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Ankylosing Spondylitis and Reiter’s Disease

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Abstract

Although very different in their clinical presentation and course, ankylosing spondylitis and Reiter’s disease have a number of significant features in common. The most important of these are sacro-iliitis, a high incidence of the histocompatibility antigen HLA-B27, and their effects on the heart.

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References

  • Ansell BM, Bywaters EGL, Doniach I (1958) The aortic lesion of ankylosing spondylitis. Br Heart J 20: 507–515

    Article  PubMed  CAS  Google Scholar 

  • Archer JR, Winrow VR (1987) HLA-B27 and the course of arthritis: does molecular biology help? Ann Rheum Dis 46: 713–715

    Article  PubMed  CAS  Google Scholar 

  • Ball J (1980) Pathology and pathogenesis. In: Moll JMH (ed) Ankylosing spondylitis. Churchill Livingstone, Edinburgh, pp 96–112

    Google Scholar 

  • Bauer W, Clarke WS, Kulka JP (1951) Aortitis and aortic endocarditis; an unrecognised manifestation of rheumatoid arthritis. Ann Rheum Dis 10: 470–471

    PubMed  CAS  Google Scholar 

  • Bennett PH, Wood PHN (eds) (1968) Population studies of the rheumatic diseases. Excerpta Medica Foundation, Amsterdam, pp 456–457

    Google Scholar 

  • Bergfeldt L, Edhag O, Vallin H (1982a) Cardiac conduction disturbances, an underestimated manifestation in ankylosing spondylitis. Acta Med Scand 212: 217–223

    Article  PubMed  CAS  Google Scholar 

  • Bergfeldt L, Edhag O, Vedin L, Vallin H (1982b) Ankylosing spondylitis: an important cause of severe disturbances of the cardiac conducting system. Prevalence among 223 pacemaker treated men. Am J Med 73: 187–191

    Article  PubMed  CAS  Google Scholar 

  • Bergfeldt L, Edhag O, Rajs J (1984a) HLA-B27 associated heart disease. Am J Med 77: 961–967

    Article  PubMed  CAS  Google Scholar 

  • Bergfeldt L, Vallin H, Edhag O (1984b) Complete heart block in HLA-B27 associated disease. Electrophysiological and clinical characteristics. Br Heart J 51: 184–188

    Google Scholar 

  • Bernstein L, Broch OJ (1949) Cardiac complications in spondylarthritis ankylopoietica. Acta Med Scand 135: 185–194

    Google Scholar 

  • Bistry O, De Prost Y, Scheuble C, Frank R, Godeau P (1979) Syndrome de Fiessinger-Leroy - Reiter avec cardiomyopathie non-obstructive. Arch Mai Coeur 72: 799–805

    Google Scholar 

  • Brewerton DA (1983) A search for infective agents in spondylitis and uveitis. Br J Rheumatol 22 (suppl 2): 91–92

    Google Scholar 

  • Brewerton DA, Caffrey M, Hart FD, James DCO, Nicholls A, Sturrock RD (1973) Ankylosing spondylitis and HLA–27. Lancet I: 94–907

    Google Scholar 

  • Brewerton DA, Gibson DG, Goodard DH et al. (1987) The myocardium in ankylosing spondylitis. A clinical, echocardiographic and histopathological study. Lancet I: 995–998

    Google Scholar 

  • Bulkley BH, Roberts WC (1973) Ankylosing spondylitis and aortic regurgitation. Circulation 48: 1014–1027

    PubMed  CAS  Google Scholar 

  • Calin A (1983) Spondylarthropathy in Caucasians and non-Caucasians. J Rheumatol 10 (suppl 10); 16–18

    CAS  Google Scholar 

  • Calin A (1984) Seronegative arthritis. Medicine International 2 (22): 912–917

    Google Scholar 

  • Calin A, Fries JF (1975) Striking prevalence of ankylosing spondylitis in “healthy” W27 positive males and females: a controlled study. N Engl J Med 293: 835–839

    Article  PubMed  CAS  Google Scholar 

  • Calin A, Fries JF, Stinson JE, Payne R (1976) Normal frequency of HLA-B27 in aortic insufficiency. N Engl J Med 294: 397

