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Organization, Structure and Expression of Pentraxin Genes

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Acute Phase Proteins in the Acute Phase Response

Part of the book series: Argenteuil Symposia ((ARGENTEUIL))

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Abstract

The acute phase response is a systemic reaction to an inflammatory stimulus (such as burns, surgery, infection or tissue trauma) and is characterized by a spectrum of physiological changes. Alterations in hormone and electrolyte levels, nitrogen balance and the concentrations of a wide range of serum proteins are readily observed. Quantitatively, the most dramatic change is the increase by up to a thousand-fold in the serum concentration of a limited number of acute phase proteins. In man, these are C-reactive protein (CRP) and serum amyloid A component (SAA). The CRP analogue, serum amyloid P component (SAP), is not an acute phase protein in man, though in the mouse it is.

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Authors
  1. A. S. Whitehead
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Editors and Affiliations

  1. Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK

    M. B. Pepys MA, MD, PhD, FRCP, MCRPath

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© 1989 Springer-Verlag London Limited

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Whitehead, A.S. (1989). Organization, Structure and Expression of Pentraxin Genes. In: Pepys, M.B. (eds) Acute Phase Proteins in the Acute Phase Response. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1739-1_4

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  • DOI: https://doi.org/10.1007/978-1-4471-1739-1_4

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1741-4

  • Online ISBN: 978-1-4471-1739-1

  • eBook Packages: Springer Book Archive

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