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Has Iron Deficiency Been Shown to Cause Altered Behavior in Infants?

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Brain, Behaviour, and Iron in the Infant Diet

Abstract

Infancy is an especially important age at which to study behavioral effects of iron deficiency. Animal studies indicate that iron deficiency during early development has more lasting effects than similar deficiency during adulthood; neurotransmitter changes, decreases in brain iron content, and behavioral alterations seem to persist despite treatment when iron deficiency anemia occurs in the infant rat, but not in the adult [1]. In the human, iron deficiency is most prevalent among (-24-month-old infants, coinciding with the latter part of the brain growth spurt and with the unfolding of fundamental mental and motor processes [2]. In view of the potential clinical significance, a number of recent studies have focused on the behavior and development of iron-deficient infants. This critical review of the several studies addresses two questions, concentrating primarily on the first and touching briefly on the second:

  1. 1.

    Has iron deficiency been proven to cause behavioral alterations in infants?

  2. 2.

    How do the results of studies of iron-deficient infants relate to those in research on other conditions in infancy that are considered to affect behavior and development adversely?

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References

  1. Lozoff B (1988) Behavioral alterations in iron deficiency. Adv Pediatr 35: 331–360

    PubMed  CAS  Google Scholar 

  2. Dobbing J (1982) The later development of the brain and its vulnerability. In: Davis JA, Dobbing J (eds) Scientific foundations of pediatrics. University Park, Baltimore, pp 744–759

    Google Scholar 

  3. Kenny DA (1979) Correlation and causality. John Wiley, New York

    Google Scholar 

  4. Bayley N (1969) Bayley scales of infant development manual. Psychological Corporation, New York

    Google Scholar 

  5. Lozoff B, Brittenham GM, Viteri FE et al. (1982) The effects of short-term oral iron therapy on developmental deficits in iron deficient anemic infants. J Pediatr 100: 351–357

    Article  PubMed  CAS  Google Scholar 

  6. Lozoff B, Brittenham GM, Viteri FE et al. (1982) Developmental deficits in iron-deficient infants: Effects of age and severity of iron lack. J Pediatr 101: 948–952

    Article  PubMed  CAS  Google Scholar 

  7. Walter T, Kowalskys J, Stekel A (1983) Effect of mild iron deficiency on infant mental development scores. J Pediatr 102: 519–522

    Article  PubMed  CAS  Google Scholar 

  8. Grindulis H, Scott PH, Belton NR et al. (1986) Combined deficiency of iron and vitamin D in Asian toddlers. Arch Dis Child 61: 843–848

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  9. Oski FA, Honig AS, Helu B et al. (1983) Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics 71: 877–880

    PubMed  CAS  Google Scholar 

  10. Johnson DL, McGowan RJ (1983) Anemia and infant behavior. Nutr Behav 1: 185–192

    Google Scholar 

  11. Deinard A, Gilbert A, Dodds M et al. (1981) Iron deficiency and behavioral deficits. Pediatrics 68: 828–833

    Google Scholar 

  12. Lozoff B, Brittenham GM, Wolf AW et al. (1987) Iron-deficiency anemia and iron therapy: Effects on infant developmental test performance. Pediatrics 79: 981–995

    PubMed  CAS  Google Scholar 

  13. Walter T, DeAndraca I, Chadud P et al. (in press) Adverse effect of iron-deficiency anemia on infant psychomotor development. Pediatrics

    Google Scholar 

  14. Pollitt E, Greenfield D, Leibel R (1979) Significance of Bayley Scale score changes following iron therapy. II. Infant Behav Dev 2: 235–238

    Article  Google Scholar 

  15. Honig AS, Oski FA (1979) Reply to Pollitt et al. Infant Behav Dev 2: 239–240

    Article  Google Scholar 

  16. Wolf AW, Lozoff B (1985) A clinically interpretable method for analyzing the Bayley Infant Behavior Record. J Pediatr Psychol 10: 199–214

    Article  PubMed  CAS  Google Scholar 

  17. Lozoff B, Brittenham G, Viteri FE et al. (1982) Behavioral abnormalities in infants with iron deficiency anemia. In: Pollitt E, Leibel RL (eds) Iron deficiency: brain biochemistry and behavior. Raven Press, New York, pp 183–194

    Google Scholar 

  18. Lozoff B, Wolf AW, Urrutia JJ et al. (1985) Abnormal behavior and low developmental test scores in iron-deficient anemic infants. J Dev Behav Pediatr 6: 69–75

    PubMed  CAS  Google Scholar 

  19. Lozoff B, Klein NK, Prabucki KM (1986) Iron-deficient anemic infants at play. J Dev Behav Pediatr 7: 152–158

    PubMed  CAS  Google Scholar 

  20. Lozoff B, Klein N, McClish D, Jimenez E (1989) Motor test behavior of anemic infants (abstr). Soc Res Child Dev 6: 150

