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Endocrinology and Osteoporosis

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Abstract

Although bone is commonly perceived as a metabolically inert tissue it is in fact very active, undergoing continuous renewal of its constituents by resorption of old bone and formation of new. The balance between these two processes is vital to the health of the skeleton, since an apparently small increase of resorption over formation can, over the years, lead to a clinically significant deficit of bone. Because many of the factors that influence these processes are hormonal, it is necessary to have an understanding of the effect of hormones on bone to understand both normal bone physiology and also the deleterious effects on the skeleton of many endocrine disorders.

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References

  1. Sprague RG, Randall RV, Scilassa RM et al. Cushing’s syndrome. A progressive and often fatal disease. Arch Intern Med 1956; 98:389–98.

    Google Scholar 

  2. Howland WJ, Pugh DC, Sprague RG. Roentgenological changes in the skeletal system in Cushing’s syndrome. Radiology 1958; 71:69–78.

    PubMed  Google Scholar 

  3. Need AG. Corticosteroids and osteoporosis. Aust NZ J Med 1987; 17:267–72.

    Article  CAS  Google Scholar 

  4. Francis RM, Peacock M, Marshall DH, Horsman A, Aaron JE. Spinal osteoporosis in men. Bone Mineral 1989; 5:347–57.

    Article  CAS  Google Scholar 

  5. Chen TL, Aronow L, Feldman D. Glucocorticoid receptors and inhibition of bone cell growth in primary culture. Endocrinology 1977; 100:619–28.

    Article  PubMed  CAS  Google Scholar 

  6. Manolagas SC, Anderson DC. Detection of high affinity glucocorticoid binding in rat bone. J Endocrinol 1978; 76:377–80.

    Article  Google Scholar 

  7. Peck WA, Brandt J, Miller I. Hydrocortisone-induced inhibition of protein synthesis and uridine incorporation in isolated bone cells in vitro. Proc Natl Acad Sci 1967; 57:1599–606.

    Article  PubMed  CAS  Google Scholar 

  8. Choe J, Stern P, Feldman D. Receptor mediated glucocorticoid inhibition of protein synthesis in isolated bone cells in vitro. J Steroid Biochem 1977; 9:265–71.

    Article  Google Scholar 

  9. Crilly RG, Marshall DH, Nordin BEC. Metabolic effects of corticosteroid therapy in postmenopausal women. J Steroid Biochem 1979; 11:429–33.

    Article  PubMed  CAS  Google Scholar 

  10. Stern PH. Inhibition by steroids of parathyroid induced Ca45 release from embryonic rat bone in vitro. J Pharmacol Exp Ther 1969; 168:211–17.

    PubMed  CAS  Google Scholar 

  11. Raisz LG, Trummel CL, Wener JA, Simmons H. Effect of glucocorticoids on bone resorption in tissue culture. Endocrinology 1972; 90:961–7.

    Article  PubMed  CAS  Google Scholar 

  12. Kimberg DV. Effects of vitamin D and the steroid hormones on the active transport of calcium by the intestine. N Engl J Med 1969; 280:1396–405.

    Article  PubMed  CAS  Google Scholar 

  13. Suzuki Y, Ichikawa Y, Saito E, Homma M. Importance of increased calcium excretion in the development of secondary hyperparathyroidism of patients under corticosteroid therapy. Metabolism 1983; 32:151–6.

    Article  PubMed  CAS  Google Scholar 

  14. Hahn TJ, Halstead LR, Baron DT. Effects of short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 1981; 52:111–15.

    Article  PubMed  CAS  Google Scholar 

  15. Bar-Shavit Z, Kahn AJ, Pegg LE, Stone KR, Teitelbaum SL. Glucocorticoids modulate macrophage surface oligosaccharides and their bone binding activity. J Clin Invest 1984; 73:1277–83.

    Article  PubMed  Google Scholar 

  16. Reid IR, Ibbertson HK. Calcium supplementation in the prevention of steroid-induced osteoporosis. Am J Clin Nutr 1986; 44:287–90.

    PubMed  CAS  Google Scholar 

  17. Nilsen KH, Jayson MIV, Dixon AStJ. Microcrystalline calcium hydroxyapatite compound in corticosteroid-treated rheumatoid patients: a controlled study. Br Med J 1978; 2:1124.

