Skip to main content
SpringerLink
Log in

Clinical Aspects of Particle Therapy

  • Conference paper
Radiobiology in Radiotherapy

Abstract

Failure to control local disease is still a major cause of death in a large number of common cancers (Table 13.1). In addition to contributing to mortality itself uncontrolled local disease is often the cause of considerable distress to the patient and thus results in poor quality of life. There is therefore still a great need to improve tumour control at the primary site.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Battermann JJ, Mijnheer BJ (1986) The Amsterdam fast neutron therapy project: a final report. Int J Radiat Oncol Biol Phys 12: 2093–2099

    Article  PubMed  CAS  Google Scholar 

  • Bewley DK (1987) European accelerator for radiotherapy with charged ions. Lancet 1: 318–319

    Article  PubMed  CAS  Google Scholar 

  • Blake PR, Catterall M, Errington RD (1985) Treatment of malignant melanoma by fast neutrons. Br J Surg 72: 517 - 519

    Article  PubMed  CAS  Google Scholar 

  • Castro JR, Chen GTY, Blakeley EA (1985) Current considerations in heavy charged-particle radiotherapy: a clinical research trial of the University of California Lawrence Berkely Laboratory, Northern California Oncology Group and Radiation Therapy Oncology Group. Radiat Res 104: 5263–5271

    Article  Google Scholar 

  • Catterall M (1982a) The assessment of the results of neutron therapy. Int J Radiat Oncol Biol Phys 8: 1573–1780

    Article  PubMed  CAS  Google Scholar 

  • Catterall M (1982b) Results of neutron therapy: differences, correlations and improvements. Int J Radiat Oncol Biol Phys 8: 2141–2144

    Article  PubMed  CAS  Google Scholar 

  • Catterall M, Bewley DK (1979) Fast neutrons in the treatment of cancer. Academic Press, London Catterall M, Errington RD (1987) The implications of improved treatment of malignant salivary gland tumours by fast neutron radiotherapy. Int J Radiat Oncol Biol Phys 13: 1313–1318

    Google Scholar 

  • Catterall M, Errington RD, Bewley DK (1987) A comparison of clinical and laboratory data on neutron therapy for locally advanced tumours. Int J Radiat Oncol Biol Phys (in press)

    Google Scholar 

  • Cohen L, Hendrickson FR, Kurup PD et al. (1985) Clinical evaluation of neutron beam therapy. Current results and prospects, 1983. Cancer 55: 10–17

    Article  PubMed  CAS  Google Scholar 

  • Duncan W, Arnott SJ, Jack WJL et al. (1985). A report of a randomized trial of d() + Be neutrons compared with megavoltage X-ray therapy of bladder cancer. Int J Radiat Oncol Biol Phys 11: 2043 - 2049

    Article  PubMed  CAS  Google Scholar 

  • Duncan W, Williams JR, Kerr GR et al. (1986) An analysis of the radiation related morbidity observed in a randomised trial of neutron therapy for bladder cancer. Int J Radiat Oncol Biol Phys 12: 2085–2092

    Article  PubMed  CAS  Google Scholar 

  • Errington RD (1986) Advanced carcinoma of the paranasal sinuses treated with 7.5 MeV fast neutrons. Bull Cancer (Paris) 73: 569–576

    CAS  Google Scholar 

  • Errington RD, Catterall M (1986) Re-irradiation of advanced tumours of the head and neck with fast neutrons. Int J Radiat Oncol Biol Phys 12: 191–195

    PubMed  CAS  Google Scholar 

  • Field SB, Fowler JF (1984) The biological basis for neutron therapy. J Eur Radiother 5: 170–175

    Google Scholar 

  • Goitein M, Miller T (1983) Planning proton therapy of the eye. Med Phys 10: 275–283

    Article  PubMed  CAS  Google Scholar 

  • Goitein M, Gentry R, Koehler AM (1983) Energy proton accelerator necessary for treatment of choroidal melanomas. Int J Radiat Oncol Biol Phys 9: 259–260

    PubMed  CAS  Google Scholar 

  • Goitein M, Munzenrider J (1984) Proton therapy: good news and big challenges. Int J Radiat Oncol Biol Phys 10: 319–320

    Article  PubMed  CAS  Google Scholar 

  • Greiner RH, Van Essen CF, Blattmann HJ et al. (1986) Pion therapy at Swiss Insitute for Nuclear Research (SIN). Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 98

    Google Scholar 

  • Griffin TW, Davis, R, Laramore GE et al. (1983) Fast neutron irradiation of metastatic cervical adenopathy. The results of a randomized RTOG study. Int J Radiat Oncol Biol Phys 9: 1267–1270 Griffin

    Google Scholar 

  • TW, Davies R, Hendrickson FR et al. (1984) Fast neutron radiation therapy for unresectable squamous cell carcinoma of the head and neck: the results of a randomised RTOG study. Int J Radiat Oncol Biol Phys 10: 2217–2222

    Article  PubMed  CAS  Google Scholar 

  • Griffin TW, Pajak T, Laramore GE, Davis L (1986) Analysis of neutron radiotherapy treatment complications. Bull Cancer (Paris) 73: 582–586

    CAS  Google Scholar 

  • Hall EJ (1981) New modalities in cancer treatment: heavy charged particles. Br J Radiol 54: 773–781

    Article  PubMed  CAS  Google Scholar 

  • Hornsey S (1978) The relationship between total dose, number of fractions and fraction size in the response of malignant melanoma in patients. Br J Radiol 51: 905–909

