Organization, Structure and Expression of Pentraxin Genes
The acute phase response is a systemic reaction to an inflammatory stimulus (such as burns, surgery, infection or tissue trauma) and is characterized by a spectrum of physiological changes. Alterations in hormone and electrolyte levels, nitrogen balance and the concentrations of a wide range of serum proteins are readily observed. Quantitatively, the most dramatic change is the increase by up to a thousand-fold in the serum concentration of a limited number of acute phase proteins. In man, these are C-reactive protein (CRP) and serum amyloid A component (SAA). The CRP analogue, serum amyloid P component (SAP), is not an acute phase protein in man, though in the mouse it is.
KeywordsAcute Phase Protein Acute Phase Response Serum Amyloid Chloramphenicol Acetyl Transferase Heat Shock Gene
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- Kushner I, Volanakis JE, Gewurz H (Eds) (1982) C-reactive protein and the plasma protein response to tissue injury. Ann NY Acad Sci 389Google Scholar
- Lalley PA, O’Brien SJ, Creau-Goldberg N, Davisson MT, Roderick TH, Echard G, Womack JE, Graves JM, Doolittle DP, Guidi JN (1988) Report of the committee on comparative mapping. Cytogenet Cell Genet 47: 364–389Google Scholar
- Lei K-J, Liu T, Zon G, Soravia E, Liu T-Y, Goldman ND (1985) Genomic DNA sequence for human C-reactive protein. J Biol Chem 160: 13377–13383Google Scholar
- Oliviera EB, Gotschlich, EC, Liu T-Y (1979) Primary structure of human C-reactive protein. J Biol Chem 254: 489–502Google Scholar