    Article  PubMed  CAS  Google Scholar 

  18. Lindehayn K, Trzenschik K, Buhler G, Wegner G. On the action of prednisolone and ethane-1-hydroxy-1,1-diphosphonate (EDHP) on rabbit bone. Exp Pathol 1982; 21:157–64.

    Article  Google Scholar 

  19. Ringe JD, Welzel D, Schmid K. Therapy of corticosteroid induced osteoporosis with salmon calcitonin. In: Christiansen C, Johansen JS, Riis BJ, eds. Osteoporosis 1987. Copenhagen: Osteopress ApS, 1987; 1074–6.

    Google Scholar 

  20. Reid IR, King AR, Alexander CJ, Ibbertson HK. Prevention of steroid-induced osteoporosis with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD). Lancet 1988; i:143–7.

    Google Scholar 

  21. Adams PH, Jowsey J, Kelly PJ, Riggs BL, Kinney VR, Jones JD. Effect of hyperthyroidism on bone and mineral metabolism. Q J Med 1967; 36:1–15.

    CAS  Google Scholar 

  22. Nordin BEC, Crilly RG, Smith DA. Osteoporosis. In: Nordin BEC, ed. Metabolic bone and stone disease. Edinburgh: Churchill Livingstone, 1984; 1–70.

    Google Scholar 

  23. Smith DA, Fraser SA, Wilson GM. Hyperthyroidism and calcium metabolism. Clin Endocrinol Metab 1973; 2:333–54.

    Article  PubMed  CAS  Google Scholar 

  24. Francis RM, Peacock M. The pathogenesis of osteoporosis in thyrotoxicosis. In: Christiansen C, Johansen HS, Riis BJ, eds. Osteoporosis 1987. Copenhagen: Osteopress ApS, 1987; 166–7.

    Google Scholar 

  25. Adams P, Chalmers TM, Riggs BL, Jones JD. Parathyroid function in spontaneous hypothyroidism. J Endocrinol 1968; 40:467–75.

    Article  PubMed  CAS  Google Scholar 

  26. McDermott M, Kidd GS, Blue P, Ghaed V, Hofeld FD. Reduced bone mineral content in totally thyroidectomised patients: possible effects of cacitonin deficiency. J Clin Endocrinol Metab 1983; 56:936–9.

    Article  PubMed  CAS  Google Scholar 

  27. Zapf, J, Schmidt CH, Froesch ER. Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin Endocrinol Metab 1984; 13:3–30.

    Article  PubMed  CAS  Google Scholar 

  28. Pond H. Some aspects of growth in diabetic children. Postgrad Med J 1970; 46(suppl):616–23.

    PubMed  Google Scholar 

  29. McNair P, Christiansen C, Christensen MS et al. Development of bone mineral loss in insulin treated diabetes; a 12 year follow up study in 60 patients. Eur J Clin Invest 1981; 11:55–9.

    Article  PubMed  CAS  Google Scholar 

  30. Selby PL, Marshall SM. Hydroxyproline excretion is increased in diabetes mellitus. Bone (in press) (abstract)

    Google Scholar 

  31. Selby PL, Osteopenia and diabetes. Diabetic Med 1988; 5:423–8.

    Article  PubMed  CAS  Google Scholar 

  32. Daughaday WH. The anterior pituitary. In: Wilson JD, Foster DW, eds. Williams textbook of endocrinology. Philadelphia: WB Saunders, 1981; 568–613.

    Google Scholar 

  33. Albright F, Smith PH, Richelson AM. Postmenopausal osteoporosis: its clinical features. JAMA, 1941; 116:2465–74.

    Article  Google Scholar 

  34. Albright F. Hormones and human osteogenesis. Rec Prog Horm Res 1947; 1:293–353.

    PubMed  CAS  Google Scholar 

  35. Nutik G, Cruess RL. Estrogen receptors in bone: an evaluation of the uptake of estrogen into bone cells. Proc Soc Exp Biol Med 1974; 146:265–8.