    PubMed  CAS  Google Scholar 

  • Calin A, Marder A, Becks E, Burns T (1983) Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls. Arthritis Rheum 26: 470–474

    Article  Google Scholar 

  • Clark WS, Kulka JP, Bauer W (1957) Rheumatoid aortitis with aortic regurgitation, an unusual manifestation of rheumatoid arthritis (including spondylitis). Am J Med 22: 580–592

    Article  PubMed  CAS  Google Scholar 

  • Cliff JM (1971) Spinal bony bridging and carditis in Reiter’s disease. Ann Rheum Dis 30: 171–179

    Article  PubMed  CAS  Google Scholar 

  • Cohen LM, Mittal KK, Schmid FR, Rogers LF, Cohen KL (1976) Increased risk of spondylitis stigmata in apparently healthy HLA-W27 men. Ann Intern Med 84: 1–7

    PubMed  CAS  Google Scholar 

  • Cosh JA, Lever JV (1984) The aortic valve. In Ansell BM, Simkin PA (eds) The heart and rheumatic disease. Butterworths, London, pp. 83–119

    Google Scholar 

  • Crow RS (1960) Aortic incompetence in ankylosing spondylitis. Br Med J 2: 271–273

    Article  PubMed  CAS  Google Scholar 

  • Csonka GW (1979) Clinical aspects of Reiter’s syndrome. Ann Rheum Dis; 38 (suppl) 4–7 and 24–28

    Google Scholar 

  • Csonka GW, Oates JK (1957) Pericarditis and electrocardiographic changes in Reiter’s syndrome. Br Med J 1: 866–869

    Article  PubMed  CAS  Google Scholar 

  • Csonka GW, Litchfield JW, Oates JK, Willcox, RR (1961) Cardiac lesions in Reiter’s disease. Br Med J I: 243–247

    Google Scholar 

  • Davidson P, Baggenstoss AH, Slocumb CH, Daugherty GW (1963) Cardiac and aortic lesions in rheumatoid spondylitis. Mayo Clin Proc 36: 427–435

    Google Scholar 

  • Davies MJ (1984) Disorders of the conduction system. In: Ansell BM, Simkin PA (eds) The heart and rheumatic disease. Butterworths, London, pp 69–73

    Google Scholar 

  • Demoulin JC, Lespagnard J, Bertholet M, Soumagne D (1983) Acute fulminant aortic regurgitation in ankylosing spondylitis. Am Heart J 105: 859–861

    Article  PubMed  CAS  Google Scholar 

  • Dubost JJ, Sauvezie B, Galtier B et al. (1985) Behcet’s syndrome and ankylosing spondylitis. Rev Rhum Mai Osteoartic 52: 457–461

    CAS  Google Scholar 

  • Ebringer A (1983) The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis. Br J Rheumatol 22 (suppl 2): 53–66

    PubMed  CAS  Google Scholar 

  • Editorial, Lancet (1985) Is Reiter’s syndrome caused by chlamydia? Lancet I: 317

    Google Scholar 

  • Eghtedari AA, Davis P, Bacon PA (1976) Immunological reactivity in ankylosing spondylitis. Ann Rheum Dis 35: 155–157

    Article  PubMed  CAS  Google Scholar 

  • Eversmeyer WH, Rosenstock D, Biundo JJ (1978) Aortic insufficiency with mild ankylosing spondylitis in black men. JAMA 240: 2652–2653

    Article  PubMed  CAS  Google Scholar 

  • Feigenbaum H (1980) Echocardiography. In: Braunwald E (ed) Heart disease. Saunders, London pp 96–146

    Google Scholar 

  • Fox R, Calin A, Gerber RC, Gibson D (1979) The chronicity of symptoms and disability in Reiter’s syndrome. An analysis of 131 consecutive patients. Ann Intern Med 91: 190–193

    PubMed  CAS  Google Scholar 

  • Gladman DD, Anhorn KAB, Schachter RK, Mervart AH (1986) HLA antigens in psoriatic arthritis. J Rheumatol 13: 586–592

