Familial Motor Neuron Disease

  • J. de Belleroche
  • P. N. Leigh
  • F. Clifford Rose


Familial motor neuron disease (FMND) constitutes approximately 5%–10% of cases of motor neuron disease (MND). Whilst in most families the pattern of inheritance is consistent with an autosomal-dominant trait, with age-dependent penetrance, a few cases appear to show an autosomal-recessive mode of inheritance. Statistical analysis shows that the likelihood of chance aggregation is improbable because affected members span several generations, come from different environmental and geographical regions, and the condition does not develop in spouses.


Androgen Receptor Motor Neuron Spinal Muscular Atrophy Motor Neuron Disease Motor Neuron Disease 
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© Springer-Verlag London Limited 1995

Authors and Affiliations

  • J. de Belleroche
  • P. N. Leigh
  • F. Clifford Rose

There are no affiliations available

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