    PubMed  CAS  Google Scholar 

  36. Liskova, M. Influence of estrogens on bone resorption in organ culture. Calcif Tissue Res 1976; 22:207–18.

    Article  PubMed  CAS  Google Scholar 

  37. Van Paasen HC, Poortman J, Bogart-Creutzburg JHH, Duursma SA. Oestrogen binding proteins in bone cell cytosol. Calcif Tissue Res 1978; 25:249–54.

    Article  Google Scholar 

  38. Chen TL, Feldman D. Distinction between alfa-fetoprotein and intracellular oestrogen receptors: evidence against the presence of estradiol receptors in rat bone. Endocrinology 1978; 102:236–44.

    Article  PubMed  CAS  Google Scholar 

  39. Selby PL. Oestrogen and bone. In: Francis RM, ed. Osteoporosis pathogenesis and management. Lancaster: Kluwer, 1990; 81–101.

    Google Scholar 

  40. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Speisberg TC, Riggs BL. Evidence of estrogen receptors in normal human osteoblast cells. Science 1988; 241:84–6.

    Article  PubMed  CAS  Google Scholar 

  41. Komm BS, Terpening CM, Benz DJ et al. Estrogen binding, receptor mRNA, and biologic response in osteoblast like osteosarcoma cells. Science 1988; 241:81–4.

    Article  PubMed  CAS  Google Scholar 

  42. Gray TK, Flynn TC, Gray KM, Nabell LM. 17ß-estradiol acts directly on the clonal osteoblast line UMR 106. Proc Natl Acad Sci 1987; 184:6267–71.

    Article  Google Scholar 

  43. Ernst M, Schmid C, Froesch ER. Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci 1988; 85:2307–10.

    Article  PubMed  Google Scholar 

  44. Rodan GA, Martin TJ. Role of osteoblasts in the hormonal control of bone resorption — a hypothesis. Calcif Tissue Int 1981; 33:349–51.

    Article  PubMed  CAS  Google Scholar 

  45. Braidman IP, Anderson DC, Jones CJP, Weiss JB. Separation of two bone cell populations from fetal rat calvaria and a study of their responses to parathyroid hormone and calcitonin. J Endocrinol 1983; 99:387–99.

    Article  PubMed  CAS  Google Scholar 

  46. McSheehy PMJ, Chambers TJ. Osteoblastic cells mediate osteclastic responsiveness to parathyroid hormone. Endocrinology 1986; 118:824–8.

    Article  PubMed  CAS  Google Scholar 

  47. Frost HM. Bone remodelling and its relationship to metabolic bone diseases. Springfield, Illinois: Charles C Thomas, 1973.

    Google Scholar 

  48. Selby PL, Peacock M, Barkworth SA, Brown WB, Taylor GA. Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium regulating hormones. Clin Sci 1985; 69:265–71.

    PubMed  CAS  Google Scholar 

  49. Preger L, Steinbach HL, Moskovitch P. Roentgenographic abnormalities in phenotypic females with gonadal dysgenesis. AJR 1968; 104:899–910.

    CAS  Google Scholar 

  50. Klibanski A, Neer RM, Beitins IZ, Ridgway EC, Zervas NT, McArthur JW. Decreased bone density in hyperprolactinaemic women. N Engl J Med 1980; 303:1511–14.

    Article  PubMed  CAS  Google Scholar 

  51. Schlecte JA, Sherman B, Martin, R. Bone density in amenorrheic women with and without hyperprolactinaemia. J Clin Endocrinol Metab 1983; 56:1120–3.

    Article  Google Scholar 

  52. Koppelman MC, Kurtz DW, Morrish KA, Bou E, Susser JK, Shapiro JR, Loriaux DL. Vertebral body bone mineral content in hyperprolactinaemic women. J Clin Endocrinol Metab 1984;59:1050–3.

    Article  PubMed  CAS  Google Scholar 

  53. Cann CE, Martin WC, Genant HK, Jaffe RB. Decreased spinal mineral content in amenorrheic women. JAMA 1984; 251:626–9.

    Article  PubMed  CAS  Google Scholar 

  54. Klibanski A, Greenspan SL. Increase in bone mass after treatment of hyperprolactinemic amenorrhea. N Engl J Med 1986; 315:542–6.

