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Experimental Findings in Radiation Bowel Disease

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The Causation and Clinical Management of Pelvic Radiation Disease

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Abstract

The pathological response of the bowel to radiation is complex, but histological changes in small vessels are commonly found in radiation damaged bowel (Berthrong and Fajardo 1981). It has been postulated that these vascular lesions may compromise the microvasculature of the bowel and lead to progressive ischaemia (Ashbaugh and Owens 1963; DeCosse et al. 1969). Although there is evidence from studies in experimental animals to support this hypothesis (Eddy and Casarett 1968; Eriksson 1982) the role of small-vessel disease in the pathogenesis of human radiation bowel disease (RBD) remains unclear.

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Authors
  1. N. D. Carr
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  2. D. Holden
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Editor information

Editors and Affiliations

  1. University of Manchester, University Hospital of South Manchester, Manchester, M20 8LR, UK

    P. F. Schofield MD, FRCS (Honorary Reader in Surgery, Consultant Surgeon) (Honorary Reader in Surgery, Consultant Surgeon)

  2. University Hospital of South Manchester, Manchester, M20 8LR, UK

    E. W. Lupton MD, FRCS (Consultant Urologist) (Consultant Urologist)

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© 1989 Springer-Verlag Berlin Heidelberg

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Carr, N.D., Holden, D. (1989). Experimental Findings in Radiation Bowel Disease. In: Schofield, P.F., Lupton, E.W. (eds) The Causation and Clinical Management of Pelvic Radiation Disease. Springer, London. https://doi.org/10.1007/978-1-4471-1704-9_5

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  • DOI: https://doi.org/10.1007/978-1-4471-1704-9_5

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1706-3

  • Online ISBN: 978-1-4471-1704-9

  • eBook Packages: Springer Book Archive

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