Human T Lymphotropic Retroviruses: Pathological Consequences of Infection

  • R. C. Gallo
Part of the Argenteuil Symposia book series (ARGENTEUIL)


This volume focuses on microbes that cause disease but not by an infectious process, meaning that the effects of the microbe are very delayed, indirect, or both. Strictly speaking, the microbe is infectious but when the disease presents itself the microbe is not present or “inactive”. I will describe microbes which fit the general theme but not precisely, because during disease the microbe may still be transmitted (hence “infectious”) albeit often with difficulty and not in the acute fashion we usually think of an infectious process.


Spindle Cell Human Immune Deficiency Virus Tropical Spastic Paraparesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, Gallo RC (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596–601PubMedCrossRefGoogle Scholar
  2. 2.
    Gallo RC (1987) The AIDS virus. Sci Am 256: 47–56Google Scholar
  3. 3.
    Gallo RE, Montagnier L (1988) AIDS in 1988. Sci Am 259: 41–48PubMedCrossRefGoogle Scholar
  4. 4.
    Gallo RC (1986) The first human retrovirus. Sci Am 255: 88–98PubMedCrossRefGoogle Scholar
  5. 5.
    Blattner WA (1989) Retroviruses. In: Evans AS (ed) Viral Infections of Humans, 3rd edn. Plenum, New York, pp 545–592CrossRefGoogle Scholar
  6. 6.
    Weinhold KJ, Matthews TJ, Ahearne PM, Langlois AJ, Lyerly HK, Tyles DS, Stine KC, Durack DT, Bolognesi DP (1988) Cellular anti-gpl20 cytolytic reactivities in HTV-1 seropositive individuals. Lancet i: 902–904Google Scholar
  7. 7.
    Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, Reinherz EL (1988) Analysis of host-virus interactions in AIDS with human T cell clones specific for HTV gpl20: effect of HTV genomic heterogeneity and a mechanism for CD4+ cell depletion. Cell 54: 561–575PubMedCrossRefGoogle Scholar
  8. 8.
    Lusso P, Ensoli B, Markham PD, Ablashi DV, Salahuddin SZ, Tschachler E, Wong-Staal F, Gallo RC (1989) Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337: 370–373PubMedCrossRefGoogle Scholar
  9. 9.
    Nakamura S, Salahuddin SZ, Biberfeld P, Ensoli B, Markham PD, Wong-Staal F, Gallo RC (1988) Kaposi’s sarcoma cells: Long-term culture with growth factor from retroviras-infected CD4+ T cells. Science 242: 426–430PubMedCrossRefGoogle Scholar
  10. 10.
    Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, Wong-Staal F, Gallo RC (1989) AIDS-Kaposi’s sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 243: 223–226PubMedCrossRefGoogle Scholar

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© Springer-Verlag London Limited 1990

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  • R. C. Gallo

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