The Role of the Gut Microflora in the Digestion of Starches and Sugars: With Special Reference to Their Role in the Metabolism of the Host, Including Energy and Vitamin Metabolism

  • D. A. T. Southgate
Part of the ILSI Human Nutrition Reviews book series (ILSI HUMAN)


In the context of the conventional descriptions of the digestion of the sugars and starches in foods, the role of the microflora is regarded as a minor scavenging one, and one that moreover operates only under exceptional, usually pathological conditions[1]. The small-intestinal digestion and absorption of these food carbohydrates is assumed to be virtually complete, and the interaction of the microflora with the undigested components of the plant cell wall (dietary fibre) is assumed to be quantitatively of much greater importance.


Dietary Fibre Short Chain Fatty Acid Resistant Starch Sugar Alcohol Glucose Syrup 
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  1. 1.
    FAO (1980) Carbohydrates in human nutrition. Food and Agriculture Organisation of the United Nations, Rome (Food and nutrition paper 15 )Google Scholar
  2. 2.
    Englyst HN, Cummings JH (1987) Resistant starch, a “new” food component: a classification of starch for nutritional purposes. In: Morton ID (ed) Cereals in a European context. Ellis Horwood, Chichester, pp 221–223Google Scholar
  3. 3.
    Metz G, Gassull MA, Drasar BS, Jenkins DJA, Blendis LM (1976) Breath hydrogen test for small intestinal bacterial colonisation. Lancet I: 668–669CrossRefGoogle Scholar
  4. 4.
    Southgate DAT (1976) Determination of food carbohydrates. Applied Science Publishers, LondonGoogle Scholar
  5. 5.
    Greenfield H, Southgate DAT (1989) Guidelines for the production management and use of food composition data. United Nations University (in press)Google Scholar
  6. 6.
    Southgate DAT, Paul AA, Dean AC, Christie AA (1978) Free sugars in foods. J Hum Nutr 32: 335–347PubMedGoogle Scholar
  7. 7.
    Banks W, Greenwood CT (1975) Starch and its components. Edinburgh University Press, EdinburghGoogle Scholar
  8. 8.
    Pigman WW, Goepp RM (1948) Chemistry of carbohydrates. Academic Press, New York, pp 582–594Google Scholar
  9. 9.
    Englyst FIN, Anderson V, Cummings JH (1983) Starch and non-starch polysaccharides in some cereal foods, J Sci Food Agric 34: 1439–1440CrossRefGoogle Scholar
  10. 10.
    Stephen AM, Cummings JH (1980) The microbial contribution to human faecal mass. J Med Microbiol 13: 45–56PubMedCrossRefGoogle Scholar
  11. 11.
    Englyst HJN (1985) Dietary polysaccharide breakdown in the gut of man. PhD thesis, University of CambridgeGoogle Scholar
  12. 12.
    Crawford C (1987) Survey of resistant starch in processed foods. Bulletin of the Flour Milling and Baking Research Association 2: 59–64Google Scholar
  13. 13.
    Bingham SA, Williams DRR, Cummings JH (1985) Dietary fibre consumption in Britain: new estimates and their relation to large bowel cancer mortality. Br J Cancer 52: 399–402PubMedCrossRefGoogle Scholar
  14. 14.
    Southgate DAT, Bingham S, Robertson J (1978) Dietary fibre in the British diet. Nature 274: 51–52PubMedCrossRefGoogle Scholar
  15. 15.
    Drasar BS, Hill MJ (1974) Human intestinal flora. Academic Press, LondonGoogle Scholar
  16. 16.
    Hungate RE (1966) The rumen and its microbes. Academic Press, New YorkGoogle Scholar
  17. 17.
    Curzon MEJ (1988) Dietary carbohydrate and dental caries. In: Dobbing J (ed) A balanced diet? Springer-Verlag, Berlin Heidelberg New York, pp 57–74Google Scholar
  18. 18.
    Moore WEC (1978) Some current concepts in intestinal bacteriology. Am J Clin Nutr 31: S33 - S42PubMedGoogle Scholar
  19. 19.
    Barnside GH (1978) Stability of human fecal flora. Am J Clin Nutr 31: S141 - S144Google Scholar
  20. 20.
    Cummings JH (1981) Dietary fibre. Br Med Bull 37: 65–70Google Scholar
  21. 21.
    Miller TL, Wolin MJ (1979) Fermentation by saccharolytic intestinal bacteria Am J Clin Nutr 32: 144–172Google Scholar
  22. 22.
    Salyers AA, Palmer JK, Wilkins TD (1978) Degradation of polysaccharides by intestinal enzymes. Am J Clin Nutr 31: S128–130PubMedGoogle Scholar
