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The Role of Micro-organisms in Non-infectious Diseases pp 155–165Cite as

Molecular Mimicry in Autoimmune Disease

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Abstract

The basis for a functional immune system is the ability to discriminate between self and non-self. To this end the immune system features a set of unique recognition molecules, the major histocompatibility complex (MHC) molecules of antigen presenting cells, the immunoglobulins of B lymphocytes and the T cell receptors of T lymphocytes. Within this system, a nearly unlimited number of foreign antigens can be recognized, even structures to which the organism has not previously been exposed, yet the organism’s own molecules are not recognized. The selective lack of recognition of self antigens is believed to evolve during the maturation of T cells in the thymus [1].

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  1. T. Dyrberg
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Editors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital, 2333 AA, Leiden, The Netherlands

    René R. P. de Vries  & Jon J. van Rood  & 

  2. Department of Cell Biology, The Weizmann Institute of Science, PO Box 26, 76 100, Rehovot, Israel

    Irun R. Cohen

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Dyrberg, T. (1990). Molecular Mimicry in Autoimmune Disease. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_13

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  • DOI: https://doi.org/10.1007/978-1-4471-1796-4_13

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