Measurement of Human Normal Tissue and Tumour Responses
The scarcity of quantitative measures of normal tissue damage and tumour response in patients undergoing radiotherapy is an obstacle to the clinical evaluation of new treatment strategies. Retrospective studies of complications in critical normal tissues taught important lessons in the past concerning the potential dangers of hypofractionation (Singh 1978). However, it is unethical to use serious complications as planned end-points in prospective studies. One aim of this paper is to review the desirable characteristics of clinical end-points required to compare alternative treatments employing radiotherapy, with emphasis on simple scales applied by clinicians or even the patients themselves.
KeywordsToxicity Depression Lymphoma Serotonin Shrinkage
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