Advertisement

Some Practical Issues in the Antenatal Detection of Neural Tube Defects and Down’s Syndrome

  • N. Wald
  • H. Cuckle

Abstract

Maternal serum alphafetoprotein (AFP) and ultrasound screening for neural tube defects is now established in Britain and recently serum screening for Down’s syndrome has been introduced in a number of centres. Our purpose in this chapter is not to review the subject as a whole but to identify some practical issues that perhaps need wider recognition.

Keywords

Spina Bifida Neural Tube Defect Antenatal Diagnosis Serum Screening Affected Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cuckle HS, Wald NJ. The impact of screening for open neural tube defects in England and Wales. Prenat Diagn 1987; 7:91–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Cuckle HS, Nanchahal K, Wald NJ. Birth prevalence of Down’s syndrome in England and Wales. Prenat Diagn, in press.Google Scholar
  3. 3.
    Cuckle HS, Wald NJ, Cuckle PM. Prenatal screening and diagnosis of neural tube defects in England and Wales in 1985. Prenat Diagn 1989; 9:393–400.PubMedCrossRefGoogle Scholar
  4. 4.
    Wald NJ, Cuckle HS, Boreham J, Stirrat G. Small biparietal diameter of fetuses with spina bifida: implications for antenatal screening. Br J Obstet Gynaecol 1980; 87:219–21.PubMedCrossRefGoogle Scholar
  5. 5.
    Wald NJ, Cuckle HS, Haddow JE, Doherty RA, Knight GJ, Palomaki GE. The ultrasonographic diagnosis of open spina bifida. N Engl J Med, in press.Google Scholar
  6. 6.
    Wald NJ, Cuckle HS, Densem JW et al. Maternal serum screening for Down’s syndrome in early pregnancy. Br Med J 1988; 297:883–7.CrossRefGoogle Scholar
  7. 7.
    Cuckle HS, Wald NJ, Goodburn SF, Sneddon J, Amess JAL, Dunn SC. Measurement of activity of urea resistant neutrophil alkaline phosphatase as an antenatal screening test for Down’s syndrome. Br Med J 1990; 301:1024–6.CrossRefGoogle Scholar
  8. 8.
    Simpson JL, Elias S, Morgan CD, Shulman L, Umstot E, Anderson RN. Second trimester maternal serum human chorionic gonadotropin and unconjugated oestriol levels in blacks and whites. Lancet 1990; 335:1459–60.PubMedCrossRefGoogle Scholar
  9. 9.
    Muller F, Boué A. A single chorionic gonadotrophin assay for maternal serum screening for Down’s syndrome. Prenat Diagn 1990; 10:389–98.PubMedCrossRefGoogle Scholar
  10. 10.
    Cuckle HS, Wald NJ, Densem JW et al. The effect of smoking in pregnancy on maternal serum alpha-fetoprotein, unconjugated oestriol, human chorionic gonadotrophin, progesterone and dehydroepiandrosterone sulphate levels. Br J Obstet Gynaecol 1990; 97:272–6.PubMedCrossRefGoogle Scholar
  11. 1.
    De Bono M, Fawdry RD, Lilford RJ. Size of trials for evaluation of antenatal tests of fetal wellbeing in high risk pregnancy. J Perinai Med 1990; 18:77–87.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1991

Authors and Affiliations

  • N. Wald
  • H. Cuckle

There are no affiliations available

Personalised recommendations