Oocyte donation, unlike its male counterpart of sperm donation which has been a routine clinical treatment for male infertility for many years, has only become feasible since the widespread introduction of in vitro fertilization (IVF). Prior to the advent of IVF there was neither a source of oocytes for donation nor the laboratory or clinical techniques available to ensure successful fertilization and transfer of the resulting embryo. There are now several reports in the literature of successful pregnancies following oocyte donation to patients either unwilling or unable to conceive from their own oocytes (Lutjen et al. 1984; Feichtinger and Kemeter 1985; Navot et al. 1986; Rosenwaks et al. 1986; Asch et al. 1987; Serhal and Craft 1987; Devroey et al. 1987). A number of variations in the clinical use of donated oocytes now exist. These include fertilization with husband or donor semen, transfer to recipients with or without endogenous ovarian function, and more recently, the use of gamete intra-fallopian transfer (GIFT) rather than IVF (Asch et al. 1987). In addition to providing an avenue for successful pregnancy in those patients with hypergonadotrophic hypogonadism or inheritable genetic disorders, oocyte donation also provides a unique opportunity for the study and understanding of the steroid replacement parameters necessary to induce uterine receptivity, the synchronization of embryo development with uterine receptivity prior to implantation, and the endocrinology of pregnancy in the absence of ovarian function.
KeywordsRadium Progesterone Oestradiol Valerate Infertility
Unable to display preview. Download preview PDF.
- Allan WM, Corner GN (1930) Physiology of corpus luteum. VII. Maintenance of pregnancy in rabbit after very early castration, by corpus luteum extracts. Proc Soc Exp Biol Med 27:403–405Google Scholar
- Bigazzi M, Nardig E, Petrucci F et al. (1983) Synthesis of relaxin by human decidua. In: Bigazzi M, Greenwood FC, Gasparri F (eds) Biology of Relaxin and its Role in the Human. Excerpta Medica, Amsterdam, pp 206–212Google Scholar
- Devroey P, Smitz J, Wisanto A et al. (1987) Primary ovarian failure: embryo donation after substitution therapy. 5th world congress on IVF and ET. Norfolk, Virginia, 5–10 April (Abstract No OC-427)Google Scholar
- Hodgson YM, Averill S, Torney A, de Kretser DM (1987) A fetal source of inhibin demonstrated by in situ hybridisation. Society for the study of fertility, York (abstract 41)Google Scholar
- Leeton J, Caro C, Howlett D, Harman J (1986b). The search for donor eggs: a problem of supply and demand. J Clin Reprod Fertil 4:337–340Google Scholar
- McLachlan RI, Robertson DM, de Kretser DM, Burger HG (1987a) Inhibin — a non-steroidal regulator of pituitary follicle stimulating hormone. Clin Endocrinol Metab 1:89–112Google Scholar
- Muttram JC, Cramer W (1923) On the general effects of exposure to radium on metabolism and tumour growth in the rat and the special effects on testis and pituitary., QJ Exp Physiol 13:209–226Google Scholar
- Noyes RW, Hertig AT, Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1:3–25Google Scholar
- Psychoyos A, Casimiri V (1981) Uterine blastotoxic factors. In: Glasser SR, Bullock DW (eds) Cellular and molecular aspects of implantation. Plenum Press, New York, pp 327–334Google Scholar
- Rogers PAW, Macpherson A, Beaton L (1988) Embryo implantation in the anterior chamber of the eye: effects on uterine allografts and the microvasculature. Ann NY Acad Sci (in Press)Google Scholar
- Szalachter N, O’Bryne E, Goldsmith L et al. (1980) Myometrial inhibiting activity of relaxincontaining extracts of human corpora lutea of pregnancy. Am J Obstet Gynecol 136:584–589Google Scholar