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Renal Failure and Transplantation in Primary Hyperoxaluria

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Oxalate Metabolism in Relation to Urinary Stone

Part of the book series: The Bloomsbury Series in Clinical Science ((BLOOMSBURY))

Abstract

Primary hyperoxaluria is a rare inherited metabolic disease in which striking oxalate overproduction is associated with recurrent calcium oxalate urolithiasis leading to end-stage renal failure before the end of the second or third decade. Because conventional methods of renal substitution such as regular dialysis or renal transplantation do not alter the underlying metabolic defect the longterm results of such treatments are far worse in patients with primary hyperoxaluria than in patients whose renal failure is due to other more common causes such as chronic glomerulonephritis or pyelonephritis. This chapter reviews recent developments in the management of patients with primary hyperoxaluria as they approach terminal renal failure, together with the timing and management of renal transplantation and the option of combined synchronous hepatic and renal transplantation.

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References

  • Adams MD, Carrera GF, Johnson RP, Latorraca R, Lemann J (1982) Calcium oxalate crystal induced bone disease. Am J Kid Dis 5: 294–299

    Google Scholar 

  • Ahmed S, Hatch M (1985) Hyperoxalemia in renal failure and the role of hemoperfusion and hemodialysis in primary oxalosis. Nephron 41: 235–240

    Article  Google Scholar 

  • Arbus GS, Sniderman S (1974) Oxalosis with peripheral gangrene. Arch Pathol Lab Med 97: 107–110

    CAS  Google Scholar 

  • Boer P, van Leersam L, Hene RJ, Mees EJD (1984) Plasma oxalate concentration in chronic renal disease. Am J Kid Dis 4: 118–122

    PubMed  CAS  Google Scholar 

  • Breed A, Chesney R, Friedman A et al. (1981) Oxalosis-induced bone disease: A complication of prolonged hemodialysis and transplantation in primary oxalosis. J Bone Joint Surg [Am] 63: 310–316

    CAS  Google Scholar 

  • Cattell WR, Spencer AG, Taylor GW, Watts RWE (1962) The mechanism for renal excretion of oxalate in the dog. Clin Sci 22: 43–51

    PubMed  CAS  Google Scholar 

  • Chesney RW, Friedman AL, Breed AL, Adams ND, Lemann J (1984) Renal transplantation in primary oxaluria. J Pediatr 104: 322–323

    PubMed  CAS  Google Scholar 

  • Constable AR, Joekes AM, Kasidas GP, O’Regan P, Rose GA (1979) Plasma level and renal clearance of oxalate in normal subjects and in patients with primary hyperoxaluria or chronic renal failure or both. Clin Sci 56: 299–304

    PubMed  CAS  Google Scholar 

  • Danpure CJ, Jennings PR (1986) Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I. FEBS Lett 201: 20–24

    Article  PubMed  CAS  Google Scholar 

  • Danpure CJ, Jennings PR, Watts RWE (1987) Enzymological diagnosis of primary hyperoxaluria type I by measurement of hepatic alanine-glyoxylate aminotransferase activity. Lancet I: 289–291

    Article  Google Scholar 

  • David DS, Cheigh JS, Stenbzel KH, Rubin AC (1983) Successful renal transplantation in a patient with primary hyperoxaluria. Transplant Proc 15: 2168–2171

    PubMed  CAS  Google Scholar 

  • Deodhar SD, Tung KSK, Zulke V, Nakamoto S (1969) Renal homotransplantation in a patient with primary familial oxalosis. Arch Pathol Lab Med 87: 118–124

    CAS  Google Scholar 

  • Fayemi A, Ali M, Bruan E (1979) Oxalosis in hemodialysis patients. Arch Pathol Lab Med 103: 58–62

    PubMed  CAS  Google Scholar 

  • Gherardi G, Poggi A, Sisca S et al. (1980) Bone oxalosis and renal osteodystrophy. Ann Intern Med 90: 777–779

    Google Scholar 

  • Gibbs DA, Watts RWE (1970) The action of pyridoxine in primary hyperoxaluria. Clin Sci 38: 277–286

    PubMed  CAS  Google Scholar 

  • Kasidas GP, Rose GA (1986) Measurement of plasma oxalate in healthy subjects and in patients with chronic renal failure using immobilised oxalate oxidase. Clin Chim Acta 154: 49–58

    Article  PubMed  CAS  Google Scholar 

  • Klauwers J, Wolff PL, Cohn R (1969) Failure of renal transplantation in primary oxalosis. JAMA 209: 551–554