  23. 23.
    Taeuful K, Ruttloff H, Krause W, Taeuful A, Vetter K (1965) Zum intestinen Verhalten von Galakto-oligasacchariden beim Menschen. Klin Wochenschr 43: 268–272CrossRefGoogle Scholar
  24. 24.
    Cristafaro E, Mottu F, Wuhrmann JS (1974) Involvement of raffinose family of oligosaccharides in flatulence. In: Sipple HL, McNutt CW (eds) Sugars in nutrition. Academic Press, New York, pp 313–336Google Scholar
  25. 25.
    Caspary WF, Lembcke B, Elsenhans B (1981) Bacterial fermentation of carbohydrates within the gastrointestinal tract. In: Read NW (ed) Diarrhoea: new insights. Clin Res Rev 1: [Suppl]107–117Google Scholar
  26. 26.
    McNeil NI, Cummings JH, James WPT (1978) Short chain fatty acid absorption by the human large intestine. Gut 19: 819–822PubMedCrossRefGoogle Scholar
  27. 27.
    Ruppin H, Bar-Meir S, Soergal KH, Wood CM, Schmitt MG (1980) Absorption of short-chain fatty acids by the colon. Gastroenterology 78: 1500–1507PubMedGoogle Scholar
  28. 28.
    Dahlquist A (1974) Enzyme deficiency and malabsorption of carbohydrates. In: Sipple HL, McNutt CW (eds) Sugars in nutrition. Academic Press, New York, pp 187–214Google Scholar
  29. 29.
    Southgate DAT, Barrett IM (1966) The intake and excretion of calorific of milk by infants. Br J Nutr 20: 363–372PubMedCrossRefGoogle Scholar
  30. 30.
    György P (1974) Effects of carbohydrate on the intestinal flora. In: Sipple HL, McNutt CW (eds) Sugars in nutrition. Academic Press, New York, pp. 215–226Google Scholar
  31. 31.
    Armada F, Eisenstein A (1970) Cited by Bron and Miller, in Sipple HL, McNutt CW (eds) Sugars in nutrition. Academic Press, New York.Google Scholar
  32. 32.
    Sandberg AS, Anderson H, Hallgren B, Hasselblad K, Isaksson B, Hulten L (1981) Experimental model for in vivo determination of dietary fibre and its effects on the small bowel absorption of nutrients. Br J Nutr 45: 283–294PubMedCrossRefGoogle Scholar
  33. 33.
    Englyst HN, Cummings JH (1986) Digestion of the carbohydrate of banana (Musa paradisiaca sapientum) in the human small intestine. Am J Clin Nutr 44: 42–50PubMedGoogle Scholar
  34. 34.
    Englyst HN, Cummings JH (1987) Digestion of the polysaccharides of potato in the small intestine of man. Am J Clin Nutr 45: 423–431PubMedGoogle Scholar
  35. 35.
    Jenkins DJA, Cuff D, Wolever TMS et al. (1987) Digestibility of carbohydrate foods in ileosomate relationship to dietary fiber in vitro digestibility and glydemic response. Am J Gastroenterol 82: 709–717PubMedGoogle Scholar
  36. 36.
    Tadesse K, Eastwood MA (1978) Metabolism of dietary fibre components in man assessed by breath hydrogen and methane. Br J Nutr 40: 393–396PubMedCrossRefGoogle Scholar
  37. 37.
    Tadesse K, Smith D, Eastwood MA (1980) Breath hydrogen (H2) and methane (CH4) excretion in normal man and in clinical practice. Q J Exp Pathol 65: 85–97Google Scholar
  38. 38.
    Englyst HN, Macfarlane GT (1986) Breakdown of resistant and readily digestible starch by human gut bacteria. J Sci Food Agric 36: 699–706CrossRefGoogle Scholar
  39. 39.
    Mortensen PB, Holtug K, Rasmussen HS (1988) Short chain fatty acid production from monosaccharides and disaccharides in a faecal incubation system: implications for the colonic fermentation of dietary fiber in humans. J Nutr 118: 321–325PubMedGoogle Scholar
  40. 40.
    Shetty PS, Kurpad AV (1986) Increasing starch intake in the human diet increases fecal bulking. Am J Clin Nutr 43: 210–212PubMedGoogle Scholar
  41. 41.
    Ministry of Agriculture, Fisheries and Food (1988) Household Food Consumption and Expenditure 1986. Report of the National Food Survey Committee. Her Majesty’s Stationery Office, LondonGoogle Scholar
  42. 42.
    Stephen AM, Cummings JH (1980) Mechanism of action of dietary fibre in the human colon. Nature 284: 283–284PubMedCrossRefGoogle Scholar
  43. 43.
    Cummings JH, Stephen AM, Branch WJ (1981) Implications of dietary fiber breakdown in the human colon. Banbury Report 7: Gastrointestinal cancer: endogenous factors. Cold Spring Harbor Laboratory, New YorkGoogle Scholar
  44. 44.
