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Diabetes in Pregnancy: Genetic and Temporal Relationships of Maldevelopment in the Offspring of Diabetic Rats

  • Chapter
Carbohydrate Metabolism in Pregnancy and the Newborn · IV

Abstract

The aetiology of the dysmorphogenesis (Miller 1946; Naeye 1965; Kucera 1971) and embryo-fetal wastage (Pedersen 1977; Pedersen and Mølsted-Pedersen 1982; Sutherland and Pritchard 1986) found in the offspring of diabetic mothers is unknown (Freinkel 1980; Mills 1982). To study this problem we have used a rat model in which female rats are made manifestly diabetic with streptozotocin 1–4 weeks prior to mating with non-diabetic males (Eriksson et al. 1980). The animals are an outbred substrain of Sprague-Dawley albino rats, which was originally imported from Zentralinstitut für Versuchtiersucht (Hanover, FRG) to a Swedish commercial breeding institution in 1962 (Anticimex/ALAB, Sollentuna, Sweden). In 1982 the colony was moved to our Department in Uppsala (hence, these animals are denoted U rats) and the Swedish breeder re-imported new outbred Sprague-Dawley rats from the original colony in Hanover (called H rats in the following; see also Fig. 6.1).

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Authors
  1. U. J. Eriksson
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  2. J. Styrud
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  3. R. S. M. Eriksson
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Editor information

Editors and Affiliations

  1. Aberdeen Maternity Hospital, Foresterhill, Cornhill Road, AB9 2ZA, Aberdeen, UK

    H. W. Sutherland MBChB, FRCOG (Clinical Reader in Obstetrics and Gynaecology) (Clinical Reader in Obstetrics and Gynaecology)

  2. University of Aberdeen, 13 Westerton Road, Cults, AB1 9MR, Aberdeen, UK

    J. M. Stowers MA, MBChB, MD, FRCP, FRCOG (Emeritus Professor of Dietetics and Endocrinology) (Emeritus Professor of Dietetics and Endocrinology)

  3. Diabetic Clinic, Woolman Hill, Aberdeen Royal Infirmary, AB9 2ZB, Aberdeen, UK

    D. W. M. Pearson MBChB, MRCP (Consultant Physician) (Consultant Physician)

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© 1989 Springer-Verlag Berlin Heidelberg

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Eriksson, U.J., Styrud, J., Eriksson, R.S.M. (1989). Diabetes in Pregnancy: Genetic and Temporal Relationships of Maldevelopment in the Offspring of Diabetic Rats. In: Sutherland, H.W., Stowers, J.M., Pearson, D.W.M. (eds) Carbohydrate Metabolism in Pregnancy and the Newborn · IV. Springer, London. https://doi.org/10.1007/978-1-4471-1680-6_6

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  • DOI: https://doi.org/10.1007/978-1-4471-1680-6_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1682-0

  • Online ISBN: 978-1-4471-1680-6

  • eBook Packages: Springer Book Archive

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