Oocyte donation, unlike its male counterpart of sperm donation which has been a routine clinical treatment for male infertility for many years, has only become feasible since the widespread introduction of in vitro fertilization (IVF). Prior to the advent of IVF there was neither a source of oocytes for donation nor the laboratory or clinical techniques available to ensure successful fertilization and transfer of the resulting embryo. There are now several reports in the literature of successful pregnancies following oocyte donation to patients either unwilling or unable to conceive from their own oocytes (Lutjen et al. 1984; Feichtinger and Kemeter 1985; Navot et al. 1986; Rosenwaks et al. 1986; Asch et al. 1987; Serhal and Craft 1987; Devroey et al. 1987). A number of variations in the clinical use of donated oocytes now exist. These include fertilization with husband or donor semen, transfer to recipients with or without endogenous ovarian function, and more recently, the use of gamete intra-fallopian transfer (GIFT) rather than IVF (Asch et al. 1987). In addition to providing an avenue for successful pregnancy in those patients with hypergonadotrophic hypogonadism or inheritable genetic disorders, oocyte donation also provides a unique opportunity for the study and understanding of the steroid replacement parameters necessary to induce uterine receptivity, the synchronization of embryo development with uterine receptivity prior to implantation, and the endocrinology of pregnancy in the absence of ovarian function.
KeywordsEmbryo Transfer Corpus Luteum Premature Ovarian Failure Oocyte Donation Luteinizing Hormone Surge
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