    Asp NG, Johanssen GG (1984) Dietary fibre analysis. Nutr Abstr Rev 54A: 735–752Google Scholar
  45. 45.
    Berry CS (1986) Resistant starch: formation and measurement of starch that survives exhaustive digestion with amylolytic enzymes during the determination of dietary fibre. J Cereal Sci 4: 301–314CrossRefGoogle Scholar
  46. 46.
    Jenkins DJA, Jenkins AL, Wolever TMS, Thompson LH, Rao AV (1986) Simple and complex carbohydrates. Naringsforskning [Suppl] 23: 11–16Google Scholar
  47. 47.
    Bingham SA, Williams DRR, Cummings JH (1985) Dietary fibre consumption in Britain: new estimates and their relation to large bowel cancer rates. Br J Cancer 52: 399–402PubMedCrossRefGoogle Scholar
  48. 48.
    Bingham SA (1987) Definitions and intakes of dietary fiber. Am J Clin Nutr 45: 1226–1231PubMedGoogle Scholar
  49. 49.
    Southgate DAT (1988) Dietary fibre and the diseases of affluence. In: Dobbing J (ed) A balanced diet. Springer, Berlin Heidelberg New York, pp 117–139Google Scholar
  50. 50.
    Paul AA, Southgate DAT (1978) In: McCance and Widdowson’s The composition of foods, 4th edn. HMSO, LondonGoogle Scholar
  51. 51.
    Merrill AL, Watt BK (1955) Energy value of foods basis and derivation. US Department of Agriculture, Washington DC (Agriculture handbook 74 )Google Scholar
  52. 52.
    Southgate DAT, Durnin JVGA (1970) Calorie conversion factors: an experimental reassessment of the factors used in the calculation of the energy value of human diets. Br J Nutr 24: 517–535PubMedCrossRefGoogle Scholar
  53. 53.
    McCance RA, Lawrence RD (1929) The carbohydrate content of foods. (Medical Research Council Special report 135)Google Scholar
  54. 54.
    Widdowson EM (1960) Note on the calculation of the calorific value of foods and diets. In: McCance RA, Widdowson EM The composition of foods, 3rd edn. HMSO, London, pp 153–159Google Scholar
  55. 55.
    McCance RA, Widdowson EM, Shackleton LRB (1936) The nutritive value of fruits, vegetables and nuts. HMSO, London (Medical Research Council special report 213 )Google Scholar
  56. 56.
    Southgate DAT (1969) Determination of carbohydrates in foods. II. Unavailable carbohydrates. J Sci Food Agric 20: 331–335PubMedCrossRefGoogle Scholar
  57. 57.
    Southgate DAT, Bailey B, Collinson E, Walker AF (1976) A guide to calculating dietary fibre intakes. J Hum Nutr 30: 303–313PubMedGoogle Scholar
  58. 58.
    Southgate DAT (1971) Assessing the energy value of the human diet. Nutr Rev 29: 131–134PubMedCrossRefGoogle Scholar
  59. 59.
    Southgate DAT (1975) Fibre and other unavailable carbohydrates and energy effects in the diet. Proceedings of the 4th Western Hemisphere Nutrition CongressGoogle Scholar
  60. 60.
    Livesey G (1988) Energy from food — old values and new perspectives. British Nutrition Foundation, London (Nutrition bulletin 52 (13): 9–28 )Google Scholar
  61. 61.
    Stephen MA, Haddad AC, Phillips SF (1983) Passage of carbohydrate into the colon: direct measurement in humans. Gastroenterology 85: 589–595PubMedGoogle Scholar
  62. 62.
    Pomare EW, Branch WJ, Cummings JH (1985) Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J Clin Invest 75: 1448–1454PubMedCrossRefGoogle Scholar
  63. 63.
    Flourié B, Florent C, Jouany JP, Thivend P, Etanchoud F, Rambaud JC (1985) Caloric metabolism of wheat starch in healthy humans: effects on fecal outputs and clinical symptoms. Gastroenterology 90: 111–119Google Scholar
  64. 64.
    Kaspar H (1986) Effects of dietary fibre on vitamin metabolism. In: Spiller GA (ed) Handbook of dietary fibre in human nutrition. CRC Press, Boca Raton, pp 201–208Google Scholar
  65. 65.
    Anonymous (1980) Intestinal microflora, injury and vitamin K deficiency Nutr Rev 38: 341Google Scholar
  66. 66.
    Albert MJ, Mathan VJ, Baker JJ (1980) Vitamin B12 synthesis by human small intestinal bacteria. Nature: 233–781Google Scholar
  67. 67.
    Suttle JW (1984) Vitamin K. In: Machlin LJ (ed) Handbook of vitamins. Marcel Dekker, New York, pp 147–98Google Scholar
  68. 68.
    Ellenbogen L (1984) Vitamin B12. In: Machlin LJ (ed) Handbook of vitamins Marcel Dekker, New York, pp 497–547Google Scholar


