Abstract
Human spontaneous abortions have been the subject of many cytogenetic investigations because they are a source of a large number and variety of abnormal chromosome complements (karyotypes). For the same reason, they can be very informative material for the epidemiologist, as Professor Alberman has already demonstrated.(1)
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References
Alberman ED. The epidemiology of repeated abortion. In: Early pregnancy lossmechanisms and treatment. Eds. RW Beard, F Sharp London: Royal College of Obstetricians and Gynaecologists, 1988. pp.9–17.
Penrose LS, Delhanty JDS. Triploid cell culture from a macerated fetus. Lancet 1961; 1: 1261–1262.
Carr DH. Chromosome anomalies as a cause of spontaneous abortion. Amer J Obstet Gynec 1967; 97: 283–293.
Stevenson AC, Dudgeon MY, McClure H. I. Observations on the results of pregnancies in women resident in Belfast II. Abortions, hydatidiform moles and ectopic pregnancies. Ann Hum Genet 1959; 23: 395–411.
Boué J, Boué A, Lazar P. The epidemiology of human spontaneous abortions with chromosomal anomalities. In: Aging Gametes. Ed. RJ Blandu. Basel: Karger, 1975; pp.330–348.
Alberman E, Creasy M, Elliott M, Spicer C. Maternal factors associated with fetal chromosomal anomalies in spontaneous abortions. Brit J Obstet Gynaecol 1976; 83: 621–627.
Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J, Matsuyama A, Wilson C, Yamana JA, Jacobs PA. A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet 1980; 44: 151–178.
Creasy MR, Crolla JA, Alberman ED. A cytogenetic study of human spontaneous abortions using banding techniques. Hum Genet 1976; 31: 177–196.
Warburton D, Stein Z, Kline J, Susser M. Chromosome abnormalities in spontaneous abortions: Data from the New York City study. In: Human Embryonic and Fetal Death. Eds. IH Porter, EB Hook. New York: Academic Press, 1980; 261–287.
Dhadial RK, Machin AM, Tait SM. Chromosomal anomalies in spontaneously aborted human fetuses. Lancet 1970; 2: 20–21.
Takahara H, Ohama K, Fujiwara A. Cytogenetic study in early spontaneous abortion. Hiroshima J Med Sci 1977; 26: 291–296.
Kajii T, Ferrier A, Niikawa N, Takahara H, Ohama K, Avirachan S. Anatomic and chromosomal anomalies in 639 spontaneous abortuses. Hum Genet 1980; 55: 87–98.
Thcrkelscn AJ, Grunnet N, Hjort T, Myre Jansen O, Jonasson J, Lauritsen JG, Lindstcn J, Bruun Petersen G. Studies on spontaneous abortion. In: Chromosomal Errors in Relation to Reproductive Failure. Eds. A Boué, C. Thibault. Paris: INSERM, 1973; pp.81–93.
Geisler M, Kleinebrecht J. Cytogenetic and histologic analyses of spontaneous abortions. Hum Genet 1978; 45: 239–251.
Arakaki DT, Waxman SH. Chromosomal abnormalities in early spontaneous abortions. J Med Genet 1970; 7: 118–124.
Stenchever MA, Hempel JM, McIntyre MN. Cytogenetics of spontaneously aborted human fetuses. Obstet Gynec 1967; 30: 683–691.
Leridon H, Boué J. La mortalité intra-utérine d’origine chromosomique. Population 1971; 26: 113–138.
Alberman ED, Creasy MR. Frequency of chromosomal abnormalities in miscarriages and perinatal deaths. J Med Genet 1977; 14: 313–315.
Watt JL, Templeton AA, Messinis I, Bell L, Cunningham P, Duncan RO. Trisomy 1 in an eight cell human pre-embryo. J Med Genet 1987; 24: 60–64.
Carr DH, Gedeon M. Population cytogenetics of human abortuses. In: Population Cytogenetics. Studies in Humans. Eds. EB Hook, IH Porter New York: Academic Press 1977; 1–9.
Ikeuchi T, Sasaki M, Fujimoto S. Chromosome studies on spontaneous and threatened abortions. Jap J Hum Genet 1975; 20: 245–246.
Meulenbroek GH, Geraedts JP. Parental origin of chromosome abnormalities in spontaneous abortions. Hum Genet 1982; 62: 129–133.
Warburton D, Yu CY, Kline J, Stein Z. Mosaic autosomal trisomy in cultures from spontaneous abortions. Amer J Hum Genet 1978; 30: 609–617.
Kajii T, Omaha K. Inverse maternal age effect in monosomy X. Hum Genet 1979; 51: 147–151.
Warburton D, Stein Z, Kline J, Susser M. Monosomy X: a chromosomal anomaly associated with young maternal age. Lancet 1980; 1: 167–169.
Creasy MR. Chromosome aberrations as a cause of prenatal death. In: Paediatric Research. A Genetic Approach Eds. M Adinolfi, P Benson, F Gianelli, M Seller London: Spastics International Medical Publications 1982; pp.122–135.
Polani PE. The incidence of chromosomal malformations. Proc Roy Soc Med 1970; 63: 50–52.
Creasy MR, Crolla JA. Prenatal mortality of trisomy 21 (Down’s syndrome). Lancet 1974; 1: 473–474.
Gropp A, Putz B, Zimmerman U. Autosomal monosomy and trisomy causing development failure. In: Developmental Biology and Pathology. Current Topics in Pathology 62. Eds. E Grundmann, WH Kirsten. Berlin: Springer 1976; pp.177–192.
Boué A, Boué J, Gropp A. Cytogenetics of pregnancy wastage. Adv Hum Genet 1985; 14: 1–57.
Polani PE, Adinolfi M. Chromosome 21 of man, 22 of the great apes and 16 of the mouse. Dev Med Child Neurol 1980; 22: 223–225.
Boué A, Boué J. Evaluation des erreurs chromosomique au moment du conception. Bioméd 1973; 18: 372–374.
Hassold TJ. A cytogenetic study of repeated spontaneous abortion. Am J Hum Genet 1980; 32: 723–730.
Alberman E, Elliott M, Creasy M, Dhadial R. Previous reproductive history in mothers presenting with spontaneous abortions. Brit J Obstet Gynaec 1975; 82: 366–373.
Jacobs PA, Hassold TJ. The origin of chromosome abnormalities in spontaneous abortion. In: Human Embryonic and Fetal Death. Eds. IH Porter, EB Hook. New York: Academic Press 1980; pp.289–298.
Mikkelsen M. Down syndrome. Current state of epidemiology. In: Human Genetics. Part B. Ed. B Bonne-Tamir. New York: Alan R Liss 1982; pp.297–307.
Ford CE. The time in development at which gross genome imbalance is expressed. In: The Early Development of Mammals. Eds. M Balls, AE Wild. London University Press 1975; pp.285–304.
Maudlin I, Fraser LR. Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos. J Reprod Fert 1978; 54: 423–426.
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Creasy, R. (1988). The cytogenetics of spontaneous abortion in humans. In: Sharp, F., Beard, R.W. (eds) Early Pregnancy Loss. Springer, London. https://doi.org/10.1007/978-1-4471-1658-5_39
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DOI: https://doi.org/10.1007/978-1-4471-1658-5_39
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