The Embryo pp 101-121 | Cite as

The Role of Echography in the Diagnosis of Fetal Chromosomal Defects

  • K. H. Nicolaides
  • R. J. M. Snijders
  • C. M. Gosden


Ultrasonography plays a central role in the diagnosis of fetal chromosomal abnormalities. It is used first, for accurate dating of pregnancy which is essential in the interpretation of maternal serum alpha-fetoprotein, human chorionic gonadotropin and unconjugated oestriol; second, to enhance the safety and effectiveness of amniocentesis, placental biopsy or cordocentesis; and third, for examination of the external and internal anatomy of the fetus and the detection of major malformations, as well as more subtle ones which may be markers of chromosomal defects.


Prenatal Diagnosis Congenital Diaphragmatic Hernia Renal Agenesis Partial Trisomy Duodenal Atresia 
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Copyright information

© Springer-Verlag London Limited 1991

Authors and Affiliations

  • K. H. Nicolaides
  • R. J. M. Snijders
  • C. M. Gosden

There are no affiliations available

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