Organization, Structure and Expression of Pentraxin Genes
The acute phase response is a systemic reaction to an inflammatory stimulus (such as burns, surgery, infection or tissue trauma) and is characterized by a spectrum of physiological changes. Alterations in hormone and electrolyte levels, nitrogen balance and the concentrations of a wide range of serum proteins are readily observed. Quantitatively, the most dramatic change is the increase by up to a thousand-fold in the serum concentration of a limited number of acute phase proteins. In man, these are C-reactive protein (CRP) and serum amyloid A component (SAA). The CRP analogue, serum amyloid P component (SAP), is not an acute phase protein in man, though in the mouse it is.
KeywordsArthritis Codon Recombination Pneumonia Methionine
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