    Google Scholar 

  21. Oski FA, Honig AS (1978) The effects of therapy on the developmental scores of iron-deficient infants. J Pediatr 92: 21–25

    Article  PubMed  CAS  Google Scholar 

  22. Honig AS, Oski FA (1978) Developmental scores of iron-deficient infants and the effects of therapy. Infant Behav Dev 1: 168–176

    Article  Google Scholar 

  23. Honig AS, Oski FA (1984) Solemnity: a clinical risk index for iron-deficient infants. Early Child Dev Care 16: 6984

    Google Scholar 

  24. Aukett MA, Parks YA, Scott PH et al. (1986) Treatment with iron increases weight gain and psychomotor development. Arch Dis Child 61: 849–857

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  25. Kopp CB, McCall RB (1982) Predicting later mental performance for normal, at-risk, and handicapped infants. Life-Span Dev Behav 4: 33–61

    Google Scholar 

  26. McCall RB (1979) The development of intellectual functioning in infancy and the prediction of later IQ. In: Osofsky JD (ed) Handbook, of infant development. Wiley, New York, pp 707–741

    Google Scholar 

  27. Lozoff B, Jimenez E, Wolf A, Klein N (1989) Long-term effect of iron-deficiency anemia in infancy ( Abstr ). Ped Res 16A: 84

    Google Scholar 

  28. Palti H, Pevsner B, Adler B (1983) Does anemia in infancy affect achievement on developmental and intelligence tests? Hum Biol 55: 189–194

    Google Scholar 

  29. Palti H, Meijer A, Adler B (1985) Learning achievement and behavior at school of anemic and non-anemic infants. Early Hum Dev 10: 217–223

    Article  PubMed  CAS  Google Scholar 

  30. Heywood A, Oppenheimer S, Heywood P, Jolley D (1989) Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea. Am J Clin Nutr [Suppl: International conference on iron deficiency and behavioral development] 50: 630–640

    CAS  Google Scholar 

  31. Life Sciences Research Office (1984) Assessment of the iron nutritional status of the US population based on data collected in the second national health and nutrition examination survey, 1976–1980. Federation of American Societies for Experimental Biology, Bethesda, MD

    Google Scholar 

  32. Levitsky DA (ed) (1979) Malnutrition, environment, and behavior. Cornell University Press, Ithaca and London

    Google Scholar 

  33. David JM, Svendsgaard DJ (1987) Lead and child development. Nature 329: 297–300

    Article  Google Scholar 

  34. Sinisterra L (1987) Studies on poverty, human growth and development: The Cali experience. In: Dobbing J (ed) Early nutrition and later achievement. Academic Press, London, pp 208–244

    Google Scholar 

  35. Grantham-McGregor S, Schofield W, Powell C (1987) Development of severely malnourished children who received psychosocial stimulation: six-year follow-up. Pediatrics 79: 247–254

    PubMed  CAS  Google Scholar 

  36. Dobbing J (ed) (1987) Early nutrition and later achievement. Academic Press, London

    Google Scholar 

  37. Horowitz FD (1989) Using developmental theory to guide the search for the effects of biological risk factors on the development of children. Am J Clin Nutr [Suppl: International conference on iron deficiency and behavioral development] 50: 589–597

    CAS  Google Scholar 

  38. Levitsky DA (1979) Malnutrition and the hunger to learn. In: Levitsky DA (ed) Malnutrition, environment, and behavior. Cornell University Press, Ithaca and London, pp 161–179

    Google Scholar 

  39. Salt P, Galler JR, Ramsey FC (1988) The influence of early malnutrition on subsequent behavioral development. VII. The effects of maternal depressive symptoms. J Dev Behav Pediatrics 9: 1–5

    Article  CAS  Google Scholar 

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Authors
  1. Betsy Lozoff
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Editors and Affiliations

  1. Department of Child Health, University of Manchester, Oxford Road, M13 9PT, Manchester, UK

    John Dobbing DSc, FRCP, FRCPath (Emeritus Professor of Child Growth and Development) (Emeritus Professor of Child Growth and Development)

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© 1990 Springer-Verlag London

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Lozoff, B. (1990). Has Iron Deficiency Been Shown to Cause Altered Behavior in Infants?. In: Dobbing, J. (eds) Brain, Behaviour, and Iron in the Infant Diet. Springer, London. https://doi.org/10.1007/978-1-4471-1766-7_11

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  • DOI: https://doi.org/10.1007/978-1-4471-1766-7_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1768-1

  • Online ISBN: 978-1-4471-1766-7

  • eBook Packages: Springer Book Archive

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