Clinical Aspects of Particle Therapy

  • H. M. Warenius
  • R. D. Errington
Conference paper

Abstract

Failure to control local disease is still a major cause of death in a large number of common cancers (Table 13.1). In addition to contributing to mortality itself uncontrolled local disease is often the cause of considerable distress to the patient and thus results in poor quality of life. There is therefore still a great need to improve tumour control at the primary site.

Keywords

Toxicity Europe Lymphoma Attenuation Argon 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Battermann JJ, Mijnheer BJ (1986) The Amsterdam fast neutron therapy project: a final report. Int J Radiat Oncol Biol Phys 12: 2093–2099PubMedCrossRefGoogle Scholar
  2. Bewley DK (1987) European accelerator for radiotherapy with charged ions. Lancet 1: 318–319PubMedCrossRefGoogle Scholar
  3. Blake PR, Catterall M, Errington RD (1985) Treatment of malignant melanoma by fast neutrons. Br J Surg 72: 517 - 519PubMedCrossRefGoogle Scholar
  4. Castro JR, Chen GTY, Blakeley EA (1985) Current considerations in heavy charged-particle radiotherapy: a clinical research trial of the University of California Lawrence Berkely Laboratory, Northern California Oncology Group and Radiation Therapy Oncology Group. Radiat Res 104: 5263–5271CrossRefGoogle Scholar
  5. Catterall M (1982a) The assessment of the results of neutron therapy. Int J Radiat Oncol Biol Phys 8: 1573–1780PubMedCrossRefGoogle Scholar
  6. Catterall M (1982b) Results of neutron therapy: differences, correlations and improvements. Int J Radiat Oncol Biol Phys 8: 2141–2144PubMedCrossRefGoogle Scholar
  7. Catterall M, Bewley DK (1979) Fast neutrons in the treatment of cancer. Academic Press, London Catterall M, Errington RD (1987) The implications of improved treatment of malignant salivary gland tumours by fast neutron radiotherapy. Int J Radiat Oncol Biol Phys 13: 1313–1318Google Scholar
  8. Catterall M, Errington RD, Bewley DK (1987) A comparison of clinical and laboratory data on neutron therapy for locally advanced tumours. Int J Radiat Oncol Biol Phys (in press)Google Scholar
  9. Cohen L, Hendrickson FR, Kurup PD et al. (1985) Clinical evaluation of neutron beam therapy. Current results and prospects, 1983. Cancer 55: 10–17PubMedCrossRefGoogle Scholar
  10. Duncan W, Arnott SJ, Jack WJL et al. (1985). A report of a randomized trial of d() + Be neutrons compared with megavoltage X-ray therapy of bladder cancer. Int J Radiat Oncol Biol Phys 11: 2043 - 2049PubMedCrossRefGoogle Scholar
  11. Duncan W, Williams JR, Kerr GR et al. (1986) An analysis of the radiation related morbidity observed in a randomised trial of neutron therapy for bladder cancer. Int J Radiat Oncol Biol Phys 12: 2085–2092PubMedCrossRefGoogle Scholar
  12. Errington RD (1986) Advanced carcinoma of the paranasal sinuses treated with 7.5 MeV fast neutrons. Bull Cancer (Paris) 73: 569–576Google Scholar
  13. Errington RD, Catterall M (1986) Re-irradiation of advanced tumours of the head and neck with fast neutrons. Int J Radiat Oncol Biol Phys 12: 191–195PubMedGoogle Scholar
  14. Field SB, Fowler JF (1984) The biological basis for neutron therapy. J Eur Radiother 5: 170–175Google Scholar
  15. Goitein M, Miller T (1983) Planning proton therapy of the eye. Med Phys 10: 275–283PubMedCrossRefGoogle Scholar
  16. Goitein M, Gentry R, Koehler AM (1983) Energy proton accelerator necessary for treatment of choroidal melanomas. Int J Radiat Oncol Biol Phys 9: 259–260PubMedGoogle Scholar
  17. Goitein M, Munzenrider J (1984) Proton therapy: good news and big challenges. Int J Radiat Oncol Biol Phys 10: 319–320PubMedCrossRefGoogle Scholar
  18. Greiner RH, Van Essen CF, Blattmann HJ et al. (1986) Pion therapy at Swiss Insitute for Nuclear Research (SIN). Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 98Google Scholar
  19. Griffin TW, Davis, R, Laramore GE et al. (1983) Fast neutron irradiation of metastatic cervical adenopathy. The results of a randomized RTOG study. Int J Radiat Oncol Biol Phys 9: 1267–1270 GriffinGoogle Scholar
  20. TW, Davies R, Hendrickson FR et al. (1984) Fast neutron radiation therapy for unresectable squamous cell carcinoma of the head and neck: the results of a randomised RTOG study. Int J Radiat Oncol Biol Phys 10: 2217–2222PubMedCrossRefGoogle Scholar
  21. Griffin TW, Pajak T, Laramore GE, Davis L (1986) Analysis of neutron radiotherapy treatment complications. Bull Cancer (Paris) 73: 582–586Google Scholar
