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The Decidua in Early Pregnancy

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Book cover Early Pregnancy Loss

Abstract

The decidua is the transformed stromal part of gestational endometrium. Endometrial stromal cells, which have been primed by oestrogen, enlarge and store glycogen under the influence of progesterone. Decidualisation occurs only in those species with haemochoriall placentation and hence is likely to playa key role,(1) but despite various investigational approaches, the function of decidua remains unclear. Recent studies have focused on the possible role of decidua in maternal immune acceptance of the feto-placental unit. Immunohistochemical studies have allowed in situ characterisation of decidual cell populations throughout pregnancy. However, functional studies continue to be limited by poor documentation of cells under investigation.

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References

  1. Robertson WB. The Endometrium. London: Butterworths Press, 1981; pp.7–44.

    Google Scholar 

  2. Bulmer JN, Johnson PM. Macrophage populations in the human placenta and amniochorion. Clin Exp Immunol 1984; 57: 393–403.

    PubMed  CAS  Google Scholar 

  3. Bulmer JN, Smith J, Morrison L, Wells, M. Maternal and fetal cellular relationships in the human placental basal plate. Placenta 1987; In press.

    Google Scholar 

  4. Bulmer JN, Morrison L, Smith JC. Expression of class II MHC gene products by macrophages in human uteroplacental tissue. Immunol 1987; In press.

    Google Scholar 

  5. Ritson A, Bulmer JN. Endometrial granulocytes in human decidua react with a natural killer cell marker, NKH1. Immunol 1987; In press.

    Google Scholar 

  6. Sutton L, Mason DY, Redman CWG. HLA-DR positive cells in the human placenta. Immunology 1983; 49: 103–112.

    PubMed  CAS  Google Scholar 

  7. Kabawat SE, Mostoufi-Zadeh M, Driscoll SG, Bhan AK. Implantation site in normal pregnancy. A study with monoclonal antibodies. Am J Pathol 1985; 118: 76–84.

    PubMed  CAS  Google Scholar 

  8. Nehemiah JL, Schnitzer JA, Schulman H, Novikoff AB. Human chorionic trophoblasts, decidual cells and macrophages: a histochemical and electron microscopic study. Am J Obstet Gynecol 1981; 140: 261–268.

    PubMed  CAS  Google Scholar 

  9. Earl U, Lunny DP, Bulmer JN. Leucocyte populations in ectopic tubal pregnancy. J Clin Pathol 1987; 40: 901–905.

    Article  PubMed  CAS  Google Scholar 

  10. Bulmer JN, Sunderland CA. Immunohistological characterization of lymphoid populations in the early human placental bed. Immunology 1984; 52: 349–357.

    PubMed  CAS  Google Scholar 

  11. Bulmer JN, Johnson PM. The T-lymphocyte population in first-trimester human decidua does not express the interleukin-2 receptor. Immunology 1986; 58: 685–687.

    PubMed  CAS  Google Scholar 

  12. Bulmer JN, Hollings D, Ritson A. Immunocytochemical evidence that endometrial stromal granulocytes are granulated lymphocytes. J Path 1987; In press.

    Google Scholar 

  13. Bulmer JN, Hagin SV, Browne CM, Billington WD. Localization of immunoglobulincontaining cells in human endometrium in the first trimester of pregnancy and throughout the menstrual cycle. Eur J Obstet Gynecol Reprod Biol 1986; 23: 31–44.

    Article  PubMed  CAS  Google Scholar 

  14. Dallenbach-Hellweg G. Histopathology of the endometrium. Berlin: Springer-Verlag, 1981; pp.22–88.

    Google Scholar 

  15. Bulmer JN, Johnson PM, Bulmer D. Leucocyte populations in human decidua and endometrium. In: Immunoregulation and fetal survival. Eds. TG Gill III, TG Wegman. New York: Oxford University Press, 1987; pp.111–134.

    Google Scholar 

  16. Kamut BR, Isaacson PG. The immunocytochemical distribution of leucocytic subpopulations in human endometrium. Am J Pathol 1987; 127: 66–73.

    Google Scholar 

  17. Morris H, Edwards J, Tiltman A, Emms M. Endometrial lymphoid tissue: an immunohistological study. J Clin Pathol 1985; 38: 644–652.

    Article  PubMed  CAS  Google Scholar 

  18. Daly DC, Maslar IA, Riddick DH. Prolactin production during in vitro decidualization of proliferative endometrium. Am J Obstet Gynecol 1983; 145: 672–678.

    PubMed  CAS  Google Scholar 

  19. Oksenberg JR, Mor Yosef S, Persitz E, Schenker Y, Mozes E, Brautbar C. Antigenpresenting cells in human decidual tissue. Am J Reprod Immunol Microbiol 1986; 11: 82–88.

    PubMed  CAS  Google Scholar 

  20. Lala PK, Parchar RS, Kearns M, Johnson S, Scodras JM. Immunologic aspects of the decidual response. In: Reproductive Immunology 1986. Eds. DA Clark, BA Croy. Amsterdam: Elsevier Science Publishers, 1986; pp.190–198.

