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Diagnosis of Liver Metastasis

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Abstract

Focal liver disease may be detected incidentally during cross-sectional imaging studies, at the time of cancer screening or follow-up and during laparotomy. Where surgery is being undertaken for colorectal cancer, for example, 26% of patients may be expected to have liver metastases and while a metastasis is the most common liver tumour detected and the majority arise from a colorectal primary cancer, some of the lesions found will represent benign disease of no clinical significance. A number of benign processes, such as haemangiomas and cysts, can mimic metastatic disease closely and in order that the most appropriate management is applied, it is clearly of paramount importance that an accurate distinction is made between significant and insignificant disease. Accurate characterization of a focal liver lesion, e.g. a simple cyst, may be possible using conventional ultrasound alone while other more complex pathologies may require multiple imaging studies and biopsy before a confident diagnosis can be made.

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References

  1. Machi J, Isomoto H, Kurhiji T et al. Accuracy of intraoperative ultrasound in diagnosing liver metastases from colorectal cancer: evaluation with post-operative follow-up results. World J Surg 1991; 15:551–557.

    Article  PubMed  CAS  Google Scholar 

  2. Takayasu K, Moriyama N, Muramatsu Y et al. The diagnosis of small hepatocellular carcinomas: Efficacy of various imaging procedures in 100 patients. AJR 1990; 155:49–54.

    PubMed  CAS  Google Scholar 

  3. Leen E, Angerson WG, Wotherspoon H, Moule B, Cooke TG, McCardle CS Comparison of DPI and IOUS in diagnosing occult colorectal liver metastases. Radiology 1995; 195:113–116.

    Google Scholar 

  4. Soyer P, Levesque M, Elias D, Zeitoun G, Roche A. Preoperative assessment of resectability of hepatic metastases from colonic carcinoma: CT portography vs sonography and dynamic CT. AJR 1992; 159:741–744.

    PubMed  CAS  Google Scholar 

  5. Soyer P, Levesque M, Elias D et al. Detection of liver metastases from colorectal cancer: comparison of intraoperative US and CT during arterial portography. Radiology 1992; 183:541–544.

    Google Scholar 

  6. Machi J, Isomoto H, Yamashita Y et al. Intraoperative ultrasonography in the screening for liver metastases from colorectal cancer: comparative accuracy with traditional procedures. Surgery 1987; 101(6):678–684.

    PubMed  CAS  Google Scholar 

  7. Ferrucci JT. Liver tumour imaging: current concepts. AJR 1990; 150:473–484.

    Google Scholar 

  8. Wernecke K, Vassallo P, Bick U, Diederich S, Peters P. The distinction between benign and malignant liver tumours on sonography: value of a hypoechoic halo. AJR 1992; 159:1005–1009.

    Google Scholar 

  9. Kudo M, Tomita S, Tochio H et al. Sonographic angiography: value in differential diagnosis of hepatic tumours. AJR 1992; 158:65–74.

    Google Scholar 

  10. Maresca G, Barbaro B, Summaria V et al. Colour Doppler ultrasonography in the differential diagnosis of focal hepatic lesions. The SHU 508A experience. Radiol Med 1994; 87(Suppl 1 al n 5):41–49.

    Google Scholar 

  11. Freeny PC, Marks WM Hepatic haemangioma: dynamic bolus CT. AJR 1986; 147:711–719.

    PubMed  CAS  Google Scholar 

  12. Charnley RM, Morris DL, Dennison AR et al. Detection of colorectal liver metastases using intraoperative ultrasonography. Br J Surg 1991; 78:45–48.

    Article  PubMed  CAS  Google Scholar 

  13. Kudo M, Tomita S, Tochio H et al. Small hepatocellular carcinoma: diagnosis with US angiography with intraarterial CO2 microbubbles. Radiology 1992; 182:155–160.

    PubMed  CAS  Google Scholar 

  14. Garbagnati F, Milella M, Spreafico C et al. US contrast enhancement with intraarterial CO2 injection in staging hepatocellular carcinomas. Radiol Med 1994; 87:(Suppl. 1):65-

    Google Scholar 

  15. Kubo S, Kinoshita H, Hirohashi T et al. Preoperative localization of hepatomas by sonography with microbubbles of carbon dioxide. AJR 1994; 1405–6.

    Google Scholar 

  16. El Mouaaouy A, Becker HD, Schlief R et al. Rat liver model for testing intraoperative echo contrast sonography. Surg Endosc 1990; 4:114–117.

    Article  PubMed  Google Scholar 

  17. Braunschweig R, Stern W, Dabidian A et al. Contrast enhanced colour Doppler studies of liver vessels. Abstract of Investigators meeting in Berlin. Echocardiography 1993; November issue.

    Google Scholar 

  18. Olliff S, Olliff J. Assessment of SHU 508A for enhancement of Doppler signals in liver and kidney vessels and renal tumours. Abstract of Investigators meeting in Berlin. Echocardiography 1993; November issue.

    Google Scholar 

  19. Leen E, Angerson WJ, Warren H et al. Improved colour Doppler flow imaging of colorectal hepatic metastases using galactose microparticles: a preliminary report. Br J Surg 1994; 220(5):663–667.

    CAS  Google Scholar 

  20. Angeli E, Carpanelli R, Crespi G et al. Efficacy of SHU 508 A in colour Doppler ultrasonography of hepatocellular carcinoma vascularisation. Radiol Med 1994; 87(Suppl. 1 al n.5):24–31.

    PubMed  CAS  Google Scholar 

  21. Carter R, Anderson JH, Cooke TG et al. Is the change in the hepatic perfusion index in the presence of hepatic metastases due to a humoural agent? Br J Cancer 1992; 65:58.