    Article  PubMed  CAS  Google Scholar 

  • Laramore GE, Krall JM, Thomas FT et al. (1985) Fast neutron radiotherapy for locally advanced prostate cancer: results of an RTOG randomized study. Int J Radiat Oncol Biol Phys 11: 1621–1667

    Article  PubMed  CAS  Google Scholar 

  • Maor MH, Gillespie B, Peters LJ et al. (1986) Neutron therapy in cervical cancer: results of a Phase III RTOG study. Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 99–100

    Google Scholar 

  • McNally NJ, Wilson GD (1986) Cell kinetics of normal and perturbed populations measured by incorporation of bromodeoxyuridine and flow cytometry. Br J Radiol 59: 1015–1022

    Article  PubMed  CAS  Google Scholar 

  • Medical Research Council Neutron Therapy Working Group (1986) A comparative review of the Hammersmith (1971–75) and Edinburgh (1977–82) neutron therapy trials of certain cancers of the oral cavity, oropharynx, larynx and hypopharynx. Br J Radiol 59: 429–440

    Google Scholar 

  • Munzenrider JE, Austin-Seymour M, Blitzer PJ et al. (1985) Proton therapy at Harvard. Strahlentherapie 161: 756–763

    PubMed  CAS  Google Scholar 

  • Overgaard M, Overgaard J, Sell A (1984) Dose response for radiotherapy of recurrent, residual and primarily inoperable colorectal cancer. Radiother Oncol 1: 217–225

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J, Van der Maase J, Overgaard M (1985) A randomized study comparing two high-dose per fraction radiation schedules in recurrent or metastatic malignant melanomas. Int J Radiat Oncol Biol Phys 11: 1837–1839

    Article  PubMed  CAS  Google Scholar 

  • Peters LJ, Maor MH, Laramore GE et al. (1985) Review of clinical results of fast neutron therapy in the USA. Strahlentherapie 161: 731–738

    PubMed  CAS  Google Scholar 

  • Peters LJ, Maor MH, Laramore GE, Griffin TW, Hendrickson FR (1986) Review of clinical results of fast neutron therapy in the USA. In: Maruyama Y, Beach LJ, Feola JM (eds) Californium-252 brachytherapy and fast neutron beam therapy. Nuclear science applications. Harwood Academic Publishers, London, pp 243–260

    Google Scholar 

  • Pickering DG, Stewart JS, Rampling R, Errington RD, Stamp G, Chia Y (1987) Fast neutron therapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys 13: 1489–pl495

    Google Scholar 

  • Schmitt G, Furst G, Bamberg M (1986) The value of neutron and neutron-boost irradiation for the local control of advanced soft tissue sarcomas. Bull Cancer (Paris) 73: 577–581

    CAS  Google Scholar 

  • Seydel Gunter H (1984) Radiation sensitizers. In: Gilbert Harvey A (ed) Modern radiation oncology. Classic literature and current management, vol 2. Harper and Row, Philadelphia, pp 664–686

    Google Scholar 

  • Stone RS (1948) Janeway memorial lecture. Neutron therapy and specific ionization. Am J Roentgenol 59: 771–785

    CAS  Google Scholar 

  • Stone RS, Larkin JC (1942) The treatment of cancer with fast neutrons. Radiobiology 39: 608–620

    Google Scholar 

  • Suit HD, Goiten M (1980) Rationale for use of charged-particle and fast-neutron beams in radiation therapy. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven Press, New York, pp 547–565

    Google Scholar 

  • Thames HD, Peters LJ, Withers HR, Fletcher GH (1983) Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys 9: 127–138

    PubMed  Google Scholar 

  • Vikram B, Strong EW, Shah JP, Spiro RH (1984) Radiation therapy in adenoid cystic carcinoma. Int J Radiat Oncol Biol Phys 10: 221–223

    Article  PubMed  CAS  Google Scholar 

  • Von Essen CF, Bagshaw MM, Bush SE, Smith AR, Kligerman MM (1986) Long-term results of pion therapy at Los Alamos. Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 97

    Google Scholar 

  • Wambersie A, Batterman JJ (1985) Review and evaluation of clinical results in the EORIC Heavy-Particle Therapy Group. Strahlentherapie 161: 746–755

    PubMed  CAS  Google Scholar 

  • Wambersie A, Bewley DK, Lalanne CM (1986) Prospects for the application of fast neutrons in cancer therapy. Radiobiological bases and survey of the clinical data. Bull Cancer (Paris) 73: 546–561

    CAS  Google Scholar 

Download references

Authors
  1. H. M. Warenius
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. D. Errington
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Cambridge School of Clinical Medicine, Department of Clinical Oncology and Radiotherapeutics, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, UK

    Norman M. Bleehen FRCP, FRCR, Honorary FACR (Cancer Research Campaign Professor of Clinical Oncology, Honorary Director MRC Clinical Oncology and Radiotherapeutics Unit) (Cancer Research Campaign Professor of Clinical Oncology, Honorary Director MRC Clinical Oncology and Radiotherapeutics Unit)

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Warenius, H.M., Errington, R.D. (1988). Clinical Aspects of Particle Therapy. In: Bleehen, N.M. (eds) Radiobiology in Radiotherapy. Springer, London. https://doi.org/10.1007/978-1-4471-1603-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1603-5_13

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1605-9

  • Online ISBN: 978-1-4471-1603-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation