Oocyte Donation

  • P. A. W. Rogers
  • J. Leeton
  • I. T. Cameron
  • C. Murphy
  • D. L. Healy
  • P. Lutjen


Oocyte donation, unlike its male counterpart of sperm donation which has been a routine clinical treatment for male infertility for many years, has only become feasible since the widespread introduction of in vitro fertilization (IVF). Prior to the advent of IVF there was neither a source of oocytes for donation nor the laboratory or clinical techniques available to ensure successful fertilization and transfer of the resulting embryo. There are now several reports in the literature of successful pregnancies following oocyte donation to patients either unwilling or unable to conceive from their own oocytes (Lutjen et al. 1984; Feichtinger and Kemeter 1985; Navot et al. 1986; Rosenwaks et al. 1986; Asch et al. 1987; Serhal and Craft 1987; Devroey et al. 1987). A number of variations in the clinical use of donated oocytes now exist. These include fertilization with husband or donor semen, transfer to recipients with or without endogenous ovarian function, and more recently, the use of gamete intra-fallopian transfer (GIFT) rather than IVF (Asch et al. 1987). In addition to providing an avenue for successful pregnancy in those patients with hypergonadotrophic hypogonadism or inheritable genetic disorders, oocyte donation also provides a unique opportunity for the study and understanding of the steroid replacement parameters necessary to induce uterine receptivity, the synchronization of embryo development with uterine receptivity prior to implantation, and the endocrinology of pregnancy in the absence of ovarian function.


Embryo Transfer Corpus Luteum Premature Ovarian Failure Oocyte Donation Luteinizing Hormone Surge 
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  1. Allan WM, Corner GN (1930) Physiology of corpus luteum. VII. Maintenance of pregnancy in rabbit after very early castration, by corpus luteum extracts. Proc Soc Exp Biol Med 27:403–405Google Scholar
  2. Asch R, Balmaceda J, Ord T et al. (1987) Oocyte donation and gamete intrafallopian transfer as treatment for premature ovarian failure. Lancet I:687–688CrossRefGoogle Scholar
  3. Bigazzi M, Nardig E, Petrucci F et al. (1983) Synthesis of relaxin by human decidua. In: Bigazzi M, Greenwood FC, Gasparri F (eds) Biology of Relaxin and its Role in the Human. Excerpta Medica, Amsterdam, pp 206–212Google Scholar
  4. Bustillo M, Buster J, Cowen S (1984) Delivery of a healthy infant following non-surgical ovum transfer. JAMA 251:889PubMedCrossRefGoogle Scholar
  5. Cate RL, Mattaliano RJ, Hessian C et al. (1986) Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animals. Cell 45:685–698PubMedCrossRefGoogle Scholar
  6. Csapo AI, Pulkkinen MO (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy. Luteo-placental shift in progesterone source. Obstet Gynecol Survey 33:69–81CrossRefGoogle Scholar
  7. Csapo AI, Pulkkinen MO, Wiest NG (1973) Effects of luteectomy and progesterone replacement therapy in early pregnancy patients. Am J Obstet Gynecol 115:759–765PubMedGoogle Scholar
  8. Derynck R, Jarrett JA, Chen EY et al. (1985) Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316:701–705PubMedCrossRefGoogle Scholar
  9. Devroey P, Smitz J, Wisanto A et al. (1987) Primary ovarian failure: embryo donation after substitution therapy. 5th world congress on IVF and ET. Norfolk, Virginia, 5–10 April (Abstract No OC-427)Google Scholar
  10. Fawcett DW, Wislocki GB, Waldo CM (1947) The development of mouse ova in the anterior chamber of the eye and in the abdominal cavity. Am J Anat 81:413–443PubMedCrossRefGoogle Scholar
  11. Feichtinger W, Kemeter P (1985) Pregnancy after total ovariectomy achieved by ovum donation. Lancet II:722–723CrossRefGoogle Scholar
  12. Hodgson YM, Averill S, Torney A, de Kretser DM (1987) A fetal source of inhibin demonstrated by in situ hybridisation. Society for the study of fertility, York (abstract 41)Google Scholar
  13. Kirby DRS (1963) The development of mouse blastocysts transplanted to the scrotal and cryptorchid testis. J Anat 97:119–130PubMedGoogle Scholar
  14. Leeton J, Harman J (1986). Attitudes towards egg donation of thirty-four infertile women who donated during their in vitro fertilization treatment. J In Vitro Fertil Embryo Transfer 6:374–378CrossRefGoogle Scholar
  15. Leeton J, Harman J (1987) The donation of oocytes to known recipients. Aust NZ J Obstet Gynaecol 27:248–250CrossRefGoogle Scholar
  16. Leeton J, Trounson A, Jessup D, Wood C (1982) The technique for human embryo transfer. Fertil Steril 38:156–161PubMedGoogle Scholar
  17. Leeton J, Chan C, Trounson A, Harman J (1986a) Pregnancy established in an infertile patient after transfer of an embryo fertilized in vitro where the oocyte was donated by the sister of the recipient. J In Vitro Fertil Embryo Transfer 6:379–382CrossRefGoogle Scholar
  18. Leeton J, Caro C, Howlett D, Harman J (1986b). The search for donor eggs: a problem of supply and demand. J Clin Reprod Fertil 4:337–340Google Scholar
  19. Lenz S (1984) Ultrasonic guided aspiration of human oocytes. Ultrasound Med Biol 10:625–628PubMedCrossRefGoogle Scholar
  20. Lenz S, Leeton J, Renou P (1987) Transvaginal recovery of oocytes for in vitro fertilization using vaginal ultrasound. J In Vitro Fertil Embryo Transfer 4:51–55CrossRefGoogle Scholar
  21. Lutjen P, Trounson A, Leeton J, Findlay J, Wood C, Renou P (1984) The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 307:174–175PubMedCrossRefGoogle Scholar
  22. Lutjen PJ, Findlay JK, Trounson AO, Leeton JF, Chan LK (1986) Effect on plasma gonadotrophins of cyclic steroid replacement in women with premature ovarian failure. J Clin Endocrinol Metab 62:419–423PubMedCrossRefGoogle Scholar
  23. Mahadevan M, Trounson A, Leeton J (1983). Successful use of human semen cryobankmg for in vitro fertilization. Fertil Steril 40:340–343PubMedGoogle Scholar
  24. McLachlan RI, Robertson DM, de Kretser DM, Burger HG (1987a) Inhibin — a non-steroidal regulator of pituitary follicle stimulating hormone. Clin Endocrinol Metab 1:89–112Google Scholar
  25. McLachlan RI, Healy DL, Lutjen PJ, Findlay JK, de Kretser DM, Burger HG (1987b) The maternal ovary is not the source of circulating inhibin levels during human pregnancy. Clin Endocrinol 27:663–668CrossRefGoogle Scholar
  26. McCullagh DR (1932) Dual endocrine control of the testes. Science 76:19–27PubMedCrossRefGoogle Scholar
  27. Muttram JC, Cramer W (1923) On the general effects of exposure to radium on metabolism and tumour growth in the rat and the special effects on testis and pituitary., QJ Exp Physiol 13:209–226Google Scholar
  28. Murphy CR, Rogers PAW, Leeton J, Hosie M, Beaton L, Macpherson A (1987) Surface ultrastructure of uterine epithelial cells in women with premature ovarian failure following steroid hormone replacement. Acta Anat 130:348–350PubMedCrossRefGoogle Scholar
  29. Navot D, Lanfer N, Kopolovic J et al. (1986) Artificially induced endometrial cycles and establishment of pregnancies in the absence of ovaries. N Engl J Med 314:806–811PubMedCrossRefGoogle Scholar
  30. Noyes RW, Dickman Z (1960) Relationship of ovular age to endometrial development. J Reprod Fertil 1:186–196CrossRefGoogle Scholar
  31. Noyes RW, Hertig AT, Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1:3–25Google Scholar
  32. O’Byrne EM, Flitcraft JF, Sawyer WR, Hochman J, Weiss G, Steinetz BG (1978) Relaxin bioactivity and immunoactivity in human corpora lutea. Endocrinology 102:1641–1644PubMedCrossRefGoogle Scholar
  33. Padgett RW, Johnston D St, Gelbart WM (1987) A transcript from a drosophilia pattern gene predicts a protein homologous to the transforming growth factor-β family. Nature 325:81–84PubMedCrossRefGoogle Scholar
  34. Psychoyos A, Casimiri V (1981) Uterine blastotoxic factors. In: Glasser SR, Bullock DW (eds) Cellular and molecular aspects of implantation. Plenum Press, New York, pp 327–334Google Scholar
  35. Rogers PAW, Milne B, Trounson AO (1986) A model to show uterine receptivity and embryo viability following ovarian stimulation for in vitro fertilization. J In Vitro Fertil Embryo Transfer 3:93–98CrossRefGoogle Scholar
  36. Rogers PAW, Macpherson A, Beaton L (1988) Embryo implantation in the anterior chamber of the eye: effects on uterine allografts and the microvasculature. Ann NY Acad Sci (in Press)Google Scholar
  37. Rosenwaks Z, Veeck LL, Hurg-Ching L (1986) Pregnancy following transfer of in vitro fertilized donated oocytes. Fertil Steril 45:417–420PubMedGoogle Scholar
  38. Serhal P, Craft I (1987) Simplified treatment for ovum donation. Lancet 1:687–688PubMedCrossRefGoogle Scholar
  39. Szalachter N, O’Bryne E, Goldsmith L et al. (1980) Myometrial inhibiting activity of relaxincontaining extracts of human corpora lutea of pregnancy. Am J Obstet Gynecol 136:584–589Google Scholar
  40. Templeton A, Van Look P, Lumsden M et al. (1984) The recovery of pre-ovulatory oocytes using a fixed schedule of ovulation induction and follicle aspiration. Br J Obstet Gynaecol 91:148–154PubMedCrossRefGoogle Scholar
  41. Trounson A, Leeton J, Besanko M, Wood C, Conti A (1983) Pregnancy established in an infertile patient after transfer of a donated embryo fertilized in vitro. Br Med J 286:835–838CrossRefGoogle Scholar
  42. Walters DE, Edwards RG, Meistrich ML (1985) A statistical evaluation of implantation after replacing one or more human embryos. J Reprod Fertil 74:557–563PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P. A. W. Rogers
  • J. Leeton
  • I. T. Cameron
  • C. Murphy
  • D. L. Healy
  • P. Lutjen

There are no affiliations available

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