    Google Scholar 

  21. Tawfik OW, Hunt JS, Wood GW. Implication of prostaglandin E2 in soluble factormediated immune suppression by murine decidual cells. Am J Reprod Immunol Microbiol 1986; 12: 111–117.

    PubMed  CAS  Google Scholar 

  22. Clark DA, Slapsys R, Croy BA, Krcek J, Rossant J. Local active suppression by suppressor cells in the decidua: a review. Am J Reprod Immunol 1984; 5: 78–83.

    PubMed  CAS  Google Scholar 

  23. Daya S, Clark DA, Devlin C, Jarrell J, Chaput A. Suppressor cells in human decidua. Am J Obstet Gynecol 1985; 151: 267–270.

    PubMed  CAS  Google Scholar 

  24. Ritson A, Bulmer JN. Extraction of leucocytes from human decidua: a comparison of dispersal techniques. J Immunol Methods 1987; In press.

    Google Scholar 

  25. Gambel P, Rossant J, Hunziker RD, Wegmann TG. Origin of decidual cells in murine pregnancy and pseudopregnancy. Transplantation 1985; 39: 443–445.

    Article  PubMed  CAS  Google Scholar 

  26. Clark DA, Brierly J, Slapsys R, Daya S, Damji N, Chaput A, Rosenthal K. Trophoblast dependent and trophoblast independent suppressor cells of maternal origin in murine and human decidua. In: Reproductive Immunology 1986. Eds. DA Clark, BA Croy. Amsterdam: Elsevier Science Publishers, 1986; pp.219–226.

    Google Scholar 

  27. Ritson A, Bulmer JN. The isolation and characterisation of granulated lymphocytes from first trimester human decidua. Submitted.

    Google Scholar 

  28. Reynolds CW, Ortaldo JR. Natural killer activity: the definition of a function rather than a cell type. Immunol Today 1987; 8: 172–174.

    Article  Google Scholar 

  29. Lanier LL, Le AM, Civin CI, Loken MR, Phillips JH. The relationship of CD16 (Leu 11) and Leu 19 (NKH -1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 1986; 136: 4480–4486.

    PubMed  CAS  Google Scholar 

  30. Gregory CD, Lee H, Scott IV, Golding PR. Phenotypic heterogeneity and recycling capacity of natural killer cells in normal human pregnancy. J Reprod Immunol 1987; 11: 135–145.

    Article  PubMed  CAS  Google Scholar 

  31. Croy BA, Gambel P, Rossant J, Wegmann TG. Characterization of murine decidual natural killer 2(NK) cells and their relevance to the success of pregnancy. Cell Immunol 1985; 93: 315–326.

    Article  PubMed  CAS  Google Scholar 

  32. Golander G, Zakuth V, Shechter Y, Spirer Z. Suppression of lymphocyte reactivity in vitro by a soluble factor secreted by explants of human decidua. Eur J Immunol 1981; 11: 849–851.

    Article  PubMed  CAS  Google Scholar 

  33. Clark DA, Chaput A. Local intrauterine suppressor cells and suppressor factors in survival of the fetal allograft. In: Reproductive Immunology: Materno-Fetal Relationship. Ed. G Chaouat. Paris: INSERM, 1987; pp.77–88.

    Google Scholar 

  34. Johnson PM, Risk JM, Bulmer JN, Niewola Z, Kimber I. Antigen expression at maternofetal interfaces. In: Immunoregulation and Fetal Survival. Eds. TJGill III, TG Wegmann. New York: Oxford University Press, 1987; pp.181–196.

    Google Scholar 

  35. Mowbray IF. Underwood JL. Immunisation with paternal cells for recurrent spontaneous abortion. In: Reproductive Immunology: Materno-Fetal Relationship. Ed: G Chaouat. Paris: INSERM. 1987; pp.179–186.

    Google Scholar 

  36. Beer AE, Shekar SS, Quebbeman IF; Zhu X. Paternal and non-paternal leucocyte immunisation in women with recurrent spontaneous abortions: immune responses and subsequent pregnancy outcome. In: Reproductive Immunology: Materno-Fetal Relationship. Ed. G Chaouat. Paris: INSERM, 1987; pp.161–178.

    Google Scholar 

  37. Soffer Y, Caspi E, Weinstein Y. Endometrial cell mediated immunity and contraception: new perspectives. In: Immunological factors in human contraception. Field Educational Italia Acta Medica, 1983; pp.161–167.

    Google Scholar 

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© 1988 The Royal College of Obstetricians and Gynaecologists

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Bulmer, J.N., Ritson, A. (1988). The Decidua in Early Pregnancy. In: Sharp, F., Beard, R.W. (eds) Early Pregnancy Loss. Springer, London. https://doi.org/10.1007/978-1-4471-1658-5_20

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  • DOI: https://doi.org/10.1007/978-1-4471-1658-5_20

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1660-8

  • Online ISBN: 978-1-4471-1658-5

  • eBook Packages: Springer Book Archive

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