Abstract
After the first promising results of cytotoxic treatment during the 1940s there was a tremendous surge of activity to discover new anticancer agents in the hope of finding the ideal drug that would eradicate the tumour whilst having no harmful effects on normal tissue. Forty years later this hope has yet to be fulfilled, but the search for new cytotoxics has yielded many thousands of compounds with possible therapeutic applications. Somewhat less than forty of these are in common use today.
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References
Pharmacologic principles of cancer treatment. Chabner B (editor) Saunders, Philadelphia, 1982
Metabolism and action of anticancer drugs. Powis G, Prough RA (editors) Falmer Press, Philadelphia, 1986
Ifosfamide: pharmacology, safety and therapeutic potential. Brade WP, Herdrich K, Varini M (1985) Cancer Treatment Reviews, 12, 1–17
Hexamethylmelamine: a critical review of an active drug. Foster BJ, Harding BJ, Leyland-Jones B, Horth D (1986) Cancer Treatment Reviews, 13: 197–218
Epirubicin: a review of the pharmacology, clinical activity and adverse effects of an adriamycin analogue. Cersosimo RJ, Hong WK (1986) Journal of Clinical Oncology, 4: 425–439
Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans. Mross K etal (1988) Journal of Clinical Oncology, 6: 517–526
Progress in anthracycline therapy. Various authors (1987) Clinical Trials Journal, 24, Supplement 1: 1–250
Carboplatin: current status and future prospects. Canetta R, Bragman K, Smaldone L, Rosencweig M (1988) Cancer Treatment Reviews, 15: Supplement B: 17–32
Cancer chemotherapy: carboplatin v cisplatin. Anonymous (1987) Drug & Therapeutics Bulletin, 25: 67–68
Whither carboplatin? A replacement for or an alternative to cisplatin? Von Hoff D (1987) Journal of Clinical Oncology, 5:169–171
Novantrone (mitozantrone). Cotter FE (1988) The British Journal of Clinical Practice, 42: 207–209
Mitozantrone. Anonymous (1986) Drug and Therapeutics Bulletin, 24: 71–72
Mitozantrone. Nathanson L (1984) Cancer Treatment Reviews, 11: 289–301
Amsacrine (AMSA). Isell BF (1980) Cancer Treatment Reviews, 7: 73–85
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© 1989 Springer-Verlag Berlin Heidelberg
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Priestman, T.J. (1989). The Pharmacology of Cytotoxic Drugs. In: Cancer Chemotherapy: an Introduction. Springer, London. https://doi.org/10.1007/978-1-4471-1686-8_3
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DOI: https://doi.org/10.1007/978-1-4471-1686-8_3
Publisher Name: Springer, London
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