Abstract
The hypothesis that the relative radiation resistance of hypoxic tumour cells present in some human tumours can adversely affect the probability of local control in some clinical situations, remains a major research topic. There is some clinical evidence, mainly from studies using hyperbaric oxygen, that hypoxic cell resistance is a factor in the local control of some tumours. However, it is widely believed that tumour hypoxia is probably only important in some tumours; in others, reoxygenation occurring between fractions many effectively remove hypoxic cells during treatment. It is against the background of this heterogeneity with respect to the importance of hypoxia that attempts to demonstrate clinical radiation sensitization have been carried out. In retrospect, therefore, it is perhaps not surprising that the results of clinical trials with misonidazole have been generally disappointing. An urgent need is to develop methods of identifying those human tumours where hypoxic cell radioresistance is a problem. When such techniques become available the clinical efficacy of any new and improved sensitizer should be much more easily demonstrable.
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Adams, G., Stratford, I.J. (1988). Radiation Sensitizers and Related Compounds: New Approaches to Modification of Radiation Response. In: Bleehen, N.M. (eds) Radiobiology in Radiotherapy. Springer, London. https://doi.org/10.1007/978-1-4471-1603-5_14
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DOI: https://doi.org/10.1007/978-1-4471-1603-5_14
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