  1. 1.
    Ravich WJ, Bayless TM, Thomas M (1983) Fructose: incomplete intestinal absorption in humans. Gastroenterology 84: 26–29PubMedGoogle Scholar
  2. 2.
    Hill MJ (1983) Bacterial adaptation to lactose deficiency. In: Delmont J (ed) Milk intolerance and rejection. Karger, Basel, pp 22–26Google Scholar
  3. 3.
    Florent C, Flourié B, Leblond A, Rautureau M, Bernier JJ, Rambaud JC (1985) Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man. J Clin Invest 75: 608–613PubMedCrossRefGoogle Scholar


  1. 1.
    Yajima T (1985) Contractile effect of short chain fatty acids on the isolated rat’s colon. J Physiol 368: 667–678PubMedGoogle Scholar
  2. 2.
    Yajima T (1988) Luminal propionate induced secretory response in rat distal colon in vitro. J Physiol 403: 559–575PubMedGoogle Scholar


  1. 1.
    Morgan LM, Flatt PR, Marks V (1988) Nutrient regulation of the enteroinsular axis and insulin secretion. Nutr Res Rev 1: 79–97PubMedCrossRefGoogle Scholar
  2. 2.
    Brown JC (1982) Gastric inhibitory polypeptide. Springer, Berlin Heidelberg New YorkGoogle Scholar


  1. 1.
    Makinen KK, Scheinen A (1975) Turku sugar studies. VI. The administration of the trial and the control of the dietary regimen. Acta Odont Scand 33 [Suppl 70]: 105–127Google Scholar
  2. 2.
    Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V (1985) Gut microflora interactions with xylitol in the mouse, rat and man. Fd Chem Toxic 23: 985–990CrossRefGoogle Scholar
  3. 3.
    Salminen S, Salminen E, Bridges J, Marks V (1986) The effects of sorbitol on the gastrointestinal microflora of rats. Z Emahrungswiss 25: 91–95CrossRefGoogle Scholar
  4. 4.
    Kaji H, Asanuma Y, Yahara O, Shibue H, Hisamura M, Saito N, Kawaakakawi Y, Murao M (1984) Intragastrointestinal alcohol fermentation syndrome: report of two cases and review of the literature. J Forensic Sci Soc 24: 461–471PubMedCrossRefGoogle Scholar


  1. 1.
    Flourié B, Leblond A, Florent C, Rautureau M, Bisalli A, Rambaud JC (1988) Starch malabsorption and breath gas excretion in healthy humans consuming low-and high-starch diets. Gastroenterology 95: 356–363PubMedGoogle Scholar


  1. 1.
    Vantrappen G, Jaussius J, Peeters TL (1981) The migrating motor complex. Med Clin N Am 65: 1311–1329PubMedGoogle Scholar
  2. 2.
    Vantrappen G, Jaussius J, Hellemius J, Ghoes Y (1977) The MMC of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59: 1158–1166PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

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  • D. A. T. Southgate

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