Abstract
As early as 1967 attempts were made to develop radiopharmaceuticals for imaging the adrenal medulla, based upon the properties of that tissue to synthesize, store and secrete catecholamines. One approach has been to develop analogues of the hypotensive drug guanethidine, which is known to act by depletion of noradrenaline from storage granules as well as interfering with the normal catecholamine release mechanism in response to an evoked potential (Maxwell and Wastila 1977). Studies of 14C-guanethidine uptake in dogs showed that this compound has a high affinity for the adrenal medulla; however, there are no straight-forward methods for radiolabelling guanethidine with a suitable gamma-emitting isotope. Attention therefore focused on the development of guanethidine analogues which exhibited similar bio-distribution but which could be labelled for routine imaging in a nuclear medicine department.
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References
Buck J, Bruchelt G, Girgert R, et al. (1985) Specific uptake of m-[125I] iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH. Cancer Res 85:6366–6370
Gagnier B, Rosin MP, Scherman D, et al. (1986) Uptake of metaiodobenzylguanidine by bovine chromaffin granule membranes. Molec Pharmacol 29:275–280
Jaques S, Tobes MC (1985) Comparison of the secretory mechanisms of meta-iodobenzylguanidine (mIBG) and norepinephrine (NE) from cultured bovine adrenomedullary cells. J Nucl Med 26:17
Jaques S, Tobes MC, Sisson JC (1984) Comparison of the sodium dependency of uptake of meta-iodobenzylguanidine and norepinephrine into cultured bovine adrenomedullary cells. Molec Pharmacol 26:539–546
Jaques S, Tobes MC, Sisson JC (1987) Sodium dependency of uptake of norepinephrine and m-iodobenzylguanidine into cultured human pheochromocytoma cells: evidence for uptake-one. Cancer Res 47:3920–3928
Maxwell RA, Wastila WB (1977) Acute hypertensive agents. In Gross F (ed) Handbook of experimental pharmacology, Springer, Berlin, Heidelberg, New York, vol 39. p 161
Sisson JC, Shapiro B, Meyers L et al. (1987) Meta-iodobenzylguanidine to map scintigraphically the adrenergic nervous system in man. J Nucl Med 28:10
Wieland DM, Wu J-L, Brown LE et al. (1980) Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [131I]iodobenzylguanidine. J Nucl Med 21:349–353
Wieland DM, Brown LE, Tobes MC et al. (1981) Imaging the primate adrenal medullae with [123I] and [131I]meta-iodobenzylguanidme: concise communication. J Nucl Med 22:358–364
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Tyrwhitt-Drake, B.G. (1989). Chemistry and Pharmacy of mIBG. In: Neuroblastoma. Springer, London. https://doi.org/10.1007/978-1-4471-1674-5_3
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DOI: https://doi.org/10.1007/978-1-4471-1674-5_3
Publisher Name: Springer, London
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