    PubMed  CAS  Google Scholar 

  • Good AE (1974) Reiter’s disease; a review with special attention to cardiovascular and neurogenic sequelae. Semin Arthritis Rheum 3: 253–286

    Article  PubMed  CAS  Google Scholar 

  • Gould BA, Turner J, Keeling DH, Hickling P, Marshall AJ (1988) Myocardial dysfunction in ankylosing spondylitics. Br Heart J 59: 129

    Article  Google Scholar 

  • Graham DC, Smythe HA (1958) The carditis and aortitis of ankylosing spondylitis. Bull Rheum Dis 9: 171–175

    PubMed  CAS  Google Scholar 

  • Guiney TE, Davies MJ, Parker DJ, Leech GJ, Leatham A (1987) The aetiology and course of isolated severe aortic regurgitation: a clinical, pathological and echocardiographic study. Br Heart J 58: 358–368

    Article  PubMed  CAS  Google Scholar 

  • Henssge R, Boehme A, Muller A (1970) Herzbeteiligung bei der Spondylitis ankylopoietica. Dtsch Gesundheitwes 25: 391–393

    CAS  Google Scholar 

  • Hollingworth P, Hall PJ, Knight SC, Newman R (1979) Lone aortic regurgitation, sacro-iliitis and HLA-B27: case history and frequency of association. Br Heart J 42: 229–230

    Article  PubMed  CAS  Google Scholar 

  • Hubscher O, Graci y Susini J (1984) Aortic insufficiency in Reiter’s disease of juvenile onset. J Rheumatol 11: 94–95

    Google Scholar 

  • Hudson REB (1967) Surgical pathology of the conducting system of the heart. Br Heart J 29: 646–670

    Article  PubMed  CAS  Google Scholar 

  • Hull RG, Asherson RA, Rennie JAN (1984) Ankylosing spondylitis and an aortic arch syndrome. Br Heart J 51: 663–665

    Article  PubMed  CAS  Google Scholar 

  • Kean WF, Anastassiades TP, Ford PM (1980) Aortic incompetence in HLA-B27 positive juvenile arthritis. Ann Rheum Dis 39: 294–295

    Article  PubMed  CAS  Google Scholar 

  • Keat A, Thomas B, Dixey J, Osborn M, Sonnex C, Taylor-Robinson D (1987) Chlamydia trachomatis and reactive arthritis: the missing link. Lancet I: 72–74

    Google Scholar 

  • Kinsella TD, Johnson LG, Sutherland RI (1974) Cardiovascular manifestations of ankylosing spondylitis. Canad Med Assoc J 111: 1309–1311

    PubMed  CAS  Google Scholar 

  • LaBresh KA, Lally EV, Sharma SC, Ho G (1985) Two dimensional echocardiographic detection of preclinical aortic root abnormalities in rheumatoid variant diseases. Am J Med 78: 908–912

    Article  PubMed  CAS  Google Scholar 

  • Laitinen O, Leirosalo M, Skylv G (1977) Relation between HLA-B27 and clinical features in patients with yersinia arthritis. Arthritis Rheum 20: 1121–1124

    Article  PubMed  CAS  Google Scholar 

  • Lawrence JS (1963) The prevalence of arthritis. Br J Clin Pract 17: 699–705

    PubMed  CAS  Google Scholar 

  • Leirosalo M, Skylv G, Kousa M et al. (1982) Follow up study on patients with Reiter’s disease and reactive arthritis with special reference to HLA-B27. Arthritis Rheum 25: 249–259

    Article  Google Scholar 

  • Malette WG, Eiseman B, Danielson GK, Mazzoleni A, Rams JJ (1969) Rheumatoid spondylitis and aortic insufficiency. J Thorac Cardiovasc Surg 57: 471–474

    PubMed  CAS  Google Scholar 

  • Mallory TB (1936) Case records of the Massachusetts General Hospital. N Engl J Med 214: 690–698

    Article  Google Scholar 

  • Masi AT (1979) Epidemiology of B27 associated diseases. Ann Rheum Dis 38 (suppl): 131–134

