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The Role of Micro-organisms in Non-infectious Diseases pp 123–130Cite as

What are the Immunogens That Incite the Autoantibodies of Systemic Lupus Erythematosus

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Part of the book series: Argenteuil Symposia ((ARGENTEUIL))

Abstract

A major problem in the field of autoimmunity is the identification of immunogens reponsible for the production of pathogenic autoantibodies. Lack of knowledge of diseaseprovoking immunogens is a serious impediment to the development of specific means of preventing and treating autoimmune disorders. In systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes and multiple sclerosis, some of the principal autoimmune diseases, the aetiological immunogen is unknown. Advances in the molecular characterization of autoantigens, mainly by using autoantibodies to identify cDNA clones of autoantigens (reviewed in [1]) have been substantial, but whether those cloned antigens can instigate pathogenic autoimmune mechanisms is unknown.

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Authors
  1. T. Koizumi
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  2. A. Puccetti
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  3. J. André-Schwartz
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  4. K. Barrett
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  5. R. S. Schwartz
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Editor information

Editors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital, 2333 AA, Leiden, The Netherlands

    René R. P. de Vries  & Jon J. van Rood  & 

  2. Department of Cell Biology, The Weizmann Institute of Science, PO Box 26, 76 100, Rehovot, Israel

    Irun R. Cohen

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© 1990 Springer-Verlag London Limited

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Koizumi, T., Puccetti, A., André-Schwartz, J., Barrett, K., Schwartz, R.S. (1990). What are the Immunogens That Incite the Autoantibodies of Systemic Lupus Erythematosus. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_11

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  • DOI: https://doi.org/10.1007/978-1-4471-1796-4_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1798-8

  • Online ISBN: 978-1-4471-1796-4

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