    Article  Google Scholar 

  22. Warren HW, Angerson WJ, Leen E et al. Haemodynamic changes associated with colorectal liver metastases: evidence of a humoural mediator. Br J Surg 1993; 80:1461.

    Google Scholar 

  23. Leen E, Angerson WJ, Wotherspoon H, Moule B, Cooke TG, McCardle CS 1993; Comparison of DPI and IOUS in diagnosing occult colorectal liver metastases. Ann Surg 1994; 220(5):663–667.

    Article  PubMed  CAS  Google Scholar 

  24. Leen E, Angerson WJ, Wotherspoon H, Moule B, Cooke TG, McCardle CS Comparison of laparotomy, CT, US and DPI in the detection of colorectal metastases. Radiology 1995; 195:113–116.

    PubMed  CAS  Google Scholar 

  25. Leen E, Angerson WJ, Moule B, Cooke TG, McCardle CS Prognostic power of DPI in patients following curative resection for colorectal cancer: correlation with outcome at two years. Ann Surg 1996; 223(2):199–203.

    Article  PubMed  CAS  Google Scholar 

  26. P A Garcia, VM, Bonaldi, Bret PM et al. Effect of rate of contrast medium injection on hepatic enhancement at CT. Radiology 1996; 199:185–189.

    PubMed  CAS  Google Scholar 

  27. Small WC, Nelson RC, Bernardino ME, Brummer LT Contrast-enhanced spiral CT of the liver: effect of different amounts and injection rates of contrast material on early contrast enhancement. AJR 1994; 163:87–92.

    PubMed  CAS  Google Scholar 

  28. Dodd GD, Baron RL. Investigation of contrast enhancement in CT of the liver; the need for improved methods (commentary) AJR 1993; 160:643–646.

    PubMed  Google Scholar 

  29. Silverman PM, Roberts S, Tefft MC et al. Helical CT of the liver; clinical application of an automated computer technique, Smartprep, for obtaining images with optimal contrast enhancement. AJR 1995; 165:73–78.

    PubMed  CAS  Google Scholar 

  30. Soyer P, Bluemke DA, Hruban RH, Sitzmann JV, Fishman EK. Primary malignant neoplasms from colorectal cancer: detection and false positive findings with helical CT during arterial portography. Radiology 1994; 192:389–392.

    PubMed  CAS  Google Scholar 

  31. Seneterre E, Taourel P, Bouvier Y et al. Detection of hepatic metastases: ferumoxide-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography Radiology 1996; 200:785–792

    PubMed  CAS  Google Scholar 

  32. Soyer P, J-p Laissy, A Sibert et al. Focal hepatic masses: comparison of detection during arterial portography with MR imaging and CT. Radiology 1994; 737–740.

    Google Scholar 

  33. Sitzmann JV, Coleman JA, Pitt HA, Zerhouni E, Fishman E, Kaufman SL. Preoperative assessment of malignant tumours. Am J Surg 1990; 159:137–142.

    Article  PubMed  CAS  Google Scholar 

  34. Hagspiel KD, Neidl KFW, Eichenberger AC et al. Detection of liver metastases: comparison of SPIO enhanced and unenhanced MRI at 1.5T with dynamic CT, IOUS and percutaneous US. Radiology 1995; 196:471–478.

    PubMed  CAS  Google Scholar 

  35. Abdel-Nabi H, Levine G, Lamki L et al. Colorectal carcinoma metastases: Detection with IIIIn-labelled monoclonal antibody CCR086. Radiology 1990; 176:117–122.

    PubMed  CAS  Google Scholar 

  36. Abdel-Nabi H, Doerr RJ, Chan HW et al. IIIIn-labelled monoclonal antibody immunoscintigraphy in colorectal carcinoma: safety, sensitivity and preliminary clinical results. Radiology 1992; 185:179–186.

    PubMed  Google Scholar 

  37. Collier BD, Abdel-Nabi H, Doerr RJ et al. Immunoscintigraphy performed with IIIIn-labelled CYT-103 in the management of colorectal cancer: comparison with CT. Radiology 1992; 185:179–186.

    PubMed  CAS  Google Scholar 

  38. Doerr RJ, Abdel-Nabi H, Krag D et al. Radiolabeled antibody imaging in the management of colorectal cancer: results of a multicentre clinical study. Ann Surg 1991; 214(2):118–124.

    Article  PubMed  CAS  Google Scholar 

  39. Scott AM, Macalpinlac HA, Divgi CR et al. Clinical validation of SPECT and CT/MRI image registration in radiolabeled monoclonal antibody studies of colorectal carcinoma. J Nucl Med 1994; 35(12):1976–1984.

    PubMed  CAS  Google Scholar 

  40. Lamki LM, Patt YZ, Rosenblum MG et al. Metastatic colorectal cancer: Radioimmunoscintigraphy with a stabilised IIIInlabeled F (ab׳)2 fragment of an anti-CEA monoclonal antibody. Radiology 1990; 14:370–374.

    Google Scholar 

  41. Aftab F, Stoldt HS, Testori A et al. Radioimmunoguided surgery and colorectal cancer (Review) Eur J Surg Oncol 1996(Aug); 22(4): 381–388.

    Google Scholar 

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© 1998 Springer-Verlag London Limited

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Redhead, D.N., Leen, E. (1998). Diagnosis of Liver Metastasis. In: Garden, O.J., Geraghty, J.G., Nagorney, D.M., Audisio, R.A., Stoldt, H.S. (eds) Liver Metastases. Springer, London. https://doi.org/10.1007/978-1-4471-1506-9_5

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  • DOI: https://doi.org/10.1007/978-1-4471-1506-9_5

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1508-3

  • Online ISBN: 978-1-4471-1506-9

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