    Article  PubMed  Google Scholar 

  • Mazieres B, Constans R, Donzeau JP, Sacau P, Dardenne P, Arlet J (1979) Etude electrophysiologique de deux cas de bloc auriculo-ventriculaire secondaire a une spondylarthrite ankylo-sante. Rev Rhum Mai Osteoartic 46: 137–140

    CAS  Google Scholar 

  • McEwen C, Ditata D, Lingg C, Porini A, Good A, Rankin T (1971) Ankylosing spondylitis and spondylitis accompanying ulcerative colitis, regional enteritis, psoriasis and Reiter’s disease. Arthritis Rheum 14: 291–318

    Article  PubMed  CAS  Google Scholar 

  • McGuigan LE, Geczy AF, Edmonds JP (1985) The immunopathology of ankylosing spondylitis–a review. Semin Arthritis Rheum 15: 81–105

    Article  PubMed  CAS  Google Scholar 

  • Miller LD, Brown EC, Arnett FC (1979) Amyloidosis in Reiter’s syndrome. J Rheumatol 6: 225–231

    PubMed  CAS  Google Scholar 

  • Moll JMH (1983) Seronegative arthropathies (Editorial). J R Soc Med 76: 445–448

    PubMed  CAS  Google Scholar 

  • Moll JMH, Haslock I, Macrae IF, Wright V (1974) Associations between ankylosing spondylitis, psoriatic arthritis, Reiter’s disease, the intestinal arthropathies and Behcet’s syndrome. Medicine (Baltimore) 53: 343–364

    Google Scholar 

  • Muna WF, Roller DH, Craft J et al. (1980) Psoriatic arthritis and aortic regurgitation. JAMA 244: 363–365

    Article  PubMed  CAS  Google Scholar 

  • Nicholls A (1979) HLA antigens and rheumatic disease. Medicine, 3rd series: 690–692

    Google Scholar 

  • Nitter-Hauge S, Otterstad JE (1981) Characteristics of atrioventricular conduction disturbances in ankylosing spondylitis. Acta Med Scand 210: 197–200

    Article  PubMed  CAS  Google Scholar 

  • Noer HR (1966) An “experimental” epidemic of Reiter’s syndrome. JAMA 197: 117–122

    Google Scholar 

  • Paronen I (1948) Reiter’s disease; a study of 344 cases observed in Finland. Acta Med Scand; 131 (suppl 212): 1–114

    Google Scholar 

  • Paulus HE, Pearson CM, Pitts W (1972) Aortic insufficiency in 5 patients with Reiter’s syndrome. Am J Med 53: 464–472

    Article  PubMed  CAS  Google Scholar 

  • Oaiyumi S, Hassan ZU, Toone E (1985) Seronegative spondylarthropathies in lone aortic insuf-ficiency. Arch Intern Med 145: 822–824

    Article  Google Scholar 

  • Radford EP, Doll R, Smith PG (1977) Mortality among patients with ankylosing spondylitis not given X-ray therapy. N Engl J Med 297: 572–576

    Article  PubMed  CAS  Google Scholar 

  • Ribeiro P, Morley KD, Shapiro LM, Garnett RAF, Hughes GRV (1984) Left ventricular function in patients with ankylosing spondylitis and Reiter’s disease. Eur Heart J 5: 419–422

    PubMed  CAS  Google Scholar 

  • Roberts WC, Hollingworth JF, Bulkley BH et al. (1974) Combined mitral and aortic regurgitation in ankylosing spondylitis. Am J Med 56: 237–243

    Article  PubMed  CAS  Google Scholar 

  • Rossen RM, Goodman DJ, Harrison DC (1975) Atrio-ventricular conduction disturbances in Reiter’s syndrome. Am J Med 58: 280–284

    Article  PubMed  CAS  Google Scholar 

  • Ruppert G, Lindsay J, Barth WF (1982) Cardiac conduction abnormalities in Reiter’s syndrome. Am J Med 73: 335–340