  22. Hall EJ (1981) New modalities in cancer treatment: heavy charged particles. Br J Radiol 54: 773–781PubMedCrossRefGoogle Scholar
  23. Hornsey S (1978) The relationship between total dose, number of fractions and fraction size in the response of malignant melanoma in patients. Br J Radiol 51: 905–909PubMedCrossRefGoogle Scholar
  24. Laramore GE, Krall JM, Thomas FT et al. (1985) Fast neutron radiotherapy for locally advanced prostate cancer: results of an RTOG randomized study. Int J Radiat Oncol Biol Phys 11: 1621–1667PubMedCrossRefGoogle Scholar
  25. Maor MH, Gillespie B, Peters LJ et al. (1986) Neutron therapy in cervical cancer: results of a Phase III RTOG study. Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 99–100Google Scholar
  26. McNally NJ, Wilson GD (1986) Cell kinetics of normal and perturbed populations measured by incorporation of bromodeoxyuridine and flow cytometry. Br J Radiol 59: 1015–1022PubMedCrossRefGoogle Scholar
  27. Medical Research Council Neutron Therapy Working Group (1986) A comparative review of the Hammersmith (1971–75) and Edinburgh (1977–82) neutron therapy trials of certain cancers of the oral cavity, oropharynx, larynx and hypopharynx. Br J Radiol 59: 429–440Google Scholar
  28. Munzenrider JE, Austin-Seymour M, Blitzer PJ et al. (1985) Proton therapy at Harvard. Strahlentherapie 161: 756–763PubMedGoogle Scholar
  29. Overgaard M, Overgaard J, Sell A (1984) Dose response for radiotherapy of recurrent, residual and primarily inoperable colorectal cancer. Radiother Oncol 1: 217–225PubMedCrossRefGoogle Scholar
  30. Overgaard J, Van der Maase J, Overgaard M (1985) A randomized study comparing two high-dose per fraction radiation schedules in recurrent or metastatic malignant melanomas. Int J Radiat Oncol Biol Phys 11: 1837–1839PubMedCrossRefGoogle Scholar
  31. Peters LJ, Maor MH, Laramore GE et al. (1985) Review of clinical results of fast neutron therapy in the USA. Strahlentherapie 161: 731–738PubMedGoogle Scholar
  32. Peters LJ, Maor MH, Laramore GE, Griffin TW, Hendrickson FR (1986) Review of clinical results of fast neutron therapy in the USA. In: Maruyama Y, Beach LJ, Feola JM (eds) Californium-252 brachytherapy and fast neutron beam therapy. Nuclear science applications. Harwood Academic Publishers, London, pp 243–260Google Scholar
  33. Pickering DG, Stewart JS, Rampling R, Errington RD, Stamp G, Chia Y (1987) Fast neutron therapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys 13: 1489–pl495Google Scholar
  34. Schmitt G, Furst G, Bamberg M (1986) The value of neutron and neutron-boost irradiation for the local control of advanced soft tissue sarcomas. Bull Cancer (Paris) 73: 577–581Google Scholar
  35. Seydel Gunter H (1984) Radiation sensitizers. In: Gilbert Harvey A (ed) Modern radiation oncology. Classic literature and current management, vol 2. Harper and Row, Philadelphia, pp 664–686Google Scholar
  36. Stone RS (1948) Janeway memorial lecture. Neutron therapy and specific ionization. Am J Roentgenol 59: 771–785Google Scholar
  37. Stone RS, Larkin JC (1942) The treatment of cancer with fast neutrons. Radiobiology 39: 608–620Google Scholar
  38. Suit HD, Goiten M (1980) Rationale for use of charged-particle and fast-neutron beams in radiation therapy. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven Press, New York, pp 547–565Google Scholar
  39. Thames HD, Peters LJ, Withers HR, Fletcher GH (1983) Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys 9: 127–138PubMedGoogle Scholar
  40. Vikram B, Strong EW, Shah JP, Spiro RH (1984) Radiation therapy in adenoid cystic carcinoma. Int J Radiat Oncol Biol Phys 10: 221–223PubMedCrossRefGoogle Scholar
  41. Von Essen CF, Bagshaw MM, Bush SE, Smith AR, Kligerman MM (1986) Long-term results of pion therapy at Los Alamos. Int J Radiat Oncol Biol Phys 12 [Suppl 1. Proceedings of the American Society for Therapeutic Radiology and Oncology 28th annual meeting]: 97Google Scholar
  42. Wambersie A, Batterman JJ (1985) Review and evaluation of clinical results in the EORIC Heavy-Particle Therapy Group. Strahlentherapie 161: 746–755PubMedGoogle Scholar
  43. Wambersie A, Bewley DK, Lalanne CM (1986) Prospects for the application of fast neutrons in cancer therapy. Radiobiological bases and survey of the clinical data. Bull Cancer (Paris) 73: 546–561Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. M. Warenius
  • R. D. Errington

There are no affiliations available

Personalised recommendations