Molecular Basis of Inherited Diseases. IRL Press, Oxford
Dominici C, Negroni A, Romeo A et al. (1989) Association of near-diploid DNA content and N-myc amplification in neuroblastomas. Clin Exp Metastasis 7: 202–211
Dumanski JP, Carlbom E, Collins VP, Nordenskjold M (1987) Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 84: 9275–9279
Engelhard HH, Butler AB, Bauer KD (1989) Quantification of the c-myc oncoprotein in human glioblastoma cells and tumour tissue. J Neurosurg 71: 224–232
Fain PR, Goldgar DE, Wallace MR et al. (1989) Refined physical and genetic mapping of the NF1 region on chromosome 17. Am J Hum Genet 45: 721–728
Farber E (1984) The multistep nature of cancer development. Cancer Res 44: 4217–4223
Fong CT, Dracopoli NC, White PS et al. (1989) Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci USA 86: 3753–3757
Fujimoto M, Fults DW, Thomas GA et al. (1989a) Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics 4: 210–214
Fujimoto M, Sheridan PJ, Sharp ZD et al. (1989b) Proto-oncogene analyses in brain tumours. J Neurosurg 70: 910–915
Fults D, Tippets RH, Thomas GA, Nakamura Y, White R (1989) Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res 49: 6572–6576
Gerosa MA, Talarico D, Fognani C et al. (1989) Overexpression of N-ras oncogene and epidermal growth factor receptor gene in human glioblastomas. J Natl Cancer Inst 81: 63–67
Gilbert F (1988) Neuro-oncogenesis: recessive genes, activated oncogenes, and chromosome abnormalities in the development of neuro-ectodermal cancers. In: Rosenberg RN, Harding AE (eds) The Molecular Biology of Neurological Disease. Butterworths, London, pp 109–124
Harding, AE (1988) Molecular genetics and neurological disease. In: Kennard C (ed) Recent Advances in Clinical Neurology 5. Churchill Livingstone, Edinburgh
Hayashi Y, Kanda N, Inaba T et al. (1989) Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1. Cancer 63: 126–132
Hermansson M, Nister M, Betsholtz C et al. (1988) Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad Sci USA 85: 7748–7752
Humphrey PA, Wong AJ, Vogelstein B et al. (1988) Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer 48: 2231–2238
James CD, Carlbom E, Dumanski JP et al. (1988) Clonal genomic alterations in glioma malignancy stages. Cancer Res 48: 5546–5551
James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee WK (1989) Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci USA 86: 2858–2862
Kinzler KW, Bigner SH, Bigner DD et al. (1987) Identification of an amplified, highly expressed gene in a human glioma. Science 236: 70–73
Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820–823
Libermann TA, Nusbaum HR, Razon N et al. (1985) Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313: 144–147
Martuza RL, Scizinger BR, Jacoby LB, Rouleau GA, Gusella JF (1988) The molecular biology of human glial tumours. Trends Neurosci 11: 22–27
Nigro JM, Baker SJ, Preisinger AC et al. (1989) Mutations in the p53 gene occur in diverse human tumour types. Nature 342: 705–708
Ritke MK, Shah R, Valentine M, Douglass EC, Tereba E (1989) Molecular analysis of chromosome 1 abnormalities in neuroblastoma. Cytogenet Cell Genet 50: 84–90
Schmidek HH (1987) The molecular genetics of nervous system tumors. J Neurosurg 67: 1–16
Scizinger BR, Martuza RL, Gusella JF (1986) Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma. Nature 322: 644–647
Scizinger BR, Rouleau GA, Ozelius LJ et al. (1987a) Common pathogenetic mechanism for three tumor types in bilateral acoustic neurofibromatosis. Science 236: 317–319
Scizinger BR, de la Monte S, Atkins L et al. (1987b) A molecular genetic approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci USA 84: 5419–5423
Scizinger BR, Rouleau GA, Ozelius LJ et al. (1987c) Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. Cell 49: 589–594
Scizinger BR, Rouleau GA, Ozelius LJ et al. (1988) Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 32: 268–269
Tory K, Brauch H, Linehan M et al. (1989) Allele deletion analysis of tumors associated with von Hippel-Lindau disease (VHL) identifies VHL as a tumor suppressor gene. Cytogenet Cell Genet 51: 1092
Trent J, Meltzer P, Rosenblum M et al. (1986) Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proc Natl Acad Sci USA 83: 470–473
Vile R (1989) Tumour suppressor genes. Br Med J 298: 1335–1336
Wertelecki W, Rouleau GA, Superneau DW et al. (1988) Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred. New Engl J Med 319: 278–283
Wong AJ, Bigner SH, Kinzler KW, Hamilton SR, Vogelstein B (1987) Increased expression of the EGF receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84: 6899–6903
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Jones, C.E., Harding, A.E. (1995). Molecular Genetics of Brain Tumours. In: Thomas, D.G.T., Graham, D.I. (eds) Malignant Brain Tumours. Springer, London. https://doi.org/10.1007/978-1-4471-1877-0_2
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DOI: https://doi.org/10.1007/978-1-4471-1877-0_2
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