Abstract
The function of the immune system is to gather information about macromolecules entering the individual’s biological environment and to deploy various attack mechanisms when the macromolecules signify a threat to the integrity of the body. This function occurs naturally when the immune system responds to an invading bacterium or virus; it occurs iatrogenically when the individual is vaccinated with a microbial product or transplanted with a foreign tissue graft; and it occurs pathologically in autoimmune disease when the immune system turns against a normal constituent of the body as if it were a foreign menace. To avoid autoimmune disease, therefore, the immune system must be able to sort out the foreign from the self; it must be able to make decisions based on the molecular information it has gathered.
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Cohen, I.R. (1990). A Heat Shock Protein, Molecular Mimicry and Autoimmunity. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_14
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DOI: https://doi.org/10.1007/978-1-4471-1796-4_14
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