    Article  PubMed  CAS  Google Scholar 

  • Sairanen E, Tiilikainen A (1975) HL-A27 in Reiter’s disease following shigellosis. Scand J Rheumatol 4 (suppl 8): abstract 30 /11

    Google Scholar 

  • Sairanen E, Paronen I, Mahonen H (1969) Reiter’s syndrome: a follow up study. Acta Med Scand 185: 57–63

    Article  PubMed  CAS  Google Scholar 

  • Schilder DP, Harvey WP, Hufnagel CA (1956) Rheumatoid spondylitis and aortic insufficiency. N Engl J Med 255: 11–17

    Article  PubMed  CAS  Google Scholar 

  • Siguier F, Godeau P, Herreman G et al. (1970) Insuffisance aortique, spondylarthrite ankylosante et syndrome de Fiessinger-Leroy-Reiter. Coeur Med Interne 9: 457–465

    PubMed  CAS  Google Scholar 

  • Sobin LH, Hagstrom JWC (1962) Lesions of cardiac conduction tissue in rheumatoid aortitis. JAMA 180: 1–5

    PubMed  CAS  Google Scholar 

  • Spangler RD, McAllister BD, McGoon DC (1970) Aortic valve replacement in patients with severe aortic valve incompetence associated with rheumatoid spondylitis. Am J Cardiol 26: 130–134

    Article  PubMed  CAS  Google Scholar 

  • Stewart SR, Robbins DL, Castles JJ (1978) Acute fulminant aortic and mitral insufficiency in ankylosing spondylitis. N Engl J Med 299: 1448–1449

    Article  PubMed  CAS  Google Scholar 

  • Takkunen J, Vuopala U, Isomaki H (1970) Cardiomyopathy in ankylosing spondylitis. I. Medical history and results of clinical examination in a series of 55 patients. Ann Clin Res 2: 106–112

    PubMed  CAS  Google Scholar 

  • Toone EC, Pierce EL, Hennigar GR (1959) Aortitis and aortic regurgitation associated with rheumatoid spondylitis. Am J Med 26: 255–263

    Article  PubMed  Google Scholar 

  • Tucker CR, Fowles RE, Calin A, Popp RL (1982) Aortitis in ankylosing spondylitis: early detection of aortic root abnormalities with two dimensional echocardiography. Am J Cardiol 49: 680–686

    Article  PubMed  CAS  Google Scholar 

  • Van der Linden S, Valkenburg H, Cats A (1983) The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study. Br J Rheumatol 22 (suppl 2): 18–19

    PubMed  Google Scholar 

  • Weed CL, Kulander BG, Mazzarella JA, Decker JL (1966) Heart block in ankylosing spondylitis. Arch Intern Med 117: 800–817

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson M, Bywaters EGL (1958) Clinical features and course of ankylosing spondylitis. Ann Rheum Dis 17: 209–228

    Article  PubMed  CAS  Google Scholar 

  • Willkens RF, Arnett FC, Bitter T et al. (1982) Reiter’s syndrome. Evaluation of preliminary criteria for definite disease. Bull Rheum Dis 32: 31–34

    Google Scholar 

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Authors and Affiliations

  1. Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, BA1 1RL, Bath, UK

    John A. Cosh MA MD (Cantab), FRCP (Honorary Consultant Physician) & John V. Lever BSc MBChB, FRCPath (Consultant Pathologist)

  2. Royal United Hospital, Combe Park, BA1 3NG, Bath, UK

    John A. Cosh MA MD (Cantab), FRCP (Honorary Consultant Physician) & John V. Lever BSc MBChB, FRCPath (Consultant Pathologist)

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  1. John A. Cosh MA MD (Cantab), FRCP
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  2. John V. Lever BSc MBChB, FRCPath
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© 1988 Springer-Verlag Berlin Heidelberg

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Cosh, J.A., Lever, J.V. (1988). Ankylosing Spondylitis and Reiter’s Disease. In: Rheumatic Diseases and the Heart. Springer, London. https://doi.org/10.1007/978-1-4471-1643-1_8

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  • DOI: https://doi.org/10.1007/978-1-4471-1643-1_8

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  • Print ISBN: 978-1-4471-1645-5

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