    Article  PubMed  CAS  Google Scholar 

  • Morgan SH, Purkiss P, Watts RWE, Mansell MA (1987) Oxalate dynamics in chronic renal failure. Comparison with normal subjects and patients with primary hyperoxaluria. Nephron 46: 253–257

    Article  PubMed  CAS  Google Scholar 

  • Ramsay AG, Reed RG (1984) Oxalate removal by hemodialysis in end-stage renal disease. Am J Kid Dis 4: 123–127

    PubMed  CAS  Google Scholar 

  • Scheinman J, Najarian JS, Mauer SM (1984) Successful strategies for renal transplantation in primary oxalosis. Kidney Int 25: 804–811

    Article  PubMed  CAS  Google Scholar 

  • Stansfeld A, Scowen EF, Watts RWE (1959) Oxalosis and primary hyperoxaluria. J Pathol Bacteriol 77: 195–205

    Article  PubMed  Google Scholar 

  • Vanrentergham Y, Vandamme B, Lernt T, Michielsen P (1984) Severe vascular complications in oxalosis after successful cadaveric kidney transplantation. Transplantation 38: 93–95

    Article  Google Scholar 

  • Watts RWE, Veall N, Purkiss P (1983) Sequential studies of oxalate dynamics in primary hyperoxaluria. Clin Sci 65: 627–633

    PubMed  CAS  Google Scholar 

  • Watts RWE, Veall N, Purkiss P (1984) Oxalate dynamics and removal rates during haemodialysis and peritoneal dialysis in patients with primary hyperoxaluria and severe renal failure. Clin Sci 66: 591–597

    PubMed  CAS  Google Scholar 

  • Watts RWE, Veall N, Purkiss P, Mansell MA, Haywood EF (1985a) THe effect of pyridoxine on oxalate dynamics in three cases of primary hyperoxaluria (with glycollic aciduria). Clin Sci 69: 87–90

    PubMed  CAS  Google Scholar 

  • Watts RWE, Calne RY, Williams R et al. (1985b) Primary hyperoxaluria (type I): attempted treatment by combined hepatic and renal transplantation. Q J Med 57: 697–703

    PubMed  CAS  Google Scholar 

  • Watts RWE, Morgan SH, Purkiss P, Mansell MA, Baker LRI, Brown CB (1987a) Timing of renal transplantation in the management of pyridoxine resistant type I primary hyperoxaluria. Transplantation (in press)

    Google Scholar 

  • Watts RWE, Calne RY, Rolles K et al. (1987b) Successful treatment of primary hyperoxaluria type I by combined hepatic and renal transplantation. Lancet II: 474–475

    Article  Google Scholar 

  • Whelchel JD, Alison DV, Luke RG, Curtis J, Dietheim AC (1983) Successful renal transplantation in hyperoxaluria. A report of two cases. Transplantation 35: 161–164

    Article  PubMed  CAS  Google Scholar 

  • Williams HE, Smith LH (1983) Primary hyperoxaluria. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. 5th ed. McGraw-Hill, New York, pp 204–208

    Google Scholar 

  • Wilson RE (1975) A report from the ACS/NIH renal transplant registry. Renal transplantation in congenital and metabolic disease. JAMA 232: 148–153

    Article  Google Scholar 

  • Yendt ER, Cohanim M (1985) Response to a physiological dose of pyridoxine in type I primary hyperoxaluria. New Engl J Med 312: 953–957

    Article  PubMed  CAS  Google Scholar 

  • Zarembski PM, Rosen SM, Hodgkinson A (1969) Dialysis in the treatment of primary hyperoxaluria. Br J Urol 41: 530–533

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. A. Mansell
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  2. R. W. E. Watts
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Editor information

Editors and Affiliations

  1. St. Peter’s Hospitals, 24, Endell Street, WC2H 9AE, London, UK

    G. Alan Rose MA, MD, FRCP, FRCPath, FRSC (Consultant Chemical Pathologist) (Consultant Chemical Pathologist)

  2. Institute of Urology, London, St. Paul’s Hospital, 24, Endell Street, WC2H 9AE, London, UK

    G. Alan Rose MA, MD, FRCP, FRCPath, FRSC (Consultant Chemical Pathologist) (Consultant Chemical Pathologist)

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© 1988 Springer-Verlag Berlin Heidelberg

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Mansell, M.A., Watts, R.W.E. (1988). Renal Failure and Transplantation in Primary Hyperoxaluria. In: Rose, G.A. (eds) Oxalate Metabolism in Relation to Urinary Stone. The Bloomsbury Series in Clinical Science. Springer, London. https://doi.org/10.1007/978-1-4471-1626-4_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1626-4_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1628-8

  • Online ISBN: 978-1-4471-1626-4

  • eBook Packages: Springer Book Archive

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