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Combination Therapy in Urological Malignancy pp 95–118Cite as

Management of Invasive Bladder Neoplasms

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Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

Infiltrating bladder tumours encompass a broad clinical spectrum exhibiting varied biological potential. While the term can be applied biologically to any tumour that extends beyond the in situ category, urologically it implies muscle infiltration and uniform recommendations concerning management are lacking. Once infiltration is documented, the ability to control the disease by transurethral resection diminishes, thus, radical surgery, with or without radiation therapy is commonly recommended. Clinical trials reporting the results of these approaches vary with respect to case selection criteria for the given treatment, the extent of pretreatment staging and restaging, and time to and specific site(s) of relapse. More important is that few studies are randomised, the number of patients actually receiving the planned therapy is small and follow-up time too short to assess the impact of a particular strategy on either local control or survival. Frequently neglected is the fact that these diseases occur in an older population with a variety of intercurrent medical problems which preclude an aggressive combined modality approach. Death rates from non-cancer-related causes can be significant and are rarely factored in to the reported results.

Dr. Sternberg and Dr. Scher are recipients of The American Cancer Society Clinical Oncology Career Development Awards.

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Authors
  1. Cora N. Sternberg
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  2. H. I. Scher
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Editors and Affiliations

  1. St James’s University Hospital, Beckett Street, LS9 7TF, Leeds, UK

    Philip H. Smith MB, FRCS (Consultant Urologist) (Consultant Urologist)

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Sternberg, C.N., Scher, H.I. (1989). Management of Invasive Bladder Neoplasms. In: Smith, P.H. (eds) Combination Therapy in Urological Malignancy. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1655-4_6

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  • DOI: https://doi.org/10.1007/978-1-4471-1655-4_6

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