    Article  PubMed  CAS  Google Scholar 

  55. Ciccarelli E, Savino L, Carlevetto V, Bertagna A, Isaia GC, Camanni I. Vertebral bone density in non-amenorrhoeic hyperprolactinaemic women. Clin Endocrinol 1988; 28:1–6.

    Article  CAS  Google Scholar 

  56. Klibanski A, Biller BKM, Rosethal DI, Schoenfeld DA, Saxe V. Effects of prolactin and estrogen deficiency in amenorrheic bone loss. J Clin Endocrinol Metab 1988; 67:124–30.

    Article  PubMed  CAS  Google Scholar 

  57. Drinkwater BL, Nilson K, Chesnut CH, Bremner WJ, Shainholtz S, Southworth MB. Bone mineral density of amenorrheic and eumenorrheic athletes. N Engl J Med 1984; 311:277–81.

    Article  PubMed  CAS  Google Scholar 

  58. Lindberg JS, Fears WB, Hunt MM, Powell MR, Boll D, Wade CE. Exercise induced amenorrhea and bone density. Ann Intern Med 1984; 101:647–8.

    PubMed  Google Scholar 

  59. Nelson ME, Fisher EC, Catsos PD, Meredith CN, Turksoy RN, Evans WJ. Diet and bone status in amenorrhoeic runners. Am J Clin Nutr 1986; 43:910–16.

    PubMed  CAS  Google Scholar 

  60. Heath H. Athletic women, amenorrhea and skeletal integrity. Ann Intern Med 1985; 102:258–60.

    PubMed  Google Scholar 

  61. Riggs BL. Eastell R. Exercise, hypogonadism and osteopenia. JAMA 1986; 256:392–3.

    Article  PubMed  CAS  Google Scholar 

  62. Rigotti NA, Nussbaum SR, Herzog DB, Neer RM. Osteoporosis in women with anorexia nervosa. N Engl J Med 1984; 311:1601–6.

    Article  PubMed  CAS  Google Scholar 

  63. Szmukler GI, Brown SW, Parsons V, Darby A. Premature loss of bone in chroic anorexia nervosa. Br Med J 1985; 290:26–7.

    Article  CAS  Google Scholar 

  64. Matta WH, Shaw RW, Hesp R, Katz D. hypogonadism induced by luteinising hormone agonist analogues: effects on bone density in premenopausal women. Br Med J. 1987; 294:1523–4.

    Article  CAS  Google Scholar 

  65. Johansen JS, Riis BJ, Hassager C, Moen M, Jacobson J, Christiansen C. The effect of a gonadotropin releasing hormone agonist analog (Nafarelin) on bone metabolism. J Clin Endocrinol Metab 1988; 67:701–6.

    Article  PubMed  CAS  Google Scholar 

  66. Jackson WU. Osteoporosis of unknown cause in younger people. J Bone Jt Surg 1958; 40B:420–41.

    Google Scholar 

  67. Francis RM, Peacock M, Aaron JE et al. Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption and low bone formation. Bone 1986; 7:261–8.

    Article  PubMed  CAS  Google Scholar 

  68. Jackson JA, Kleerekoper M, Parfitt AM. Symptomatic osteoporosis in a man with hyperprolactinaemic hypogonadism. Ann Intern Med 1986; 105:543–5.

    PubMed  CAS  Google Scholar 

  69. Greenspan SL, Neer RM, Ridgway EC, Klibanski A. Osteoporosis in men with hyperprolactinaemic hypogonadism. Ann Intern Med 1986; 104:777–82.

    PubMed  CAS  Google Scholar 

  70. Crilly RG, Francis RM, Nordin BEC. Steroid hormones, ageing and bone. Clin Endocrinol Metab 1981; 10:115–39.

    Article  PubMed  CAS  Google Scholar 

  71. Studd JWW, Savvas M, Johnson M. Correction of corticosteroid-induced osteoporosis by percutaneous hormone implants (Letter). Lancet 1989; i:339.

    Google Scholar 

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© 1990 Springer-Verlag London Limited

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Selby, P.L. (1990). Endocrinology and Osteoporosis. In: Drife, J.O., Studd, J.W.W. (eds) HRT and Osteoporosis. Springer, London. https://doi.org/10.1007/978-1-4471-1799-5_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1799-5_10

  • Publisher Name: Springer, London

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